1.8.98.1: dihydromethanophenazine:CoB-CoM heterodisulfide reductase

This is an abbreviated version!
For detailed information about dihydromethanophenazine:CoB-CoM heterodisulfide reductase, go to the full flat file.

Reaction

Synonyms

Co:CoM-S-S-CoB oxidoreductase system, CO:heterodisulfide oxidoreductase system, CoB-S-S-CoM reductase, Coenzyme B-Coenzyme M heterodisulfide reductase, coenzyme F420:heterodisulfide oxidoreductase, CoM-S-S-HTP reductase, DsrE2A, DsrK, F420H2-dependent CoM-S-S-HTP reductase, F420H2-dependent heterodisulfide reductase, Fdx:CoMS-SCoB oxidoreductase, ferredoxin- and F420H2-dependent, electron-bifurcating, heterodisulfide reductase, H2:heterodisulfide oxidoreductase, HDR, HdrA, hdrA2B2C2, HdrABC, HdrB, HdrB1, HdrB2, HdrC, HdrC1, HdrC2, HdrD, heterodisulfide reductase, More, SdhC, soluble heterodisulfide reductase, Vlud

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.98 With other, known, physiological acceptors

                1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase

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Results	in table
2	Activating Compound
2040	AA Sequence
2	CAS Registry Number
8	Cloned(Commentary)
24	Cofactor
1	Crystallization (Commentary)
4	Expression
11	General Information
1	General Stability
10	Inhibitors
20	KM Value [mM]
18	Localization
20	Metals/Ions
20	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
152	Organism
2	Oxidation Stability
6	Pathway
28	PDB ID
4	pH Optimum
1	pH Range
1	pI Value
1	Posttranslational Modification
3	Protein Variants
20	Purification (Commentary)
2	Reaction
5	Reaction Type
51	Reference
5	Source Tissue
14	Specific Activity [micromol/min/mg]
2	Storage Stability
81	Substrates and Products (Substrate)
16	Subunits
97	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Cofactor

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Cofactor on EC 1.8.98.1 - dihydromethanophenazine:CoB-CoM heterodisulfide reductase

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

coenzyme F420

2 entries

cytochrome b

3 entries

-

FAD

9 entries

Fe-S center

Methanothermobacter marburgensis

Q50755

subunit HdrB contains a Fe-S cluster fixed by cysteines of two cysteine-rich CCG domain sequence motifs, CX31-39CCX35-36CXXC. Electron paramagnetic resonance spectra are consistent with with the attachment of the substrate to the cluster in HdrABC and infer that the cluster's magnetic properties arise from the CCG binding motif

725558

heme

2 entries

[2Fe-2S]-center

Methanosarcina acetivorans

-

-

743210

[4Fe-4S]-center

2 entries

additional information

5 entries

-

coenzyme F420

Methanococcus voltae

-

-

654386

coenzyme F420

Methanosarcina acetivorans

-

-

743210

cytochrome b

Methanosarcina barkeri

P96796

the 23000 da subunit is cytochrome b

655402

-

cytochrome b

Methanosarcina barkeri

-

the 23000 Da subunit is the cytochrome b, cytochrome b serves as electron donor for the heterodisulfide reduction

655400

-

cytochrome b

Methanosarcina barkeri

-

the H2:heterodisulfide oxidoreductase multienzyme complex contains 3.2 nmol cytochrome b per mg protein

655396

-

FAD

Methanosarcina barkeri

-

-

667866

FAD

Desulfovibrio vulgaris

-

-

742382

FAD

Methanosarcina thermophila

-

-

667866

FAD

Methanosarcina acetivorans

-

-

743210

FAD

Methanothermobacter marburgensis

-

-

667866

FAD

Methanothermobacter thermautotrophicus

-

1 mol H2: heterodisulfide oxidoreductase complex with MW 250000 Da contains approximately 0.9 mol FAD

655398

FAD

Methanothermobacter thermautotrophicus

-

enzyme contains 4 mol FAD per mol of native enzyme

639391

FAD

Methanosarcina barkeri

-

the enzyme contains 3 mol of FAD per mg of protein

655400

FAD

Methanosarcina barkeri

-

the H2:heterodisulfide oxidoreductase multienzyme complex contiams 0.6 nmol per mg of protein

655396

heme

Methanosarcina thermophila

-

contains two b-hemes. Only the low spin heme and the high potential FeS cluster are involved in reduction of N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine

639394

heme

Methanosarcina thermophila

-

the enzyme contains two discrete b-type hemes in the small subunit. One heme is high-spin and has a high midpoint potential, -23 mV, whereas the other heme is low-spin and exhibits a relatively low midpoint potential, -180 mV

639393

[4Fe-4S]-center

Methanosarcina acetivorans

-

-

743210

[4Fe-4S]-center

Methanomassiliicoccus luminyensis

-

-

742500

additional information

Methanosarcina thermophila

-

coenzyme F420 is not required

655823

-

additional information

Methanothermobacter thermautotrophicus

-

no reaction with conenzyme F420

655398

-

additional information

Methanosarcina barkeri

P96796

not a flavoenzyme, both subunits lack an FAD-binding motif

655402

-

additional information

Methanosarcina barkeri

-

not a flavoenzyme, both subunits lack an FAD-binding motif

655402

-

additional information

Methanosarcina barkeri

-

the H2:heterodisukfide oxidoreductase complex does not mediate the reduction of coenzyme F420 with H2 nor the oxidation of reduced coenzyme F420 with the heterodisulfide

655396

-