2.1.1.1: nicotinamide N-methyltransferase
This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.1 - nicotinamide N-methyltransferase
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REACTION DIAGRAM
L-methionine + nicotinamide
L-homocysteine + 1-methylnicotinamide
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-
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?
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + ?
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-
-
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?
S-adenosyl-L-methionine + 2-methoxypyridine
S-adenosyl-L-homocysteine + 1-methyl-2-methoxypyridinium
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-
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?
S-adenosyl-L-methionine + 2-methylpyridine
S-adenosyl-L-homocysteine + 1,2-dimethylpyridinium
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-
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?
S-adenosyl-L-methionine + 3-acetylpyridine
S-adenosyl-L-homocysteine + ?
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-
-
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?
S-adenosyl-L-methionine + 3-acetylpyridine
S-adenosyl-L-homocysteine + N-methyl-3-acetylpyridinium
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-
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?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
S-adenosyl-L-methionine + 4-phenylpyridine
S-adenosyl-L-homocysteine + 1-methyl-4-phenylpyridine
poor substrate
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?
S-adenosyl-L-methionine + isoquinoline
S-adenosyl-L-homocysteine + N-methylisoquinoline
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-
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?
S-adenosyl-L-methionine + nicotinimidamide
S-adenosyl-L-homocysteine + N-methylnicotinimidamide
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-
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?
S-adenosyl-L-methionine + norharman + H+
S-adenosyl-L-homocysteine + 2-N-methylnorharman
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-
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?
S-adenosyl-L-methionine + quinoline 3-carboxamide
S-adenosyl-L-homocysteine + N-methylquinoline 3-carboxamide
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?
S-adenosyl-L-methionine + tetrahydroisoquinoline
S-adenosyl-L-homocysteine + N-methyltetrahydroisoquinoline
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?
S-adenosyl-L-methionine + thionicotinamide
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
1-methylnicotinamide + S-adenosyl-L-homocysteine
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?
nicotinamide + S-adenosyl-L-methionine
1-methylnicotinamide + S-adenosyl-L-homocysteine
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?
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
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?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
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assay for fluorometric determination of enzyme activity
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?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
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assay for fluorometric determination of enzyme activity
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?
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT as potential candidate for a tumor marker
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT gene polymorphism as potential marker for cardiovascular risk factors
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT potential as tumor marker
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
polymorphism in the nicotinamide N-methyltransferase (NNMT) gene as risk factor for complex congenital heart defects (CHDs)
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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L-methionine + nicotinamide
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?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
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?
S-adenosyl-L-homocysteine + N-methylquinoline
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?
S-adenosyl-L-methionine + quinoline
S-adenosyl-L-homocysteine + N-methylquinoline
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?
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
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?
S-adenosyl-L-methionine + thionicotinamide
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
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?
?
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NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds
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additional information
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development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
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additional information
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NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively
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additional information
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NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively
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additional information
?
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development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
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?
additional information
?
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development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
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?
additional information
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enzyme may function in detoxificating of numerous alkaloids
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?