1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)
This is an abbreviated version!
For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.
Word Map on EC 1.8.1.5
-
1.8.1.5
-
propylene
-
thioether
-
co2
-
acetone
-
xanthobacter
-
flavin
-
2-bromoethanesulfonate
-
dyad
-
co2-fixing
-
fad-containing
-
epoxypropane
-
epoxide
-
autotrophicus
-
phe-his
-
pka
-
electrophile
-
thioredoxins
-
his-glu
-
interchange
-
encapsulate
-
air-oxidized
- 1.8.1.5
- propylene
- thioether
- co2
- acetone
- xanthobacter
- flavin
- 2-bromoethanesulfonate
-
dyad
-
co2-fixing
-
fad-containing
- epoxypropane
- epoxide
- autotrophicus
-
phe-his
- pka
-
electrophile
- thioredoxins
- his-glu
-
interchange
-
encapsulate
-
air-oxidized
Reaction
Synonyms
2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC
ECTree
1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + NADPH + H+
acetone + 2-mercaptoethanesulfonate + NADP+
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-oxopropyl-coenzyme M + CO2 + NADPH
coenzyme M + acetoacetate + NADP+
-
-
-
?
3-mercaptopropanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
3-mercaptopropionate + acetoacetate + NADP+
3-(2-oxopropylthio)propionate + CO2 + NADPH + H+
-
poor cofactor, 11% of activity
-
?
CO2 + acetoacetate
acetoacetate + CO2
-
exchange of C-14 without added cofactors
-
?
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
?
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH
2-mercaptoethanesulfonate + acetoacetate + NADP+
terminal enzyme in the metabolic pathway converting propylene to acetoacetate
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH
2-mercaptoethanesulfonate + acetoacetate + NADP+
i.e. 2-ketopropyl-CoM, comparison of enzyme structure with and without bound substrate, binding of 2-ketopropyl-coenzyme M induces a conformational change resulting in collapse of the substrate access channel, substrate binding site structure analysis
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
?
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
r
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+
-
-
-
r
2-(2-oxopropylthio)ethanesulfonate + NADPH + H+
acetone + 2-mercaptoethanesulfonate + NADP+
-
-
-
ir
2-(2-oxopropylthio)ethanesulfonate + NADPH + H+
acetone + 2-mercaptoethanesulfonate + NADP+
-
-
-
ir
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
-
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
-
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
dual function enzyme, reverse reaction of component II of carboxylation pathway
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
involved in epoxide carboxylation pathway in bacteria, reverse reaction more important
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
involved in epoxide carboxylation pathway in bacteria, reverse reaction more important
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
dual function enzyme, reverse reaction of component II of carboxylation pathway
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
involved in epoxide carboxylation pathway in bacteria, reverse reaction more important
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
-
-
r
2-mercaptoethanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
involved in epoxide carboxylation pathway in bacteria, reverse reaction more important
-
r
3-mercaptopropanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
very poor cofactor, 1% of activity
-
?
3-mercaptopropanesulfonate + acetoacetate + NADP+
2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
very poor cofactor, 1% of activity
-
?
