1.8.4.12: peptide-methionine (R)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.

Reaction

Synonyms

1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.12 peptide-methionine (R)-S-oxide reductase

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8	Activating Compound
46160	AA Sequence
3	Application
69	Cloned(Commentary)
108	Cofactor
9	Crystallization (Commentary)
255	Disease/ Diagnostics
12	Expression
85	General Information
10	Inhibitors
34	kcat/KM [mM/s]
68	KM Value [mM]
100	Localization
45	Metals/Ions
22	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
378	Organism
2	Pathway
33	PDB ID
23	pH Optimum
1	pH Range
2	pI Value
85	Protein Variants
41	Purification (Commentary)
42	Reaction
262	Reference
141	Source Tissue
55	Specific Activity [micromol/min/mg]
1	Storage Stability
323	Substrates and Products (Substrate)
30	Subunits
417	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
65	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase

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SYSTEMATIC NAME

IUBMB Comments

peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming]

The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for reduction of the R-form of methionine S-oxide, with higher activity being observed with L-methionine S-oxide than with D-methionine S-oxide [9]. While both free and protein-bound methionine (R)-S-oxide act as substrates, the activity with the peptide-bound form is far greater [10]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase, are found within the same protein whereas in other species, they are separate proteins [3,5]. The reaction proceeds via a sulfenic-acid intermediate [5,10]. For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but thionein works well [11]. The enzyme from some species contains selenocysteine and Zn2+.