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2.1.1.1: nicotinamide N-methyltransferase

This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
nicotinamide
 +
H+
=
S-adenosyl-L-homocysteine
 +
1-methylnicotinamide

Synonyms

ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.1 nicotinamide N-methyltransferase

Expression

Expression on EC 2.1.1.1 - nicotinamide N-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
exposure of BEAS-2B cells to induces NNMT repression at both the protein and mRNA levels
exposure to nickel induces NNMT repression at both the protein and mRNA levels
expression is significantly elevated in a number of cancers, expression is significantly increased in the brains of patients who have died of Parkinson’s disease
-
expression is significantly elevated in the diaphragm and quadriceps muscles of patients with chronic obstructive pulmonary disease. The relative induction of expression is greater in the quadriceps muscle (10-fold) than it is in the diaphragm(2-fold). Expression correlates negatively with these verity of chronic obstructive pulmonary disease and limb muscle wasting. Expression in skeletal myoblasts is significantly induced by IL-6, transforming growth factor beta, and tumor necrosis factor-alpha. Overexpression in myoblasts triggers a significant increase in proliferation and migration, but has no influence on cell death
-
expression is upregulated in the cutaneous squamous cell carcinoma SCC-12 cell line
gain-of-function non-coding micro-RNA-1291 miR-1291-altered PANC-1 cell function is associated with the increase in N-methylnicotinamide level and NNMT expression
-
hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in mice
highly upregulated inclear cell renal carcinoma cell
-
patients with manifest type 2 diabetes have an approximately twofold higher NNMTexpression both in omental and subcutaneous white adipose tissue compared with controls
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
The activity levels are statistically significantly higher in oral squamous cell carcinoma than in adjacent normal oral mucosa
-
the enzyme is induced by nicotinic acid in adipose tissue
-
the enzyme is induced by nicotinic acid in white adipose tissue, but chronic treatment does not cause hyperhomocysteinemia, overview
-
the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer
the NNMT gene is differentially upregulated in nasopharyngeal cancer tissues
-