1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.7 glutathione-disulfide reductase

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Results	in table
43	Activating Compound
13813	AA Sequence
7	Application
1	CAS Registry Number
31	Cloned(Commentary)
378	Cofactor
19	Crystallization (Commentary)
2453	Disease/ Diagnostics
25	Expression
51	General Information
69	General Stability
117	IC50 Value
526	Inhibitors
28	kcat/KM [mM/s]
149	Ki Value [mM]
241	KM Value [mM]
112	Localization
27	Metals/Ions
136	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
559	Organism
1	Oxidation Stability
5	Pathway
38	PDB ID
88	pH Optimum
21	pH Range
22	pH Stability
7	pI Value
4	Posttranslational Modification
15	Protein Variants
103	Purification (Commentary)
39	Reaction
4	Reaction Type
284	Reference
1	Renatured (Commentary)
216	Source Tissue
120	Specific Activity [micromol/min/mg]
48	Storage Stability
440	Substrates and Products (Substrate)
119	Subunits
271	Synonyms
1	Systematic Name
62	Temperature Optimum [°C]
7	Temperature Range [°C]
47	Temperature Stability [°C]
71	Turnover Number [1/s]

pH Optimum

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of the Enzyme Summary Page.

pH Optimum on EC 1.8.1.7 - glutathione-disulfide reductase

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4.5

Escherichia coli

-

NADH + GSSG

394737

5

2 entries

5 - 5.5

Rattus norvegicus

-

NADH + GSSG

394750

5.7

Homo sapiens

-

NADH + GSSG

394725

6

2 entries

6.5

6 entries

6.5 - 7.5

Setaria cervi

-

broad pH optimum centered around pH 7.0

725772

6.6 - 7.6

Saccharomyces cerevisiae

-

-

394709

6.8

3 entries

6.8 - 7.6

Homo sapiens

-

-

394712

6.9

3 entries

7

16 entries

7.2 - 7.3

Hemicentrotus pulcherrimus

-

-

394752

7.2 - 7.6

Arabidopsis thaliana

-

-

701018

7.3

Bos taurus

-

-

660339

7.4

3 entries

7.5

9 entries

7.5 - 8

Triticum turgidum subsp. durum

-

-

394773

7.5 - 8.2

Rhodospirillum rubrum

-

-

394755

7.7

Pisum sativum

-

root enzyme

394732

7.8

3 entries

7.8 - 8.6

3 entries

7.9

Oryza sativa

-

-

394754

8

10 entries

8.1

2 entries

8.2

2 entries

8.5 - 9

Spinacia oleracea

-

-

394745

9

Anabaena sp.

-

-

394741

5

Moniezia expansa

-

NADH + GSSG

394756

5

Sus scrofa

-

NADH + GSSG

394721, 394722

6

Homo sapiens

-

NADH + GSSG

394727

6

Phycomyces blakesleeanus

-

NADH

394719

6.5

Acidithiobacillus ferrooxidans

-

NADPH + GSSG

394771

6.5

Equus caballus

-

NADH + glutathione

394757

6.5

Homo sapiens

P00390

recombinant glutathione-trypanothione reductase-like enzyme

394776

6.5

Physarum polycephalum

Q9NL96

-

659594

6.5

Rattus norvegicus

-

-

713468

6.5

Trachemys scripta

-

-

675954

6.8

Homo sapiens

-

broad optimum

393993

6.8

Homo sapiens

-

NADPH + GSSG

394725, 394727

6.8

Plasmodium falciparum

-

-

391653

6.9

Homo sapiens

P00390

assay at

659698

6.9

Oryctolagus cuniculus

-

-

394734

6.9

Plasmodium falciparum

-

assay at

659698

7

Achromobacter starkeyi

-

-

394713

7

Acidithiobacillus thiooxidans

-

-

394748

7

Allochromatium vinosum

-

NADH + GSSG

394751

7

Anabaena sp.

-

NADPH + GSSG

394767, 394772

7

Bos taurus

-

-

394711, 394742, 688951

7

Bos taurus

-

assay at

659860

7

Equus caballus

-

NADPH + GSSG

394757

7

Gallus gallus

-

-

657570

7

Limnospira maxima

-

-

394733

7

Planiliza haematocheilus

-

-

764549

7

Rattus norvegicus

-

-

394711

7

Rattus norvegicus

-

assay at

658797, 660485

7

Rattus norvegicus

-

NADPH + GSSG

393993, 394750

7

Saccharomyces cerevisiae

-

NADPH + GSSG

393993

7

Setaria cervi

-

-

726094

7

Sus scrofa

-

NADPH + GSSG

394721, 394722

7.4

Homo sapiens

P00390

assay at

659182

7.4

Moniezia expansa

-

NADPH + GSSG

394756

7.4

Plasmodium falciparum

-

assay at

659182

7.5

Camelus dromedarius

-

-

724919

7.5

Cyberlindnera mrakii

-

NADPH + GSSG

394770

7.5

Escherichia coli

-

NADPH + GSSG

394737

7.5

Homo sapiens

-

assay at

657878

7.5

Phycomyces blakesleeanus

-

NADPH + GSSG

394719

7.5

Populus trichocarpa

A0A2K1XHK8, A0A2K2BSL2, A9PHY8

enzyme variant PtGR1.1

765618

7.5

Psychrobacter sp. ANT206

-

-

764906

7.5

Riccia fluitans

-

assay at

694642

7.5

Sphingomonas sp.

WP_010214957

-

764686

7.8

Bos taurus

-

assay at

394761

7.8

Homo sapiens

-

assay at

394761

7.8

Taenia crassiceps

-

assay at

659902

7.8 - 8.6

Homo sapiens

-

broad optimum

394718

7.8 - 8.6

Saccharomyces cerevisiae

-

broad optimum

394718

7.8 - 8.6

Spinacia oleracea

-

broad optimum

394718

8

Anabaena sp.

-

NADH + GSSG

394767, 394772

8

Cenchrus americanus

A0A068EUE1

-

743274

8

Homo sapiens

-

assay at

659592

8

Oncorhynchus mykiss

-

enzyme activity in 50 mM Tris-HCl buffer (pH 8.0) is higher than in 50 mM phosphate buffer (pH 8.0)

686233

8

Phaeodactylum tricornutum

-

-

701146

8

Populus trichocarpa

A0A2K1XHK8, A0A2K2BSL2, A9PHY8

enzyme variant PtGR1.2

765618

8

Populus trichocarpa

A0A2K1XHK8, A0A2K2BSL2, A9PHY8

enzyme variant PtGR2

765618

8

Rattus norvegicus

-

-

742814

8

Saccharomyces cerevisiae

-

glutathione disulfide oxidation

393993

8

Triticum aestivum

-

NADPH + GSSG

394774

8.1

Escherichia coli

-

assay at

658730

8.1

Spinacia oleracea

-

-

394744

8.2

Chlamydomonas reinhardtii

-

-

394765

8.2

Pisum sativum

-

chloroplast enzyme

394732