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(R,S)-lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
-
r
1,4-benzoquinone + NADH
1,4-benzoquinol + NAD+
1-methoxyphenazinium methosulfate + NADH
? + NAD+
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
-
cytochrome c is a poor electron acceptor, only in presence of methylene blue the enzyme shows some activity
-
-
?
2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
2,6-dimethoxy-1,4-benzoquinone + NADH
? + NAD+
8.0% activity compared to lipoamide
-
-
?
2,6-dimethyl-1,4-benzoquinone + NADH
2,6-dimethyl-1,4-benzoquinol + NAD+
2-(p-iodophenyl)-3-p-nitrophenyl-5-phenyltetrazolium chloride + NADH
? + NAD+
2-hydroxy-1,4-benzoquinone + NADH
2-hydroxy-1,4-benzoquinol + NAD+
-
-
-
-
?
2-methyl-1,4-benzoquinone + NADH
2-methyl-1,4-benzoquinol + NAD+
-
-
-
-
?
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide + NADH
?
3-nitrotyrosine + dihydrolipoic acid
3-aminotyrosine + lipoic acid + H2O
3-nitrotyrosine + NAD(P)H
3-aminotyrosine + NAD(P)+ + H2O
-
-
-
-
?
3-nitrotyrosine + NADPH
3-aminotyrosine + NADP+ + H2O
-
-
-
-
?
3-nitrotyrosine + ubiquinol
3-aminotyrosine + ubiquinone + H2O
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
5-hydroxy-1,4-naphthoquinone + NADH
5-hydroxy-1,4-naphthoquinol + NAD+
-
-
-
-
?
5-nitroblue tetrazolium chloride + NADH
? + NAD+
-
5.1% of the activity with lipoamide
-
-
?
8-nitroguanine + dihydrolipoic acid
8-aminoguanine + lipoic acid + H2O
8-nitroguanine + NAD(P)H
8-aminoguanine + NAD(P)+ + H2O
-
-
-
-
?
8-nitroguanine + NADPH
8-aminoguanine + NADP+ + H2O
-
-
-
-
?
8-nitroguanine + ubiquinol
8-aminoguanine + ubiquinone + H2O
8-nitroxanthine + dihydrolipoic acid
8-aminoxanthine + lipoic acid + H2O
8-nitroxanthine + NAD(P)H
8-aminoxanthine + NAD(P)+ + H2O
-
-
-
-
?
8-nitroxanthine + NADPH
8-aminoxanthine + NADP+ + H2O
-
-
-
-
?
8-nitroxanthine + ubiquinol
8-aminoxanthine + ubiquinone + H2O
alpha-lipoamide + NADH
dihydrolipoamide + NAD+
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
benzyl viologen + NADH
? + NAD+
-
2.9% of the activity with lipoamide
-
-
?
coenzyme Q-10 + NADPH
ubiquinol + NADP+
dihydrolipoamide + NAD+
lipoamide + NADH
dihydrolipoamide + NAD+
lipoamide + NADH + H+
dihydrolipoamide + NADP+
lipoamide + NADPH
-
-
-
r
dihydrolipoate + NAD+
lipoate + NADH + H+
-
-
-
-
r
dihydrolipoic acid + NAD+
lipoic acid + NADH + H+
-
-
-
?
DL-6,8-thiooctic acid amide + NADH
? + NAD+
-
-
-
-
r
DL-alpha-lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
?
DL-lipoamide + NADH
DL-dihydrolipoamide + NAD+
DL-lipoamide + NADH + H+
DL-dihydrolipoamide + NAD+
DL-lipoate + NADH
? + NAD+
-
-
-
-
?
DL-lipoylbutanoate + NADH
? + NAD+
-
-
-
-
?
DL-lipoylpentanoate + NADH
? + NAD+
-
100fold reaction by the enzyme in two-electron-reduced state compared to the enzyme in four-electron-reduced state
-
-
?
ferrileghemoglobin + NADH + H+
ferroleghemoglobin + NAD+
-
-
-
r
ferrocene + NADH
? + NAD+
3.6% activity compared to lipoamide
-
-
?
ferrocenecarboxylic acid + NADH
? + NAD+
4.1% activity compared to lipoamide
-
-
?
glycerol trinitrate + NADH
?
hexacyanoferrate + NADH
? + NAD+
-
-
-
-
?
hydroxylamine hydrochloride + NADH
?
iodonitrotetrazolium + NADH
? + NAD+
-
-
-
-
?
iodonitrotetrazolium chloride + NADH
? + NAD+
19.3% activity compared to lipoamide
-
-
?
lipoamide + 3-acetylpyridine adenine dinucleotide
dihydrolipoamide + ?
-
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
lipoamide + NADH + H+
dihydrolipoamide + NAD+
lipoamide + nicotinamide hypoxanthine dinucleotide
dihydrolipoamide + ?
-
-
-
-
?
lipoamide + thio-NADH
dihydrolipoamide + thio-NAD+
-
-
-
-
?
lipoate + NADH + H+
dihydrolipoate + NAD+
-
-
-
-
r
lipoic acid + NADH
dihydrolipoic acid + NAD+
lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
lipoyl H-protein + NADH + H+
dihydrolipoyl H-protein + NAD+
-
-
-
-
r
mature frataxin + NADH
denoted frataxin + NAD+
menadione + NADH
? + NAD+
methylene blue + NADH
? + NAD+
methylene blue + NADH + H+
reduced methylene blue + NAD+
metmyoglobin + NADH
reduced myoglobin + NAD+
-
myoglobin is a poor electron acceptor, only in presence of methylene blue the enzyme shows some activity
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
naphthoquinone + NADH
1,4-naphthoquinol + NAD+
nitrated DNA + NAD(P)H
?
-
enzyme reduces DNA nitro adducts including 8-nitroguanine, 3-nitrotyrosine, and 8-nitroxanthine, which formed in presence of peroxynitrite and nitryl chloride present in inflamed tissues, the nitrated DNA adducts are unstable and undergo spontaneous depurination which can cause cancer, enzyme might be resonsible for reversing biological nitration processes
-
-
?
nitrated DNA + NADPH
DNA + NADP+ + H2O
-
enzyme reduces DNA nitro adducts including 8-nitroguanine, 3-nitrotyrosine, and 8-nitroxanthine, which formed in presence of peroxynitrite and nitryl chloride present in inflamed tissues, the nitrated DNA adducts are unstable and undergo spontaneous depurination
-
-
?
nitric oxide + NADH
nitrate + NAD+
-
-
-
-
?
nitro blue tetrazolium + NADH
? + NAD+
nitrotetrazolium blue + NADH
? + NAD+
2.9% activity compared to lipoamide
-
-
?
nitrotetrazolium blue + NADH + H+
reduced nitrotetrazolium blue + NAD+
-
-
-
-
r
O2 + NADH + H+
H2O2 + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
oxidized lipoamide + NADH
reduced lipoamide + NAD+
-
-
-
-
?
oxidized lipoic acid + NADH
reduced lipoic acid + NAD+
-
-
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
protein N6-(dihydrolipoyl)lysine + NAD+
protein N6-(lipoyl)lysine + NADH + H+
-
-
-
-
?
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
pyocyanin + NADH + H+
reduced pyocyanin + NAD+
pyocyanin is reported to stimulate respiration
-
-
?
pyruvate + NADH
?
-
-
-
-
?
reduced DL-lipoamide + NAD+
oxidized DL-lipoamide + NADH
-
-
-
-
r
reduced lipoamide + NAD+
oxidized lipoamide + NADH
resazurin + NADH
? + NAD+
155.8% activity compared to lipoamide
-
-
?
resorufin + NADH
? + NAD+
19.1% activity compared to lipoamide
-
-
?
S-nitroso-N-acetylpenicillamine + NADH
?
S-nitrosoglutathione + NADH
?
sodium nitroprusside + NADH
?
sulfonated tetrazolium WST-1 + NADH
formazan derivative + NAD+
39.2% activity compared to lipoamide
-
-
?
tellurite + NADH
NAD+ + ?
thio-NAD+ + NADH
thio-NADH + NAD+
ubiquinone + NAD(P)H
ubiquinol + NAD(P)+
ubiquinone-10 + NAD(P)H
ubiquinol-10 + NAD(P)+
vitamin K5 + NADH
?
-
-
-
-
?
additional information
?
-
1,4-benzoquinone + NADH
1,4-benzoquinol + NAD+
-
-
-
-
?
1,4-benzoquinone + NADH
1,4-benzoquinol + NAD+
-
-
-
-
?
1-methoxyphenazinium methosulfate + NADH
? + NAD+
248.1% activity compared to lipoamide
-
-
?
1-methoxyphenazinium methosulfate + NADH
? + NAD+
248.1% activity compared to lipoamide
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
activity with wild-type enzyme and mutant enzymes C44S and C49S
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
-
-
-
?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
31.1% of the activity with lipoamide
-
-
?
2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
-
-
-
-
r
2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
-
-
-
r
2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
-
-
-
-
r
2,6-dimethyl-1,4-benzoquinone + NADH
2,6-dimethyl-1,4-benzoquinol + NAD+
-
-
-
-
?
2,6-dimethyl-1,4-benzoquinone + NADH
2,6-dimethyl-1,4-benzoquinol + NAD+
-
90fold reaction by the enzyme in four-electron-reduced state compared to the enzyme in two-electron-reduced state
-
-
?
2-(p-iodophenyl)-3-p-nitrophenyl-5-phenyltetrazolium chloride + NADH
? + NAD+
-
-
-
?
2-(p-iodophenyl)-3-p-nitrophenyl-5-phenyltetrazolium chloride + NADH
? + NAD+
-
-
-
?
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide + NADH
?
-
-
-
-
?
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide + NADH
?
-
-
-
-
?
3-nitrotyrosine + dihydrolipoic acid
3-aminotyrosine + lipoic acid + H2O
-
-
-
-
?
3-nitrotyrosine + dihydrolipoic acid
3-aminotyrosine + lipoic acid + H2O
-
-
-
-
?
3-nitrotyrosine + ubiquinol
3-aminotyrosine + ubiquinone + H2O
-
-
-
-
?
3-nitrotyrosine + ubiquinol
3-aminotyrosine + ubiquinone + H2O
-
-
-
-
?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
-
-
-
-
?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
-
-
-
-
?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
-
-
-
?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
-
-
-
?
8-nitroguanine + dihydrolipoic acid
8-aminoguanine + lipoic acid + H2O
-
-
-
-
?
8-nitroguanine + dihydrolipoic acid
8-aminoguanine + lipoic acid + H2O
-
-
-
-
?
8-nitroguanine + ubiquinol
8-aminoguanine + ubiquinone + H2O
-
-
-
-
?
8-nitroguanine + ubiquinol
8-aminoguanine + ubiquinone + H2O
-
-
-
-
?
8-nitroxanthine + dihydrolipoic acid
8-aminoxanthine + lipoic acid + H2O
-
-
-
-
?
8-nitroxanthine + dihydrolipoic acid
8-aminoxanthine + lipoic acid + H2O
-
-
-
-
?
8-nitroxanthine + ubiquinol
8-aminoxanthine + ubiquinone + H2O
-
-
-
-
?
8-nitroxanthine + ubiquinol
8-aminoxanthine + ubiquinone + H2O
-
-
-
-
?
acetaldoxime + NADH
?
-
-
-
-
?
acetaldoxime + NADH
?
-
-
-
-
?
alpha-lipoamide + NADH
dihydrolipoamide + NAD+
Starkeyomyces koorchalomoides
-
-
-
-
?
alpha-lipoamide + NADH
dihydrolipoamide + NAD+
Starkeyomyces koorchalomoides FDUS 0337
-
-
-
-
?
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
-
?
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
-
?
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
?
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
?
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
-
?
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
-
?
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
?
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
?
coenzyme Q-10 + NADPH
ubiquinol + NADP+
-
-
-
-
?
coenzyme Q-10 + NADPH
ubiquinol + NADP+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
DLDH activity, forward reaction
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
Azotobacter agilis
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
mutant enzymes C44S and C49S show minute activity
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
regulation of activity dependent on tyrosine-phosphorylation of the enzyme
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
the forward reaction is the physiological one
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH
-
alternate oxidation and reduction of an intrachain disulfide bond
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
dihydrolipoamide dehydrogenase (LipDH) transfers two electrons from dihydrolipoamide to NAD+ mediated by FAD
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
r
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
?
dihydrolipoamide + NAD+
lipoamide + NADH + H+
-
-
-
-
r
DL-lipoamide + NADH
DL-dihydrolipoamide + NAD+
-
specific substrate
-
-
?
DL-lipoamide + NADH
DL-dihydrolipoamide + NAD+
-
specific substrate
-
-
?
DL-lipoamide + NADH + H+
DL-dihydrolipoamide + NAD+
-
-
-
-
?
DL-lipoamide + NADH + H+
DL-dihydrolipoamide + NAD+
-
-
-
-
?
formaldoxime + NADH
?
-
-
-
-
?
formaldoxime + NADH
?
-
-
-
-
?
glycerol trinitrate + NADH
?
-
-
-
-
?
glycerol trinitrate + NADH
?
-
-
-
-
?
hydroxylamine hydrochloride + NADH
?
-
-
-
-
?
hydroxylamine hydrochloride + NADH
?
-
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
NADH:lipoamide oxidoreductase activity, reverse reaction
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
100% activity
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
100% activity
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
r
lipoamide + NADH
dihydrolipoamide + NAD+
-
-
-
-
?
lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
?
lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
-
r
lipoamide + NADH + H+
dihydrolipoamide + NAD+
-
-
-
-
r
lipoic acid + NADH
dihydrolipoic acid + NAD+
-
-
-
-
?
lipoic acid + NADH
dihydrolipoic acid + NAD+
-
-
-
r
lipoic acid + NADH
dihydrolipoic acid + NAD+
-
-
-
-
?
lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
-
r
lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
-
-
-
-
r
mature frataxin + NADH
denoted frataxin + NAD+
-
cleavage by C-term DLD
-
-
?
mature frataxin + NADH
denoted frataxin + NAD+
-
cleavage by C-term DLD
-
-
?
mature frataxin + NADH
denoted frataxin + NAD+
-
exhibits DLD activity but is proteolytically inactive against mature frataxin. Purified pig DLD preparation exhibits weak but clear proteolytic activity
-
-
?
menadione + NADH
? + NAD+
2.9% activity compared to lipoamide
-
-
?
menadione + NADH
? + NAD+
2.9% activity compared to lipoamide
-
-
?
menadione + NADH
? + NAD+
-
13.6% of the activity with lipoamide
-
-
?
methylene blue + NADH
? + NAD+
-
-
-
-
?
methylene blue + NADH
? + NAD+
-
9.4% of the activity with lipoamide
-
-
?
methylene blue + NADH + H+
reduced methylene blue + NAD+
-
-
-
?
methylene blue + NADH + H+
reduced methylene blue + NAD+
-
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
naphthoquinone + NADH
1,4-naphthoquinol + NAD+
-
-
-
-
?
naphthoquinone + NADH
1,4-naphthoquinol + NAD+
-
-
-
-
?
nitro blue tetrazolium + NADH
? + NAD+
-
-
-
?
nitro blue tetrazolium + NADH
? + NAD+
-
-
-
-
?
nitro blue tetrazolium + NADH
? + NAD+
-
-
-
-
?
O2 + NADH
?
-
activity with wild-type enzyme and mutant enzymes C44S and C49S
-
-
?
O2 + NADH
H2O2 + NAD+
-
-
-
-
?
O2 + NADH
H2O2 + NAD+
-
40fold reaction by the enzyme in four-electron-reduced state compared to the enzyme in two-electron-reduced state
-
-
?
O2 + NADH
H2O2 + NAD+
-
-
-
-
?
O2 + NADH
H2O2 + NAD+
-
the enzyme produces reactive oxygen species, i.e. hydrogen peroxide, acting as an oxidase
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
activity with wild-type enzyme and mutant enzymes C44S and C49S
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
233.4% activity compared to lipoamide
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
233.4% activity compared to lipoamide
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
-
12.3% of the activity with lipoamide
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
by cell lysate
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
PCA, the precursor for all biological phenazines in Pseudomonas aeruginosa, promotes anaerobic energy generation by redox cycling. Enzyme LpdG residues Val191 and Ile192 do not sterically hinder PCA frombinding to LpdG
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
the precursor for all biological phenazines in Pseudomonas aeruginosa, promotes anaerobic energy generation by redox cycling
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
by cell lysate
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
PCA, the precursor for all biological phenazines in Pseudomonas aeruginosa, promotes anaerobic energy generation by redox cycling. Enzyme LpdG residues Val191 and Ile192 do not sterically hinder PCA frombinding to LpdG
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
the precursor for all biological phenazines in Pseudomonas aeruginosa, promotes anaerobic energy generation by redox cycling
-
-
?
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
-
-
-
r
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
-
-
-
r
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
-
-
-
-
r
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
-
-
-
-
r
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
-
-
-
r
reduced lipoamide + NAD+
oxidized lipoamide + NADH
-
-
-
-
r
reduced lipoamide + NAD+
oxidized lipoamide + NADH
-
enzyme catalyzes the NAD+-dependent oxidation of dihydrolipoyl cofactors being covalently attached to the acyltransferase components of pyruvate dehydrogenase, 2-ketoglutarate dehydrogenase, and glycine reductase multienzyme complexes
-
-
r
S-nitroso-N-acetylpenicillamine + NADH
?
-
-
-
-
?
S-nitroso-N-acetylpenicillamine + NADH
?
-
-
-
-
?
S-nitrosoglutathione + NADH
?
-
-
-
-
?
S-nitrosoglutathione + NADH
?
-
-
-
-
?
sodium nitroprusside + NADH
?
-
-
-
-
?
sodium nitroprusside + NADH
?
-
-
-
-
?
tellurite + NADH
NAD+ + ?
-
-
-
-
?
tellurite + NADH
NAD+ + ?
-
-
-
-
?
tellurite + NADH
NAD+ + ?
-
-
-
?
tellurite + NADH
NAD+ + ?
-
-
-
?
tellurite + NADH
NAD+ + ?
-
-
-
?
thio-NAD+ + NADH
thio-NADH + NAD+
-
-
-
-
?
thio-NAD+ + NADH
thio-NADH + NAD+
-
activity with wild-type enzyme and mutant enzymes C44S and C49S
-
-
?
thio-NAD+ + NADH
thio-NADH + NAD+
-
-
-
-
?
ubiquinone + NAD(P)H
ubiquinol + NAD(P)+
-
-
-
-
?
ubiquinone + NAD(P)H
ubiquinol + NAD(P)+
-
-
-
-
ir
ubiquinone + NAD(P)H
ubiquinol + NAD(P)+
-
enzyme is involved in extramitochondrial regeneration of the important antioxidant ubiquinol required for cell protection against peroxidation
-
-
?
ubiquinone-10 + NAD(P)H
ubiquinol-10 + NAD(P)+
-
-
-
-
?
ubiquinone-10 + NAD(P)H
ubiquinol-10 + NAD(P)+
-
reaction is important to protect the cell e.g. from oxidative stress
-
-
?
additional information
?
-
-
NADH:NAD+ transhydrogenase activity
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
LAD is unable to convert formamidoxim, acetone oxime, acetohydroxamic acid, and Nomega-hydroxy-L-arginine
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
the enzyme is an essential component of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes
-
-
?
additional information
?
-
-
the enzyme is an essential component of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes
-
-
?
additional information
?
-
the enzyme is an essential component of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the most important function of dehydrolipoamide dehydrogenase as a component of the pyruvate dehydrogenase and the 2-oxoglutarate dehydrogenase complex is the implication in the oxidative decarboxylation of pyruvate and 2-oxoglutarate
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is one of the major antigens for production of autoantibodies after infection with hepatitis C virus causing autoimmune phenomena like higher prevalences for liver cirrhosis, arthritis, abnormal liver function, and elevated alpha-FP levels, immunocolorimetrical determination of anti-E3 antibody titer after infection in several patients and of clinical manifestations, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the reoxidation of the covalently bound reduced lipoic acid cofactor of the E2 subunits of all the mitochondrial alpha-keto acid dehydrogenase multienzyme complexes including the alpha-ketoglutarate dehydrogenase complex, the pyruvate dehydrogenase complex, and the branched-chain alpha-keto acid dehydrogenase complex
-
-
-
additional information
?
-
-
the enzyme also shows diaphorase activity with 2,6-dichlorophenol indophenol and thiazolyl blue tetrazolium bromide
-
-
-
additional information
?
-
-
the enzyme also shows diaphorase activity with 2,6-dichlorophenol indophenol and thiazolyl blue tetrazolium bromide
-
-
-
additional information
?
-
-
DLD catalyzes the reduction of NAD+ by dihydrolipoamide and exhibits NADH-dependent diaphorase activity
-
-
?
additional information
?
-
-
DLD catalyzes the reduction of NAD+ by dihydrolipoamide and exhibits NADH-dependent diaphorase activity
-
-
?
additional information
?
-
-
diaphorase activity
-
-
?
additional information
?
-
enzyme is involved in capacitation of spermatozoa in hamster, enzyme regulation in spermatozoa via tyrosine-phosphorylation, overview
-
-
?
additional information
?
-
-
the enzyme is required for hyperactivation, i.e. enhanced motility, and acrosome reaction of hamster spermatozoa, the post-pyruvate metabolic enzyme shows dual involvement and regulation during sperm capacitation, control of the directionality of enzyme activity during sperm capacitation
-
-
?
additional information
?
-
no activity with NADPH, potassium ferricyanide and methylene blue
-
-
?
additional information
?
-
-
no activity with NADPH, potassium ferricyanide and methylene blue
-
-
?
additional information
?
-
no activity with NADPH, potassium ferricyanide and methylene blue
-
-
?
additional information
?
-
-
reductive half-reaction, hydride transfer from NADH to FAD, is rate limiting when a quinone is the oxidant
-
-
?
additional information
?
-
-
EC 1.8.1.4 is the E3-protein component of the mitochondrial 2-oxoacid dehydrogenase multienzyme complexes and the L-protein component of the glycine decarboxylase system
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the physiological substrates are the dihydrolipoyl domain of the E2 component, dihydrolipoyl acyltransferase, of the 2-oxoacid dehydrogenase multienzyme complexs or the dihydrolipoyl H-protein of the mitochobdrial glycine decarboxylase
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
phenazines may substitute for NAD+ in LpdG and other enzymes, achieving the same end by a different mechanism. PCA and pyocyanin reduction by the purified complexes required all substrates and cofactors
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
LPD-Val is specifically required as the lipoamide dehydrogenase of branched-chain keto acid dehydrogenase, LPD-Glc fulfills all other requirements for lipoamide dehydrogenase
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
enzyme lacks diaphorase activity
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
lack of dihydrolipoamide dehydrogenase results in a deficiency in alpha-galactoside metabolism and galactose transport
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
diaphorase activity
-
-
?
additional information
?
-
-
the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids
-
-
?
additional information
?
-
-
the enzyme might play a role in modifying NO levels under specific cell conditions
-
-
?
additional information
?
-
-
LAD is unable to convert formamidoxim, acetone oxime, acetohydroxamic acid, and Nomega-hydroxy-L-arginine
-
-
?
additional information
?
-
-
the enzyme fulfills its function in the pyruvate, 2-oxoglutarate and branched-chain 2-oxoacid dehydrogenase complexes and in the glycine cleavage system
-
-
?