1.8.3.2: thiol oxidase
This is an abbreviated version!
For detailed information about thiol oxidase, go to the full flat file.
Word Map on EC 1.8.3.2
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1.8.3.2
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hepatocytes
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intermembrane
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oxidases
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relay
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qsoxs
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thioredoxin
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redox-active
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hepatectomy
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hepatotrophic
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reoxidized
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hepatectomized
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flavoenzyme
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fad-dependent
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fad-binding
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oxidoreductins
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flavin-linked
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redox-regulated
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isoalloxazine
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3h-tdr
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diagnostics
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medicine
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nutrition
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analysis
- 1.8.3.2
- hepatocytes
-
intermembrane
- oxidases
-
relay
-
qsoxs
- thioredoxin
-
redox-active
-
hepatectomy
-
hepatotrophic
-
reoxidized
-
hepatectomized
-
flavoenzyme
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fad-dependent
-
fad-binding
-
oxidoreductins
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flavin-linked
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redox-regulated
- isoalloxazine
-
3h-tdr
- diagnostics
- medicine
- nutrition
- analysis
Reaction
2 R'C(R)SH
+
Synonyms
Ac92, AcMNPV P33, ALR, ALRp, AtSOX, augmenter of liver regeneration, DTT-oxidase, E10R, egg white oxidase, Ero1, Ero1p, ERV/ALR sulfhydryl oxidase, Erv1, Erv1p, Erv2, ERv2p, FAD-linked sulfhydryl oxidase, FAD-linked sulfhydryl oxidase ALR, FAD-sulfhydryl oxidase, flavin adenine dinucleotide-linked sulfhydryl oxidase, flavin-dependent sulfhydryl oxidase, GmQSOX1, GmQSOX2, hepatic regenerative stimulator substance, hepatopoietin, mitochondrial FAD-linked sulfhydryl oxidase ERV1, More, neuroblastoma-derived sulfhydryl oxidase, oxidase, thiol, P33, pB119L, protein pB119L, QSCN6, QSOX, QSOx1, QSOX1b, QSOX2, QSOX3, Quiescin Q6, quiescin Q6 sulfhydryl oxidase, quiescin Q6 sulfhydryl oxidase 1, quiescin Q6/sulfhydryl oxidase, quiescin sulfhydryl oxidase, quiescin sulfhydryl oxidase 1, quiescin sulhydryl oxidase, quiescin-like flavin-dependent sulfhydryl oxidase, Quiescin-sulfhydryl oxidase, quiescin/sulfhydryl oxidase, quiescin/sulfhydryl oxidase 1b, quiescin/sulphydryl oxidase, rQSOX, sfALR, SOX, Sox1, Sox2, SOXN, sulfhydryl oxidase, sulfhydryl oxidase SOx-3, sulfhydryl oxidase, P33, sulphydryl oxidase, thiol oxidase Erv1, thiooxidase
ECTree
1.8.3.2 thiol oxidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.8.3.2 - thiol oxidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 R'C(R)SH + O2
R'C(R)S-S(R)CR' + H2O2
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the enzyme catalyze the oxidation of thiol substrates with the reduction of molecular oxygen to hydrogen peroxide
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?
insulin A and B chains + O2
disulfide of insulin A and B chains + H2O2
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-
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?
riboflavin-binding protein + O2
riboflavin-binding protein disulfide + H2O2
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-
-
-
?
R-SH + O2
R-S-S-R + H2O2
enzyme is essential for biogenesis of mitochondrial and cytosolic iron sulfur cluster assembly
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ir
R-SH + O2
R-S-S-R + H2O2
enzyme plays a role in synaptic strengthening and in redox activities in the brain
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ir
R-SH + O2
R-S-S-R + H2O2
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enzyme plays a significant role in oxidative folding of a large variety of proteins
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-
?
R-SH + O2
R-S-S-R + H2O2
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oxidation of protein or peptide sulfhydryl groups to disulfides with a concomitant reduction of molecular oxygen to peroxide
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ir
R-SH + O2
R-S-S-R + H2O2
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enzyme might counterbalance the plasmin reductase in extracellular reductive processes
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ir
R-SH + O2
R-S-S-R + H2O2
enzyme plays a significant role in oxidative folding of a large variety of proteins
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-
?
R-SH + O2
R-S-S-R + H2O2
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enzyme plays a role in secreted peptide/protein folding in the brain
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-
?
R-SH + O2
R-S-S-R + H2O2
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enzyme plays a role in the extracellular matrix as well as in intracellular folding of secreted proteins or hormons like LH and FSH, enzyme acts as an endogenous redox modulator of hormonal secretion, enzyme expression is regulated by estrogens
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ir
R-SH + O2
R-S-S-R + H2O2
enzyme plays a significant role in oxidative folding of a large variety of proteins
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-
?
additional information
?
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sulfhydryl oxidase Sox-3 can be implicated in the negative cell cycle control
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-
?
additional information
?
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sulfhydryl oxidase Sox-3 can be implicated in the negative cell cycle control
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?
additional information
?
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the enzyme may play an important role in the introduction of disulfide bridges in egg white proteins
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?
additional information
?
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possible role for oxidase in protein secretory pathway
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-
?
additional information
?
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preferred substrates are protein or peptide sulfhydryl groups, even of denatured cytoplasmic proteins, low molecular weight thiols, such as cysteine or glutathione, are poorer substrates
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?
additional information
?
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the enzyme may provide a crucial switch for the regulation of receptor-Ck-dependent mevalonate pathway
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?
additional information
?
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enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis
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?
additional information
?
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enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis
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?
additional information
?
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enzyme might communicate with the respiratory chain via the mediation of cytochrome c
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?
additional information
?
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the enzyme is involved in mitochondrial biogenesis
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?
additional information
?
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nuclear sfALR interacts with the Jun activation-domain binding protein (JAB1) mediating the interaction between ALR and activator protein-1 (AP-1) via the phosphorylation of c-Jun
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?
additional information
?
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quiescin-sulfhydryl oxidase (QSOX) catalyzes the facile direct introduction of disulfide bonds into unfolded, reduced proteins with the reduction of molecular oxygen to generate hydrogen peroxide. Enzyme QSOX preferentially binds the scrapie isoform prion PrPSc from prion-infected human brains, but not PrPC from uninfected brains, the affinity of QSOX for monomer is significantly lower than that for octamer. QSOX exhibits much lower affinity for N-terminally truncated murine prion protein (PrP89-230) than for the full-length murine prion protein (PrP23-231), suggesting that the N-terminal region of prion protein is critical for the interaction of prion protein with QSOX
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?
additional information
?
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enzyme appears to protect sperm structure and function against damage by endogeneous sulfhydryls
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?
additional information
?
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essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic but not of mitochondrial Fe-S proteins
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?
additional information
?
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Erv2p functions in the generation of microsomal disulfide bonds acting in parallel with Ero1p, the essential FAD-dependent oxidase of protein disulfide isomerase
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?
additional information
?
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Evr1p is involved in cellular iron homeostasis, physiological role of the ERV1/ALR family enzymes, overview
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?
additional information
?
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the enzyme is involved in mitochondrial biogenesis
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?
