Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase

This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.100

Reaction

S-adenosyl-L-methionine
+
protein C-terminal S-farnesyl-L-cysteine
=
S-adenosyl-L-homocysteine
+
protein C-terminal S-farnesyl-L-cysteine methyl ester

Synonyms

EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase

Reference

Reference on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Clarke, S.; Vogel, J.P.; Deschenes, R.J.; Stock, J.
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases [published erratum appears in Proc Natl Acad Sci U S A 1988 Oct;85(20):7556]
Proc. Natl. Acad. Sci. USA
85
4643-4647
1988
Rattus norvegicus
Manually annotated by BRENDA team
Stephenson, R.C.; Clarke, S.
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate
J. Biol. Chem.
265
16248-16254
1990
Rattus norvegicus
Manually annotated by BRENDA team
Hrycyna, C.A.; Sapperstein, S.K.; Clarke, S.; Michaelis, S.
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins
EMBO J.
10
1699-1709
1991
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hrycyna, C.A.; Clarke, S.
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae
Mol. Cell. Biol.
10
5071-5076
1990
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Volker, C.; Miller, R.A.; McCleary, W.R.; Rao, A.; Poenie, M.; Backer, J.M.; Stock, J.B.
Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction
J. Biol. Chem.
266
21515-21522
1991
Rattus norvegicus
Manually annotated by BRENDA team
Shi, Y.Q.; Rando, R.R.
Kinetic mechanism of isoprenylated protein methyltransferase
J. Biol. Chem.
267
9547-9551
1992
Bos taurus
Manually annotated by BRENDA team
Perez-Sala, D.; Gilbert, B.A.; Tan, E.W.; Rando, R.R.
Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates
Biochem. J.
284
835-840
1992
Bos taurus
Manually annotated by BRENDA team
Yoo, Y.; Watts, S.; Rechsteiner, M.
Ubiquitin-RAS peptide extensions as substrates for farnesyl-protein transferase and carboxymethyltransferase
Biochem. J.
285
55-60
1992
Oryctolagus cuniculus
Manually annotated by BRENDA team
Gingras, D.; Beliveau, R.
Cytosolic proteins of 21-23 kDa are methylated by kidney cortex membrane-associated C-terminal carboxyl methyltransferases
Biochim. Biophys. Acta
1204
149-156
1994
Rattus norvegicus
Manually annotated by BRENDA team
Boivin, D.; Potier, M.; Beliveau, R.
Functional size of C-terminal protein carboxyl methyltransferase from kidney basolateral plasma membranes
Biochim. Biophys. Acta
1207
114-119
1994
Saccharomyces cerevisiae, Rattus norvegicus
Manually annotated by BRENDA team
Park, S.H.; Lee, H.W.
Inhibition of C-terminal O-methyltransferase by a rat liver cytosolic peptide
Arch. Pharm. Res.
17
354-359
1994
Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Klein, Z.; Ben-Baruch, G.; Marciano, D.; Solomon, R.; Altaras, M.; Kloog, Y.
Characterization of the prenylated protein methyltransferase in human endometrial carcinoma
Biochim. Biophys. Acta
1226
330-336
1994
Homo sapiens
Manually annotated by BRENDA team
Pillinger, M.H.; Volker, C.; Stock, J.B.; Weissmann, G.; Philips, M.R.
Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase in human neutrophils
J. Biol. Chem.
269
1486-1492
1994
Homo sapiens
Manually annotated by BRENDA team
Giner, J.L.; Rando, R.R.
Novel methyltransferase activity modifying the carboxy terminal bis(geranylgeranyl)-Cys-Ala-Cys structure of small GTP-binding proteins
Biochemistry
33
15116-15123
1994
Bos taurus
Manually annotated by BRENDA team
Ma, Y.T.; Shi, Y.Q.; Lim, Y.H.; McGrail, S.H.; Ware, J.A.; Rando, R.R.
Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase
Biochemistry
33
5414-5420
1994
Homo sapiens
Manually annotated by BRENDA team
Park, K.S.; Choi, S.Y.; Park, G.H.; Kim, S.
Studies on mammalian brain protein farnesyl-cysteine carboxyl-methyltransferase
Korean J. Biochem.
26
47-57
1994
Bos taurus, Rattus norvegicus
-
Manually annotated by BRENDA team
Li, G.; Kowluru, A.; Metz, S.A.
Characterization of prenylcysteine methyltransferase in insulin-secreting cells
Biochem. J.
316
345-351
1996
Rattus norvegicus
-
Manually annotated by BRENDA team
Boivin, D.; Lin, W.; Beliveau, R.
Essential arginine residues in isoprenylcysteine protein carboxyl methyltransferase
Biochem. Cell Biol.
75
63-69
1997
Rattus norvegicus
Manually annotated by BRENDA team
Marciano, D.; Aharonson, Z.; Varsano, T.; Haklai, R.; Kloog, Y.
Novel inhibitors of the prenylated protein methyltransferase reveal distinctive structural requirements
Bioorg. Med. Chem. Lett.
7
1709-1714
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Crowell, D.N.; Sen, S.E.; Randall, S.K.
Prenylcysteine a-carboxyl methyltransferase in suspension-cultured tobacco cells
Plant Physiol.
118
115-123
1998
Nicotiana tabacum
Manually annotated by BRENDA team
Yoo, B.C.; Kang, M.S.; Kim, S.; Lee, Y.S.; Choi, S.Y.; Ryu, C.K.; Park, G.H.; Han, J.S.
Partial purification of protein farnesyl cysteine carboxyl methyltransferase from bovine brain
Exp. Mol. Med.
30
227-234
1998
Bos taurus
Manually annotated by BRENDA team
Hong, K.M.; Choi, Y.B.; Hong, J.H.; Chang, H.S.; Rhee, K.I.; Park, H.; Paik, M.K.
Cysteine carboxyl O-methylation of human placental 23 kDa protein
Exp. Mol. Med.
31
30-35
1999
Homo sapiens
Manually annotated by BRENDA team
Hasne, M.P.; Lawrence, F.
Characterization of prenylated protein methyltransferase in Leishmania
Biochem. J.
342
513-518
1999
Leishmania donovani
-
Manually annotated by BRENDA team
De Busser, H.M.; Van Dessel, G.A.F.; Lagrou, A.R.
Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells
Int. J. Biochem. Cell Biol.
32
1007-1016
2000
Bos taurus
Manually annotated by BRENDA team
Van Dessel, G.A.F.; De Busser, H.M.; Lagrou, A.R.
Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells
Int. J. Biochem. Cell Biol.
34
477-486
2002
Homo sapiens
Manually annotated by BRENDA team
Buckner, F.S.; Kateete, D.P.; Lubega, G.W.; Van Voorhis, W.C.; Yokoyama, K.
Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates
Biochem. J.
367
809-816
2002
Mus musculus, Trypanosoma brucei
Manually annotated by BRENDA team
Choy, E.; Philips, M.
Expression and activity of human prenylcysteine-directed carboxyl methyltransferase
Methods Enzymol.
325
101-114
2000
Homo sapiens
Manually annotated by BRENDA team
Jitkova, J.; Carrigan, C.N.; Poulter, C.D.; Krylov, S.N.
Monitoring the three enzymatic activities involved in posttranslational modifications of Ras proteins
Anal. Chim. Acta
521
1-7
2004
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Baron, R.A.; Casey, P.J.
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)
BMC Biochem.
5
19
2004
Homo sapiens
Manually annotated by BRENDA team
Lu, Q.; Harrington, E.O.; Hai, C.M.; Newton, J.; Garber, M.; Hirase, T.; Rounds, S.
Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation
Circ. Res.
94
306-315
2004
Bos taurus
Manually annotated by BRENDA team
Papaharalambus, C.; Sajjad, W.; Syed, A.; Zhang, C.; Bergo, M.O.; Alexander, R.W.; Ahmad, M.
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase
J. Biol. Chem.
280
18790-18796
2005
Homo sapiens
Manually annotated by BRENDA team
Anderson, J.L.; Frase, H.; Michaelis, S.; Hrycyna, C.A.
Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p
J. Biol. Chem.
280
7336-7345
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kramer, K.; Harrington, E.O.; Lu, Q.; Bellas, R.; Newton, J.; Sheahan, K.L.; Rounds, S.
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis
Mol. Biol. Cell
14
848-857
2003
Bos taurus
Manually annotated by BRENDA team
Febo-Ayala, W.; Morera-Felix, S.L.; Hrycyna, C.A.; Thompson, D.H.
Functional reconstitution of the integral membrane enzyme, isoprenylcysteine carboxyl methyltransferase, in synthetic bolalipid membrane vesicles
Biochemistry
45
14683-14694
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Baron, R.A.; Peterson, Y.K.; Otto, J.C.; Rudolph, J.; Casey, P.J.
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules
Biochemistry
46
554-560
2007
Spodoptera frugiperda
Manually annotated by BRENDA team
Donelson, J.L.; Hodges, H.B.; Macdougall, D.D.; Henriksen, B.S.; Hrycyna, C.A.; Gibbs, R.A.
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Bioorg. Med. Chem. Lett.
16
4420-4423
2006
Homo sapiens
Manually annotated by BRENDA team
Leow, J.L.; Baron, R.; Casey, P.J.; Go, M.L.
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Bioorg. Med. Chem. Lett.
17
1025-1032
2007
Homo sapiens
Manually annotated by BRENDA team
Anderson, J.L.; Henriksen, B.S.; Gibbs, R.A.; Hrycyna, C.A.
The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors
J. Biol. Chem.
280
29454-29461
2005
Homo sapiens, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Winter-Vann, A.M.; Baron, R.A.; Wong, W.; dela Cruz, J.; York, J.D.; Gooden, D.M.; Bergo, M.O.; Young, S.G.; Toone, E.J.; Casey, P.J.
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
Proc. Natl. Acad. Sci. USA
102
4336-4341
2005
Homo sapiens
Manually annotated by BRENDA team
Cushman, I.; Casey, P.J.
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration
J. Biol. Chem.
284
27964-27973
2009
Homo sapiens
Manually annotated by BRENDA team
Buchanan, M.S.; Carroll, A.R.; Fechner, G.A.; Boyle, A.; Simpson, M.; Addepalli, R.; Avery, V.M.; Hooper, J.N.; Cheung, T.; Chen, H.; Quinn, R.J.
Aplysamine 6, an alkaloidal inhibitor of isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.
J. Nat. Prod.
71
1066-1067
2008
Pseudoceratina sp., Pseudoceratina sp. 1247
Manually annotated by BRENDA team
Wright, L.P.; Court, H.; Mor, A.; Ahearn, I.M.; Casey, P.J.; Philips, M.R.
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe
Mol. Cell. Biol.
29
1826-1833
2009
Homo sapiens
Manually annotated by BRENDA team
Buchanan, M.S.; Carroll, A.R.; Fechner, G.A.; Boyle, A.; Simpson, M.; Addepalli, R.; Avery, V.M.; Forster, P.I.; Guymer, G.P.; Cheung, T.; Chen, H.; Quinn, R.J.
Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx
Phytochemistry
69
1886-1889
2008
Homo sapiens
Manually annotated by BRENDA team
Huizinga, D.H.; Omosegbon, O.; Omery, B.; Crowell, D.N.
Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis
Plant Cell
20
2714-2728
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q93W54)
Manually annotated by BRENDA team
Bergman, J.A.; Hahne, K.; Song, J.; Hrycyna, C.A.; Gibbs, R.A.
S-farnesyl-thiopropionic acid (FTPA) triazoles as potent inhibitors of isoprenylcysteine carboxyl methyltransferase
ACS Med. Chem. Lett.
3
15-19
2012
Homo sapiens
Manually annotated by BRENDA team
Bergman, J.A.; Hahne, K.; Hrycyna, C.A.; Gibbs, R.A.
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors
Bioorg. Med. Chem. Lett.
21
5616-5619
2011
Homo sapiens
Manually annotated by BRENDA team
Majmudar, J.D.; Hodges-Loaiza, H.B.; Hahne, K.; Donelson, J.L.; Song, J.; Shrestha, L.; Harrison, M.L.; Hrycyna, C.A.; Gibbs, R.A.
Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization
Bioorg. Med. Chem.
20
283-295
2012
Homo sapiens
Manually annotated by BRENDA team
Cushman, I.; Casey, P.J.
RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion
Cell Adh. Migr.
5
11-15
2011
Homo sapiens
Manually annotated by BRENDA team
Griggs, A.M.; Hahne, K.; Hrycyna, C.A.
Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p
J. Biol. Chem.
285
13380-13387
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Go, M.L.; Leow, J.L.; Gorla, S.K.; Schueller, A.P.; Wang, M.; Casey, P.J.
Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase
J. Med. Chem.
53
6838-6850
2010
Homo sapiens
Manually annotated by BRENDA team
Judd, W.R.; Slattum, P.M.; Hoang, K.C.; Bhoite, L.; Valppu, L.; Alberts, G.; Brown, B.; Roth, B.; Ostanin, K.; Huang, L.; Wettstein, D.; Richards, B.; Willardsen, J.A.
Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)
J. Med. Chem.
54
5031-5047
2011
Homo sapiens
Manually annotated by BRENDA team
Yang, J.; Kulkarni, K.; Manolaridis, I.; Zhang, Z.; Dodd, R.B.; Mas-Droux, C.; Barford, D.
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT
Mol. Cell
44
997-1004
2011
Methanosarcina acetivorans
Manually annotated by BRENDA team
Hahne, K.; Vervacke, J.S.; Shrestha, L.; Donelson, J.L.; Gibbs, R.A.; Distefano, M.D.; Hrycyna, C.A.
Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes
Biochem. Biophys. Res. Commun.
423
98-103
2012
Saccharomyces cerevisiae, Homo sapiens
Manually annotated by BRENDA team
Ramanujulu, P.M.; Yang, T.; Yap, S.Q.; Wong, F.C.; Casey, P.J.; Wang, M.; Go, M.L.
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt)
Eur. J. Med. Chem.
63
378-386
2013
Homo sapiens
Manually annotated by BRENDA team
Grams, D.; Lockey, R.; Kolliputi, N.
Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing?
Front. Aging Neurosci.
5
40
2013
Mus musculus
Manually annotated by BRENDA team
Diver, M.M.; Long, S.B.
Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites
J. Biol. Chem.
289
26007-26020
2014
Homo sapiens, Anopheles gambiae (Q7PXA7), Anopheles gambiae
Manually annotated by BRENDA team
Bhadoriya, K.; Sharma, M.; Jain, S.
Pharmacophore modeling and atom-based 3D-QSAR studies on amino derivatives of indole as potent isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitors
J. Mol. Struct.
1081
466-476
2015
Homo sapiens
-
Manually annotated by BRENDA team
Vervacke, J.S.; Funk, A.L.; Wang, Y.C.; Strom, M.; Hrycyna, C.A.; Distefano, M.D.
Diazirine-containing photoactivatable isoprenoid: synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase
J. Org. Chem.
79
1971-1978
2014
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Teh, J.T.; Zhu, W.L.; Ilkayeva, O.R.; Li, Y.; Gooding, J.; Casey, P.J.; Summers, S.A.; Newgard, C.B.; Wang, M.
Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism
Oncogene
34
3296-3304
2015
Homo sapiens
Manually annotated by BRENDA team
Ibrahim, M.X.; Sayin, V.I.; Akula, M.K.; Liu, M.; Fong, L.G.; Young, S.G.; Bergo, M.O.
Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria
Science
340
1330-1333
2013
Mus musculus (Q9EQK7), Mus musculus
Manually annotated by BRENDA team
Liu, Q.; Chen, J.; Fu, B.; Dai, J.; Zhao, Y.; Lai, L.
Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation
Biochem. Biophys. Res. Commun.
501
556-562
2018
Homo sapiens (A0A024R4F6), Homo sapiens
Manually annotated by BRENDA team
Zhu, Y.; Hu, Q.; Li, H.
Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation
Biochem. Biophys. Res. Commun.
516
784-789
2019
Homo sapiens (A0A024R4F6)
Manually annotated by BRENDA team
Borini Etichetti, C.; Di Benedetto, C.; Rossi, C.; Baglioni, M.V.; Bicciato, S.; Del Sal, G.; Menacho-Marquez, M.; Girardini, J.
Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor
J. Biol. Chem.
294
5060-5073
2019
Homo sapiens
Manually annotated by BRENDA team
Butler, K.V.; Bohn, K.; Hrycyna, C.A.; Jin, J.
Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferase
MedChemComm
7
1016-1021
2016
Homo sapiens (O60725), Homo sapiens
Manually annotated by BRENDA team
Lau, H.Y.; Tang, J.; Casey, P.J.; Wang, M.
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms
Oncogene
36
3934-3942
2017
Homo sapiens (O60725), Homo sapiens
Manually annotated by BRENDA team
Do, M.T.; Chai, T.F.; Casey, P.J.; Wang, M.
Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin beta3 recycling, cell migration and cancer metastasis
Oncogene
36
5757-5767
2017
Homo sapiens (O60725)
Manually annotated by BRENDA team