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0.158 - 0.172
1,4-Naphthoquinone
0.114 - 0.71
5,5'-dithiobis(2-nitrobenzoic acid)
0.0858 - 0.413
6,7-dimethylquinoline-5,8-dione
0.4104 - 0.4208
6-methylquinoline-5,8-dione
0.224 - 0.404
7-methylquinoline-5,8-dione
11.6
bis-N,N'-(gamma-glutamylcystine)
-
-
0.16
diallyl trisulfide
-
-
0.00171 - 2.31
glutathione disulfide
0.25
glutathione-S-sulfonate
-
-
0.0312 - 0.0822
menadione
3.3
mixed disulfide of CoA and glutathione
-
-
1
mixed disulfide of coenzyme A and glutathione
-
-
0.234 - 0.363
quinoline-5,8-dione
0.0562 - 0.0595
quinoxaline-5,8-dione
0.5
S-allylmercaptoglutathione disulfide
-
pH 7.5, 22°C
-
0.21 - 4.58
trypanothione
additional information
additional information
-
0.158
1,4-Naphthoquinone
-
25°C
0.172
1,4-Naphthoquinone
-
25°C
0.114
5,5'-dithiobis(2-nitrobenzoic acid)
-
full length enzyme, in 100 mM potassium phosphate pH 7.0, at 25°C
0.71
5,5'-dithiobis(2-nitrobenzoic acid)
-
truncated recombinant enzyme (lacking the last two amino acids Sec597-Gly598), in 100 mM potassium phosphate pH 7.0, at 25°C
0.0858
6,7-dimethylquinoline-5,8-dione
-
25°C
0.413
6,7-dimethylquinoline-5,8-dione
-
25°C
0.4104
6-methylquinoline-5,8-dione
-
25°C
0.4208
6-methylquinoline-5,8-dione
-
25°C
0.224
7-methylquinoline-5,8-dione
-
25°C
0.404
7-methylquinoline-5,8-dione
-
25°C
0.00052
FAD
-
-
0.023
glutathione
-
erythrocyte enzyme, pH 7.0, 30°C
0.036
glutathione
-
brain enzyme, pH 7.0, 30°C
0.04
glutathione
-
liver enzyme, pH 7.0, 30°C
0.057
glutathione
-
liver enzyme
0.059
glutathione
-
liver enzyme
0.065
glutathione
-
erythrocyte enzyme
0.101
glutathione
-
calf liver enzyme, pH 7.0, 30°C
0.117
glutathione
-
brain enzyme
5.9
glutathione
-
purified enzyme, at pH 7.0 and 22°C
6.8
glutathione
-
crude enzyme, at pH 7.0 and 22°C
7.7
glutathione
-
chloroplast enzyme
8.2
glutathione
-
root enzyme
0.00171
glutathione disulfide
enzyme variant GR1.2, pH 7.6, 22°C
0.0123
glutathione disulfide
-
in 50 mM potassium phosphate buffer (pH 7.0)
0.0138
glutathione disulfide
-
in 50 mM potassium phosphate buffer (pH 7.0)
0.015
glutathione disulfide
-
pH 7.8, 25°C
0.01546
glutathione disulfide
enzyme variant GR1.1, pH 7.6, 22°C
0.025
glutathione disulfide
-
-
0.027
glutathione disulfide
-
enzyme from unfrozen state, presence of glucose, pH 7.2, 25°C
0.031
glutathione disulfide
-
enzyme from unfrozen state, presence of urea plus glucose, pH 7.2, 25°C
0.0355
glutathione disulfide
-
at pH 7.5 and 50°C
0.037
glutathione disulfide
-
25°C, pH not specified in the publication
0.04
glutathione disulfide
-
0.045
glutathione disulfide
-
chloroquine-sensitive strain D10, pH 6.9, 25°C
0.0465
glutathione disulfide
-
crude enzyme, at pH 7.0 and 22°C
0.048
glutathione disulfide
-
enzyme from frozen state, pH 7.2, 25°C
0.05
glutathione disulfide
-
purified enzyme, at pH 7.0 and 22°C
0.0531
glutathione disulfide
-
in 100 mM potassium phosphate buffer, pH 7.4, 4 mM EDTA, at 37°C
0.054
glutathione disulfide
-
enzyme from unfrozen state, pH 7.2, 25°C
0.06
glutathione disulfide
-
at 30°C and pH 7.5
0.06202
glutathione disulfide
enzyme variant GR2, pH 7.6, 22°C
0.065
glutathione disulfide
-
-
0.065
glutathione disulfide
-
chloroquine-resistant strain FCR3, pH 6.9, 25°C
0.06896
glutathione disulfide
-
pH 7.5, 25°C
0.07
glutathione disulfide
-
pH 7.5, 22°C
0.071
glutathione disulfide
-
chloroquine-sensitive strain 3D7, pH 6.9, 25°C
0.072
glutathione disulfide
pH 7.4, 25°C
0.073
glutathione disulfide
-
chloroquine-sensitive strain S106, pH 6.9, 25°C
0.074
glutathione disulfide
-
chloroquine-resistant strain Dd2, pH 6.9, 25°C
0.076
glutathione disulfide
-
chloroquine-sensitive strain HB3, pH 6.9, 25°C
0.077
glutathione disulfide
-
in 100 mM K2HPO4/KH2PO4 buffer, at pH 7.4
0.08
glutathione disulfide
-
chloroquine-resistant strain 7G8, pH 6.9, 25°C
0.085
glutathione disulfide
-
enzyme from unfrozen state, presence of urea, pH 7.2, 25°C
0.088
glutathione disulfide
-
chloroquine-resistant strain K1, pH 6.9, 25°C
0.089
glutathione disulfide
CDJ91018
pH 7.8, 37°C
0.095
glutathione disulfide
-
pH 7.4, 25°C
0.1
glutathione disulfide
pH 7.5, 37°C
0.114
glutathione disulfide
-
in 100 mM potassium phosphate buffer (pH 8.0), at 25°C
0.1538
glutathione disulfide
pH 8.0, temperature not specified in the publication
0.154
glutathione disulfide
-
pH 7.4, 37°C
0.59
glutathione disulfide
-
in 50 mM potassium phosphate buffer pH 7.0, at 37°C
1.65
glutathione disulfide
mutant enzyme, pH 7.4, 25°C
2.31
glutathione disulfide
-
mutant enzyme, pH 7.4, 25°C
0.00446
GSSG
-
anoxic enzyme in 50 mM potassium phosphate, pH 7.4, 1 mM EDTA, 0.1 mM GSSG and 0.2 mM NADPH
0.019
GSSG
-
0.03 M phosphate buffer
0.028
GSSG
-
chloroplast enzyme
0.04
GSSG
-
chloroplast enzyme
0.05
GSSG
-
isozmes GR-1 and GR-2
0.056
GSSG
-
isozyme GR-1H
0.061
GSSG
-
pH 7.5, wild-type enzyme
0.0715
GSSG
-
truncated recombinant enzyme (lacking the last two amino acids Sec597-Gly598), in 150 mM potassium phosphate pH 7.0, at 37°C
0.073
GSSG
-
isozyme GR-1NH
0.097
GSSG
-
pH 7.5, mutant enzyme N21R
0.12
GSSG
-
pH 7.5, mutant enzyme N101D/K105D
0.125
GSSG
-
0.3 M phosphate buffer
0.131
GSSG
-
isozyme GR-2NH
0.139
GSSG
-
isozyme GR-2H
0.16
GSSG
-
recombinant enzyme
0.205
GSSG
-
full length enzyme, in 150 mM potassium phosphate pH 7.0, at 37°C
0.2625
GSSG
recombinant Glr1
0.0312
menadione
-
25°C
0.017
NADH
-
-
1.12
NADH
-
recombinant enzyme
0.03
NADP+
-
purified enzyme at pH 7.0 and 22°C
0.048
NADP+
-
crude enzyme, at pH 7.0 and 22°C
0.22
NADP+
-
root and chloroplast enzyme
0.0015
NADPH
-
-
0.0023
NADPH
-
root enzyme
0.003
NADPH
-
pH 7.8, 25°C
0.003
NADPH
-
chloroplast enzyme
0.003
NADPH
-
chloroplast enzyme
0.0037
NADPH
-
in 50 mM potassium phosphate buffer (pH 7.0)
0.004
NADPH
-
erythrocyte enzyme, pH 7.0, 30°C
0.0045
NADPH
-
4°C, pH not specified in the publication
0.0047
NADPH
-
in 50 mM potassium phosphate buffer (pH 7.0)
0.005
NADPH
-
liver enzyme, pH 7.0, 30°C
0.00601
NADPH
enzyme variant GR2, pH 7.6, 22°C
0.00682
NADPH
-
anoxic enzyme in 50 mM potassium phosphate, pH 7.4, 1 mM EDTA, 0.1 mM GSSG and 0.2 mM NADPH
0.007
NADPH
-
isozyme GR-1
0.00706
NADPH
-
at pH 7.5 and 50°C
0.008
NADPH
-
liver enzyme
0.008
NADPH
-
brain enzyme, pH 7.0, 30°C
0.009
NADPH
-
liver enzyme
0.009
NADPH
-
erythrocyte enzyme
0.0095
NADPH
-
0.03 M phosphate buffer
0.0109
NADPH
-
25°C, pH not specified in the publication
0.012
NADPH
-
25°C, pH not specified in the publication
0.013
NADPH
-
0.3 M phosphate buffer
0.014
NADPH
-
at 30°C and pH 7.5
0.015
NADPH
-
chloroplast enzyme
0.0153
NADPH
-
in 100 mM potassium phosphate buffer, pH 7.4, 4 mM EDTA, at 37°C
0.01695
NADPH
-
pH 7.5, 25°C
0.019
NADPH
-
crude enzyme, at pH 7.0 and 22°C
0.021
NADPH
-
calf liver enzyme, pH 7.0, 30°C
0.021
NADPH
-
purified enzyme, at pH 7.0 and 22°C
0.02662
NADPH
enzyme variant GR1.2, pH 7.6, 22°C
0.028
NADPH
-
isozyme GR-2
0.0323
NADPH
recombinant Glr1
0.033
NADPH
-
in 100 mM K2HPO4/KH2PO4 buffer, at pH 7.4
0.03843
NADPH
enzyme variant GR1.1, pH 7.6, 22°C
0.056
NADPH
-
in 100 mM potassium phosphate buffer (pH 8.0), at 25°C
0.061
NADPH
-
brain enzyme
0.063
NADPH
-
pH 7.4, 37°C
0.1449
NADPH
pH 8.0, temperature not specified in the publication
0.24
NADPH
-
recombinant enzyme
0.27
NADPH
-
in 50 mM potassium phosphate buffer pH 7.0, at 37°C
0.234
quinoline-5,8-dione
-
25°C
0.363
quinoline-5,8-dione
-
25°C
0.0562
quinoxaline-5,8-dione
-
25°C
0.0595
quinoxaline-5,8-dione
-
25°C
0.21
trypanothione
-
pH 7.5, mutant enzyme A18E/N21W/R22N/N101D/K105D/R319A
0.33
trypanothione
-
pH 7.5, mutant enzyme A18E/N21W/R22N/N101D/K105D
0.5
trypanothione
recombinant glutathione-trypanothione reductase-like enzyme
0.66
trypanothione
-
pH 7.5, mutant enzyme A18E/N21W/R22N
2
trypanothione
-
pH 7.5, wild-type enzyme
2.3
trypanothione
-
pH 7.5, mutant enzyme N101D/K105D
4.58
trypanothione
-
pH 7.5, mutant enzyme N21R
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
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-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
thermal dependency of Km
-
additional information
additional information
-
thermal dependency of Km
-
additional information
additional information
-
different isozymes, temperature-dependent, homo-glutathione
-
additional information
additional information
-
Km of wild-type and mutants
-
additional information
additional information
-
kinetics, hysteretic behaviour
-