1.8.1.8: protein-disulfide reductase

This is an abbreviated version!
For detailed information about protein-disulfide reductase, go to the full flat file.

Reaction

Synonyms

AhpF, disulfide reductase, EC 1.6.4.4, ERdj5, ERp16, glutaredoxin, HvTrxh2, insulin-glutathione transhydrogenase, LpdA, MA3736, MA_1658, MdrA, methanoredoxin, More, NAD(P)H:protein-disulfide oxidoreductase, NADH-linked disulfide reductase, panthethine 4'4-diphosphate-specific reductase, PDI reductase, PDO, PfPDO, PH1130 protein, PhDsb, protein disulfide isomerase reductase, protein disulfide oxidoreductase, protein disulfide reductase, protein-disulfide oxidoreductase, protein-disulfide reductase (NAD(P)H), reductase, protein disulfide, thiol-disulfide oxidoreductase, TON_0319, TTC0486, WhiB1, WhiB1/Rv3219

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.8 protein-disulfide reductase

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Results	in table
14437	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
21	Cofactor
6	Crystallization (Commentary)
363	Disease/ Diagnostics
1	General Information
2	General Stability
13	Inhibitors
2	Ki Value [mM]
17	KM Value [mM]
1	Localization
2	Metals/Ions
11	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
35	Organism
82	PDB ID
4	pH Optimum
2	pH Range
4	pH Stability
3	pI Value
1	Protein Variants
10	Purification (Commentary)
2	Reaction
8	Reaction Type
34	Reference
17	Source Tissue
2	Specific Activity [micromol/min/mg]
7	Storage Stability
53	Substrates and Products (Substrate)
17	Subunits
56	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
6	Temperature Stability [°C]
12	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.8.1.8 - protein-disulfide reductase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2'-phospho-ADP-ribose

Mycobacterium tuberculosis

-

inhibition of 2,6-dimethyl-1,4-benzoquinone reduction

659424

AgNO3

Pisum sativum

-

0.009 mM, 66% inhibition

437710

arsenite

2 entries

CdSO4

Pisum sativum

-

0.005 mM, 91% inhibition

437710

CuSO4

Pisum sativum

-

0.015 mM, complete inhibition

437710

HgCl2

Pisum sativum

-

0.002 mM, 92% inhibition

437710

iodoacetate

Pisum sativum

-

0.054 mM, 57% inhibition

437710

N-ethylmaleimide

Priestia megaterium

-

-

680424

NADP+

Mycobacterium tuberculosis

-

inhibition of 2,6-dimethyl-1,4-benzoquinone reduction

659424

p-chloromercuribenzoate

Pisum sativum

-

0.054 mM, 88% inhibition

437710

ZnSO4

Pisum sativum

-

0.003 mM, 82% inhibition

437710

additional information

Salmonella enterica subsp. enterica serovar Typhimurium

-

enzyme is inhibited by alkylation of either pair of Cys residues, i.e. Cys129-Cys132, or Cys345-Cys348

657677

-

arsenite

Pisum sativum

-

0.15 mM, complete inhibition

437710

arsenite

Priestia megaterium

-

-

680424