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2.1.1.1: nicotinamide N-methyltransferase

This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
nicotinamide
 +
H+
=
S-adenosyl-L-homocysteine
 +
1-methylnicotinamide

Synonyms

ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.1 nicotinamide N-methyltransferase

IC50 Value

IC50 Value on EC 2.1.1.1 - nicotinamide N-methyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0069
1,3-dimethylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0075
1,4-dimethylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0046
1,5-dimethylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0018
1,8-dimethylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0087
1-ethyl-4-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0036
1-ethyl-6-fluoro-4-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0031
1-ethyl-8-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0099
1-methyl-3-(methylamino)quinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.023
1-methylnicotinamide
Homo sapiens
substrate quinoline, pH 8.6, 37°C
0.0063
2-amino-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.031
3-(6-amino-6-oxohexyl)benzamide
Homo sapiens
pH 8.6, 37°C
0.0029
3-amino-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.0063
3-amino-2-methylisoquinolin-2-ium
Homo sapiens
pH 8.6, 37°C
-
0.0012
3-amino-6-fluoro-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.099
4-methyl-N'-methylnicotinamide
Homo sapiens
pH 8.6, 37°C
0.0175
5'-([(3S)-3-amino-3-carboxypropyl][[3-(methoxycarbonyl)phenyl]methyl]amino)-5'-deoxyadenosine
Homo sapiens
pH 8.4, 37°C
0.0014
5'-deoxy-5'-[[(3S)-3,4-diamino-4-oxobutyl][(naphthalen-2-yl)methyl]amino]adenosine
Homo sapiens
pH 8.4, 37°C
0.0139
5'-deoxy-5'-[[(naphthalen-2-yl)methyl](propan-2-yl)amino]adenosine
Homo sapiens
pH 8.4, 37°C
0.000016
5'-[(3-amino-3-carboxypropyl)[3-(3-carbamoyl-4-methylphenyl)prop-2-yn-1-yl]amino]-5'-deoxyadenosine
Homo sapiens
pH 7.5, 37°C
0.0000068
5'-[(3-amino-3-carboxypropyl)[3-(3-carbamoylphenyl)prop-2-yn-1-yl]amino]-5'-deoxyadenosine
Homo sapiens
pH 7.5, 37°C
0.000052
5'-[(3-amino-3-carboxypropyl)[3-(5-carbamoyl-2-methoxyphenyl)prop-2-yn-1-yl]amino]-5'-deoxyadenosine
Homo sapiens
pH 7.5, 37°C
0.1115
5'-[(4-amino-4-oxobutyl)[(naphthalen-2-yl)methyl]amino]-5'-deoxyadenosine
Homo sapiens
pH 8.4, 37°C
0.0526
5'-[(5-amino-5-oxopentyl)[(naphthalen-2-yl)methyl]amino]-5'-deoxyadenosine
Homo sapiens
pH 8.4, 37°C
0.014 - 0.029
5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine
0.0234
5'-[[(3S)-3-amino-3-carboxypropyl][(3-carboxyphenyl)methyl]amino]-5'-deoxyadenosine
Homo sapiens
pH 8.4, 37°C
0.000043
5'-[[(3S)-3-amino-3-carboxypropyl][4-(3-carbamoylphenyl)butyl]amino]-5'-deoxyadenosine
Homo sapiens
pH 7.5, 37°C
0.0012
5-amino-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.000588
6-(methylamino)pyridine-3-carboxamide
Homo sapiens
pH 7.5, 37°C
0.0057
6-fluoro-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.000837
6-methoxy-4-methylpyridine-3-carboxamide
Homo sapiens
pH 7.5, 37°C
0.058
7-(3-carbamoylphenyl)hept-6-ynoic acid
Homo sapiens
pH 8.6, 37°C
0.0026
7-amino-1-methylquinolin-1-ium
Homo sapiens
pH 8.6, 37°C
0.025
N'-methyl-nicotinamide
Homo sapiens
pH 8.6, 37°C
0.06
N1-methylnicotinamide
Homo sapiens
-
IC50 0.06 mM for human protein, 0.03 mM for recombinant protein
0.115
norharmane
Homo sapiens
pH 8.6, 37°C
0.0012 - 0.075
S-adenosyl-L-homocysteine
0.0039 - 0.017
sinefungin