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1.8.4.12: peptide-methionine (R)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.

Word Map on EC 1.8.4.12

Reaction

L-methionine (R)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.12 peptide-methionine (R)-S-oxide reductase

Specific Activity

Specific Activity on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000029
-
wild-type strain RN450, substrate L-methionine (R)-sulfoxide
0.00003
-
msrA2 knockout strain RN450, substrate L-methionine (R)-sulfoxide
0.000046
-
purified recombinant wild-type cysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells, substrates are L-methionine-(R)-S-oxide and thioredoxin
0.000085
-
enzyme form Mem-R,S-Msr
0.00009
-
enzyme form Mem-R,S-Msr, substrate sulindac
0.00022
-
MsrB, substrate N-acetyl-L-methionine-(R)-sulfoxide
0.0004
-
membrane vesicles, substrate N-acetyl-L-methionine-(R)-sulfoxide
0.0007
-
kidney, substrate L-methionine (R)-sulfoxide
0.0012
-
msrA1 knockout strain RN450, substrate L-methionine (R)-sulfoxide
0.0015
-
msrA1/msrA2 double knockout strain RN450, substrate L-methionine (R)-sulfoxide
0.0019
-
liver, substrate L-methionine (R)-sulfoxide
0.002
-
purified recombinant wild-type cysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells, substrates are L-methionine-(R)-S-oxide and DTT
0.0048
-
wild-type strain, substrate L-methionine (R)-sulfoxide
0.01
-
purified recombinant wild-type isozyme MsrB2 expressed in Escherichia coli, substrates are L-methionine-(R)-S-oxide and thioredoxin
0.023
0.045
-
purified recombinant wild-type selenocysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells, substrates are L-methionine-(R)-S-oxide and thioredoxin
0.055
in 100 mM sodium phosphate, at 37°C and pH 6.5
0.071
substrate: cytosolic human thioredoxin 1
0.074
in 50 mM carbonate-bicarbonate, at 37°C and pH 10.0
0.075
purified recombinant MsrA/MsrB tandem domain, substrate L-methionine (R)-sulfoxide
0.085
purified recombinant CBS-1, substrate L-methionine (R)-sulfoxide
0.092
purified recombinant CBS-1, substrate L-methionine (R)-sulfoxide
0.106
substrate: cytosolic human thioredoxin 1
0.119
in 50 mM Tris-HCl, at 37°C and pH 7.6
0.12
substrate: Escherichia coli thioredoxin
0.128
substrate: mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptid
0.142
substrate: Escherichia coli thioredoxin
0.17
-
purified recombinant wild-type selenocysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells, substrates are L-methionine-(R)-S-oxide and DTT
0.173
substrate: mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptid
0.179
substrate: dithiothreitol
0.228
in 100 mM sodium phosphate, at 37°C and pH 7.5
0.267
in 50 mM Tris-HCl, at 37°C and pH 8.0
0.272
in 50 mM carbonate-bicarbonate, at 37°C and pH 9.6
0.291
substrate: dithiothreitol
0.386
-
purified recombinant wild-type isozyme MsrB2 expressed in Escherichia coli, substrates are L-methionine-(R)-S-oxide and DTT
0.446
in 50 mM Tris-HCl, at 37°C and pH 8.6
0.452
-
purified recombinant wild-type isozyme MsrB3 expressed in Escherichia coli, substrates are L-methionine-(R)-S-oxide and DTT
0.462
in 50 mM carbonate-bicarbonate, at 37°C and pH 9.2
0.484
in 50 mM Tris-HCl, at 37°C and pH 9.0
1.78
-
purified recombinant PilB, substrate L-methionine (R)-sulfoxide
12
-
recombinant wild-type MsrB domain, cosubstrate thioredoxin
170
-
recombinant wild-type MsrA/MsrB, cosubstrate thioredoxin
3
-
recombinant wild-type MsrB domain, cosubstrate dithiothreitol
4.2
-
recombinant wild-type MsrA/MsrB, cosubstrate dithiothreitol
additional information