1.8.98.2: sulfiredoxin

This is an abbreviated version!
For detailed information about sulfiredoxin, go to the full flat file.

Word Map on EC 1.8.98.2

1.8.98.2

peroxiredoxins

hyperoxidation

thioredoxins

overoxidized

sulfenic

peroxidatic

txnrd1

sulfinylated

deglutathionylation

prxiii

prdxs

cys-so2h

medicine

drug development

Reaction

+ 2 R-SH =

Synonyms

AtSrx, cysteine-sulfinic acid reductase, neoplastic progression 3, peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase, protein cysteine sulfinic acid reductase, Srx, Srx1, Srxn1, sulfiredoxin, sulfiredoxin 1, sulfiredoxin-1, sulphiredoxin

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.98 With other, known, physiological acceptors

1.8.98.2 sulfiredoxin

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Results	in table
1	Activating Compound
1793	AA Sequence
5	Application
1	CAS Registry Number
19	Cloned(Commentary)
17	Cofactor
4	Crystallization (Commentary)
228	Disease/ Diagnostics
8	Expression
18	General Information
2	IC50 Value
9	Inhibitors
8	KM Value [mM]
20	Localization
11	Metals/Ions
6	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
50	Organism
26	PDB ID
3	pH Optimum
3	pI Value
36	Protein Variants
9	Purification (Commentary)
1	Reaction
17	Reaction Type
44	Reference
40	Source Tissue
73	Substrates and Products (Substrate)
3	Subunits
54	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.8.98.2 - sulfiredoxin

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cortical glial cell, in both neurons and glia, Nrf2 expression and treatment with chemopreventive Nrf2 activators, including 3H-1,2-dithiole-3-thione and sulforaphane, upregulate sulfiredoxin, an enzyme responsible for reducing hyperoxidized peroxiredoxins

659421, 698928, 698993

Srx is highly expressed in primary specimen of lung cancer patients

derived from squamous cell carcinoma

765061

neuron

Rattus norvegicus

cortical neuron, in both neurons and glia, Nrf2 expression and treatment with chemopreventive Nrf2 activators, including 3H-1,2-dithiole-3-thione and sulforaphane, upregulate sulfiredoxin, an enzyme responsible for reducing hyperoxidized peroxiredoxins