2.1.1.1: nicotinamide N-methyltransferase
This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT
ECTree
Advanced search results
Application
Application on EC 2.1.1.1 - nicotinamide N-methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
analysis
development of a NNMT activity assay using ultra-high-performance hydrophilic interaction chromatography. It allows for rapid separation of the reaction products, coupled with quadrupole time-of-flight mass spectrometric detection for enhanced sensitivity and enabling high-throughput sample analysis
diagnostics
drug development
-
the enzyme might be a good molecular target for lung cancer therapy
medicine
pharmacology
-
high enzyme expression levels in oral squamous cell carcinoma cells indicates a favourable prognosis in patients, whereas the absence of NNMT expression constitutes a hallmark of aggressive biological behaviour
diagnostics
-
NNMT is useful as a biomarker of lung cancer, stages I-III. The sensitivity of the detection in non-small cell lung cancer cells at 90% specficity increases from 25% to 32% when NNMT is used in combination with carcinoembryonic antigen, method development, overview
diagnostics
-
the enzyme may serve as a potential biomarker for tumor diagnosis and a therapeutic target
-
enzyme protein level is significantly elevated in younger patients with Parkinson's disease
medicine
-
significantly increased levels of enzyme protein and activity in brain of patients with Parkinson´s disease, study on brain tissue distribution
medicine
-
enzyme activity correlates with tumor growth and morphological changes resembling apoptosis
medicine
-
enzyme activity correlates with tumor growth and morphological changes resembling apoptosis
medicine
-
levels of hepatic enzyme activity are closely associated with the degree of weight loss, use as marker of cancer cachexia
medicine
-
expression of enzyme is significantly higher in cerebellum of patients with idiopathic Parkinson's disease than in control groups
medicine
-
significantly higher enzyme activity in papillary thyroid carcinoma cell lines than in controls
medicine
epidemiologic study to analyze risk factors for complex congenital heart defects (CHDs) and multifactorial aetiology
medicine
-
inhibition of NNMT activity is a promising therapeutic target for cancer therapy
medicine
-
the enzyme may serve as a potential biomarker for tumor diagnosis and a therapeutic target
medicine
down-regulation of NNMT in colorectal cancer HT-29 cells diminishes 5-fluorouracil resistance, while overexpression of NNMT in SW-480 cells enhances it
medicine
patients with manifest type 2 diabetes have an approximately twofold higher NNMT expression both in omental and subcutaneous white adipose tissue compared with controls. Plasma 1-methylnicotinamide concentration correlates with increased tissue NNMT expression and the degree of insulin resistance
medicine
the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer. The overexpression of NNMT enhances PC-3 cell viability, invasion and migration capacity. The overexpression of NNMT significantly increases the mRNA level of sirtuin 1 in PC-3 cells. Nicotinamide treatment significantly suppresses the expression of SIRT1 even in PC-3 cells transfected with adeno-associated virus-NNMT
pharmacology
-
the enzyme might be a good molecular target for lung cancer therapy