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2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase

This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.100

Reaction

S-adenosyl-L-methionine
+
protein C-terminal S-farnesyl-L-cysteine
=
S-adenosyl-L-homocysteine
 +
protein C-terminal S-farnesyl-L-cysteine methyl ester

Synonyms

EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + biotin-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + biotin-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C10-Diazirine)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C5-m-BP)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(Fr)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + biotin-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + farnesylated and Rce1-proteolyzed K-Ras protein
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine methyl ester
show the reaction diagram
-
relatively good substrate for the human Icmt enzyme
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-(E)-geranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-(E)-geranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-3,3-dimethylalkyl-L-cysteine
S-adenosyl-L-homocysteine + S-methyl N-acetyl-S-3,3-dimethylalkyl-L-cysteine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
?
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
no activity with + N-acetyl-S-geranylgeranyl-L-cysteinyl-S-geranylgeranyl-L-cysteine
-
?
S-adenosyl-L-methionine + N-acetyl-S-trans,trans-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-trans,trans-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-biotinyl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine peptide
S-adenosyl-L-homocysteine + biotin S-farnesyl-L-cysteine peptide methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + Ras2p
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + S-[(2E,6E)-farnesyl]-3-sulfanylpropanoic acid
S-adenosyl-L-homocysteine + methyl S-[(2E,6E)-farnesyl]-3-sulfanylpropanoate
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + S-[(2E,6E)-farnesyl]-sulfanylacetic acid
S-adenosyl-L-homocysteine + methyl S-[(2E,6E)-farnesyl]-sulfanylacetate
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosylmethionine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-(benzoylglycyl)-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-(benzoylglycyl)-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-D-cysteine
S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-D-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosylmethionine + N-acetyl-S-3,3-dimethylallyl-L-cysteine
S-adenosylhomocysteine + N-acetyl-S-3,3-dimethylallyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-isobutyryl-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-isobutyryl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-isovaleryl-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-isovaleryl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
S-adenosylmethionine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
additional information
?
-