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1.8.1.8: protein-disulfide reductase

This is an abbreviated version!
For detailed information about protein-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.8

Reaction

protein-dithiol
+
NAD(P)+
=
protein-disulfide
+
NAD(P)H
+
H+

Synonyms

AhpF, disulfide reductase, EC 1.6.4.4, ERdj5, ERp16, glutaredoxin, HvTrxh2, insulin-glutathione transhydrogenase, LpdA, MA3736, MA_1658, MdrA, methanoredoxin, More, NAD(P)H:protein-disulfide oxidoreductase, NADH-linked disulfide reductase, panthethine 4'4-diphosphate-specific reductase, PDI reductase, PDO, PfPDO, PH1130 protein, PhDsb, protein disulfide isomerase reductase, protein disulfide oxidoreductase, protein disulfide reductase, protein-disulfide oxidoreductase, protein-disulfide reductase (NAD(P)H), reductase, protein disulfide, thiol-disulfide oxidoreductase, TON_0319, TTC0486, WhiB1, WhiB1/Rv3219

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.8 protein-disulfide reductase

Natural Substrates Products

Natural Substrates Products on EC 1.8.1.8 - protein-disulfide reductase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
peroxiredoxin disulfide + NADH
reduced peroxiredoxin + NAD+
show the reaction diagram
-
enzyme recycles peroxiredoxin AhpC, enzyme acts in a catalytic cycle reaction together with peroxidase forming the bacterial alkyl hydroperoxide reductase system, formerly known as F-52a
-
-
ir
protein disulfide + NAD(P)H
protein dithiol + NAD(P)+
show the reaction diagram
-
-
-
-
r
protein disulfide + NADH
protein dithiol + NAD+
show the reaction diagram
-
the activity of MdrA and the organization of mdrA in a transcriptional unit with oxidative stress genes are consistent with a role in the oxidative stress response of Methanosarcina acetivorans
-
-
?
additional information
?
-
-
the disulfide reductase system varies with the organism, overview
-
-
?