1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.7 glutathione-disulfide reductase

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Results	in table
43	Activating Compound
13813	AA Sequence
7	Application
1	CAS Registry Number
31	Cloned(Commentary)
378	Cofactor
19	Crystallization (Commentary)
2453	Disease/ Diagnostics
25	Expression
51	General Information
69	General Stability
117	IC50 Value
526	Inhibitors
28	kcat/KM [mM/s]
149	Ki Value [mM]
241	KM Value [mM]
112	Localization
27	Metals/Ions
136	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
559	Organism
1	Oxidation Stability
5	Pathway
38	PDB ID
88	pH Optimum
21	pH Range
22	pH Stability
7	pI Value
4	Posttranslational Modification
15	Protein Variants
103	Purification (Commentary)
39	Reaction
4	Reaction Type
284	Reference
1	Renatured (Commentary)
216	Source Tissue
120	Specific Activity [micromol/min/mg]
48	Storage Stability
440	Substrates and Products (Substrate)
119	Subunits
271	Synonyms
1	Systematic Name
62	Temperature Optimum [°C]
7	Temperature Range [°C]
47	Temperature Stability [°C]
71	Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.8.1.7 - glutathione-disulfide reductase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

At3g54660

Arabidopsis thaliana

P42770

locus name

741986

EC 1.6.4.2

24 entries

GLR

2 entries

glutahione reductase

Bos taurus

-

-

660339

glutathione disulfide reductase

Plasmodium falciparum

-

-

391653

glutathione reductase

57 entries

glutathione reductase (NADPH)

-

-

-

-

glutathione reductase 3

Oryza sativa

Q7XEM9

-

726192

glutathione reductase Glr1

Saccharomyces cerevisiae

P41921

-

689967

glutathione S-reductase

-

-

-

-

glutathione: NADP(+) oxidoreductase

2 entries

glutathione: NADP+ oxidoreductase

2 entries

glutathione:NADP+ oxidoreductase

3 entries

Gor

Xanthomonas campestris

Q56S00

-

671698

GOR1

-

-

-

-

GOR2

-

-

-

-

GR

26 entries

GR1

3 entries

GR2

5 entries

Gr3

2 entries

GRase

-

-

-

-

GRase-1

Phaeodactylum tricornutum

-

-

701146

GRd

Homo sapiens

-

-

690134

GSH reductase

-

-

-

-

GSHR

Planiliza haematocheilus

-

-

764549

Gsr

2 entries

GSR-1

Caenorhabditis elegans

Q93379

-

743630

GSSG reductase

-

-

-

-

HCOI_01258400

Haemonchus contortus

CDJ91018

-

742462

hGR

Homo sapiens

-

-

689306

HvGR1

Hordeum vulgare

A8CCK2

-

689560

HvGR2

Hordeum vulgare

A8CCK8

-

689560

multifunctional thioredoxin-glutathione reductase

Taenia crassiceps

-

-

659902

NADPH-glutathione reductase

-

-

-

-

NADPH-GSSG reductase

-

-

-

-

NADPH-reduced GR

Homo sapiens

-

-

674440

NADPH: oxidized glutathione oxidoreductase

Homo sapiens

-

-

696681

NADPH:oxidized glutathione oxidoreductase

Homo sapiens

-

-

699224

NADPH:oxidized-glutathione oxidoreductase

8 entries

OBP29

-

-

-

-

PfGR

Plasmodium falciparum

-

-

689306

psgr

Psychrobacter sp. ANT206

-

-

764906

PtGR1.1

Populus trichocarpa

A0A2K2BSL2

-

765618

PtGR1.2

Populus trichocarpa

A9PHY8

-

765618

PtGR2

Populus trichocarpa

A0A2K1XHK8

-

765618

reductase, glutathione

-

-

-

-

SpGR

Sphingomonas sp.

WP_010214957

-

764686

TaGR1

Triticum aestivum

-

-

689560

TaGR2

Triticum aestivum

-

-

689560

TGR

4 entries

thioredoxin glutathione reductase

3 entries

thioredoxin/glutathione reductase

Rattus norvegicus

-

-

659484

TrxR3

Haemonchus contortus

CDJ91018

-

742462

EC 1.6.4.2

-

-

formerly

-

EC 1.6.4.2

Acorus calamus

-

formerly

726208

EC 1.6.4.2

Arachis hypogaea

-

formerly

726208

EC 1.6.4.2

Beta vulgaris

-

formerly

726208

EC 1.6.4.2

Bos taurus

-

formerly

712604, 723817

EC 1.6.4.2

Cajanus cajan

-

formerly

726208

EC 1.6.4.2

Citrullus lanatus

-

formerly

726208

EC 1.6.4.2

Citrus trifoliata

-

formerly

726208

EC 1.6.4.2

Cucumis melo

-

formerly

726208

EC 1.6.4.2

Cucumis sativus

-

formerly

726208

EC 1.6.4.2

Glycine max

-

formerly

726208

EC 1.6.4.2

Homo sapiens

-

formerly

673194, 696681, 699224

EC 1.6.4.2

Ipomoea batatas

-

formerly

698440

EC 1.6.4.2

Nicotiana tabacum

-

formerly

726208

EC 1.6.4.2

Oryza sativa

-

formerly

699801, 726208

EC 1.6.4.2

Oryza sativa

P48642

formerly

725689

EC 1.6.4.2

Pisum sativum

-

formerly

676198, 726208

EC 1.6.4.2

Pteris ensiformis

-

formerly

700795

EC 1.6.4.2

Pteris vittata

-

formerly

700795

EC 1.6.4.2

Saccharomyces cerevisiae

-

formerly

712997

EC 1.6.4.2

Spinacia oleracea

-

formerly

726208

EC 1.6.4.2

Triticum aestivum

-

formerly

676388, 726208

EC 1.6.4.2

Vigna radiata var. radiata

-

formerly

726208

EC 1.6.4.2

Zea mays

-

formerly

726208

GLR

Kluyveromyces lactis

-

-

698010, 726543

GLR

Kluyveromyces lactis NRRL-Y1140

-

-

-

glutathione reductase

-

-

-

-

glutathione reductase

Amphiprora kufferathii

-

-

700696

glutathione reductase

Arabidopsis thaliana

-

-

701018

glutathione reductase

Bos taurus

-

-

659860, 699884, 701093, 712604

glutathione reductase

Chlorocebus aethiops

-

-

711000

glutathione reductase

Colwellia sp.

-

-

700696

glutathione reductase

Colwellia sp. MH2

-

-

-

glutathione reductase

Cyprinus carpio

-

-

699961

glutathione reductase

Equus caballus

-

-

659860

glutathione reductase

Escherichia coli

-

-

658730, 687309

glutathione reductase

Gallus gallus

-

-

657570

glutathione reductase

Homo sapiens

-

-

657878, 658250, 659592, 659860, 671910, 673194, 673458, 674175, 674440, 677215, 686259, 688172, 690134, 690147, 696556, 696681, 699224, 699241, 711008, 712066

glutathione reductase

Homo sapiens

P00390

-

659182, 659698, 685442, 699619

glutathione reductase

Hordeum vulgare

A8CCK2, A8CCK8

-

689560

glutathione reductase

Ipomoea batatas

-

-

698440

glutathione reductase

Kluyveromyces lactis

-

-

698010

glutathione reductase

Kluyveromyces lactis NRRL-Y1140

-

-

-

glutathione reductase

Mus musculus

-

-

659860, 671910, 673031, 711362

glutathione reductase

Mus musculus

P47791

-

765496

glutathione reductase

Neospora caninum

F0VQD6

-

764886

glutathione reductase

Neospora caninum Liverpool

F0VQD6

-

-

glutathione reductase

Nicotiana tabacum

P80461

-

700776

glutathione reductase

Oryctolagus cuniculus

-

-

659860

glutathione reductase

Oryza sativa

-

-

689560, 699801

glutathione reductase

Oryza sativa

P48642

-

656625

glutathione reductase

Ovis aries

-

-

659860

glutathione reductase

Phaeodactylum tricornutum

-

-

701146

glutathione reductase

Physarum polycephalum

Q9NL96

-

659594

glutathione reductase

Pibocella sp.

-

-

700696

glutathione reductase

Pibocella sp. MH3

-

-

-

glutathione reductase

Pisum sativum

-

-

660197, 676198

glutathione reductase

Planiliza haematocheilus

-

-

764549

glutathione reductase

Plasmodium falciparum

-

-

659182, 659698, 674175, 688270, 711008

glutathione reductase

Plasmodium falciparum FcB1

-

-

-

glutathione reductase

Populus trichocarpa

A0A2K1XHK8, A0A2K2BSL2, A9PHY8

-

765618

glutathione reductase

Psychrobacter sp. ANT206

-

-

764906

glutathione reductase

Pteris ensiformis

-

-

700795

glutathione reductase

Pteris vittata

-

-

700795

glutathione reductase

Rattus norvegicus

-

-

658797, 659592, 659860, 660485, 673458, 673460, 677215, 686856, 700654, 713468

glutathione reductase

Rattus norvegicus

F1LRE1

-

761408

glutathione reductase

Rattus norvegicus Wistar

-

-

-

glutathione reductase

Riccia fluitans

-

-

694642

glutathione reductase

Saccharomyces cerevisiae

-

-

657763, 673790, 697449, 700654, 712997, 763919

glutathione reductase

Saccharomyces cerevisiae

P41921

-

765027

glutathione reductase

Saccharomyces cerevisiae ATCC 204508

P41921

-

-

glutathione reductase

Saccharomyces cerevisiae BY4742

-

-

-

glutathione reductase

Schizosaccharomyces pombe

-

-

673795

glutathione reductase

Sphingomonas sp.

WP_010214957

-

764686

glutathione reductase

Spinacia oleracea

-

-

690217

glutathione reductase

Streptococcus thermophilus

Q60151

-

764529

glutathione reductase

Sulfitobacter sp.

-

-

700696

glutathione reductase

Sulfitobacter sp. MH1

-

-

-

glutathione reductase

Trachemys scripta

-

-

675954

glutathione reductase

Triticum aestivum

-

-

676388, 689560

glutathione reductase

Vigna unguiculata

-

-

671339

glutathione reductase

Xanthomonas campestris

Q56S00

-

671698

glutathione reductase

Zea mays

-

-

689560

glutathione: NADP(+) oxidoreductase

Homo sapiens

-

-

673458

glutathione: NADP(+) oxidoreductase

Rattus norvegicus

-

-

673458, 673460

glutathione: NADP+ oxidoreductase

Homo sapiens

-

-

696556

glutathione: NADP+ oxidoreductase

Setaria cervi

-

-

725772

glutathione:NADP+ oxidoreductase

Homo sapiens

-

-

725616

glutathione:NADP+ oxidoreductase

Phaeodactylum tricornutum

-

-

701146

glutathione:NADP+ oxidoreductase

Spinacia oleracea

-

-

690217

GR

Anabaena sp.

-

-

394767

GR

Bos taurus

-

-

394768, 394769, 659860, 660339

GR

Chlamydomonas reinhardtii

-

-

394759

GR

Cyberlindnera mrakii

-

-

394770

GR

Equus caballus

-

-

659860

GR

Escherichia coli

-

-

658730

GR

Euglena gracilis

-

-

394778

GR

Euglena gracilis Z

-

-

-

GR

Homo sapiens

-

-

394763, 657878, 659592, 659860, 671910, 673194, 673458, 674175, 674440, 677215

GR

Homo sapiens

P00390

-

394776, 659182, 659698, 685442

GR

Mus musculus

-

-

659860, 671910, 673031

GR

Neospora caninum

F0VQD6

-

764886

GR

Neospora caninum Liverpool

F0VQD6

-

-

GR

Oryctolagus cuniculus

-

-

659860

GR

Oryza sativa

P48642

-

656625

GR

Ovis aries

-

-

659860

GR

Physarum polycephalum

Q9NL96

-

659594

GR

Picea rubens

-

-

394758

GR

Pisum sativum

-

-

660197, 676198

GR

Plasmodium falciparum

-

-

659182, 659698, 674175

GR

Rattus norvegicus

-

-

658797, 659592, 659860, 660485, 673458, 673460, 677215

GR

Riccia fluitans

-

-

694642

GR

Saccharomyces cerevisiae

-

-

657763, 673790

GR

Triticum aestivum

-

-

394774, 676388

GR

Triticum turgidum subsp. durum

-

-

394773

GR

Vigna unguiculata

-

-

671339

GR1

Arabidopsis thaliana

-

-

726215

GR1

Arabidopsis thaliana

-

cytosolic isoform, about 65% of the total glutathione reductase activity is attributed to isoform GR1

701018

GR1

Oryza sativa

-

chloroplastic isoform

699801

GR2

Arabidopsis thaliana

-

-

741875

GR2

Arabidopsis thaliana

-

isoform dual-targeted to chloroplasts and mitochondria, about 35% of the total glutathione reductase activity is attributed to isoform GR2

701018

GR2

Arabidopsis thaliana

P42770

-

741986

GR2

Arabidopsis thaliana Columbia

-

-

-

GR2

Oryza sativa

-

cytosolic isoform

699801

Gr3

Oryza sativa

-

chloroplastic isoform

699801

Gr3

Oryza sativa

Q7XEM9

isoform

726192

Gsr

Mus musculus

-

-

725067

Gsr

Mus musculus

P47791

-

765496

NADPH:oxidized-glutathione oxidoreductase

-

-

-

-

NADPH:oxidized-glutathione oxidoreductase

Bos taurus

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Equus caballus

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Homo sapiens

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Mus musculus

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Oryctolagus cuniculus

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Ovis aries

-

-

659860

NADPH:oxidized-glutathione oxidoreductase

Rattus norvegicus

-

-

659860

TGR

Mus musculus

-

-

696056

TGR

Schistosoma mansoni

-

-

689958

TGR

Schistosoma mansoni

Q962Y6

-

699614

TGR

Taenia crassiceps

-

-

659902

thioredoxin glutathione reductase

Mus musculus

-

-

696056

thioredoxin glutathione reductase

Schistosoma mansoni

-

chimeric enzyme able to transport reducing equivalents from NADPH to both GSH/GSSG and thioredoxin systems via the fusion of the thioredxin reductase and glutathione reductase domains

689958

thioredoxin glutathione reductase

Schistosoma mansoni

Q962Y6

multifunctional enzyme involving a fusion of two proteins, glutaredoxin and thioredoxin reductase

699614