1.8.1.19: sulfide dehydrogenase
This is an abbreviated version!
For detailed information about sulfide dehydrogenase, go to the full flat file.
Word Map on EC 1.8.1.19
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1.8.1.19
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sulfur
-
thiosulfate
-
phototrophic
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flavocytochrome
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sulfide-quinone
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sulfur-oxidizing
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furiosus
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chromatium
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wolinella
-
vinosum
-
succinogenes
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sulfide-dependent
- 1.8.1.19
- sulfur
- thiosulfate
-
phototrophic
-
flavocytochrome
-
sulfide-quinone
-
sulfur-oxidizing
- furiosus
- chromatium
-
wolinella
- vinosum
- succinogenes
-
sulfide-dependent
Reaction
Synonyms
PF1328, SuDH, SuDH I
ECTree
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Cofactor
Cofactor on EC 1.8.1.19 - sulfide dehydrogenase
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FAD
both the alpha-subunit and the beta-subunit contains one FAD
the alpha-subunit carries a [2Fe-2S]2+,+ prosthetic group. It exhibits EPR g-values, 2.035, 1.908, 1.786, and reduction potential, Em,8 = +80 mV, reminiscent of Rieske-type clusters. Comparative sequence analysis indicates that this cluster is coordinated by a novel motif of one Asp and three Cys ligands. The beta-subunit carries a [3Fe-4S]+,0 cluster, and a [4Fe-4S]2+,+ cluster. The 3Fe cluster has an unusually high reduction potential, Em,8 = +230 mV. The reduced 4Fe cluster exhibits a complex EPR signal, presumably resulting from magnetic interaction of its S = 1/2 spin with the S=2 spin of the reduced 3Fe cluster. The 4Fe cluster can be reduced with deazaflavin/EDTA/light but not with sodium dithionite, however, it is readily reduced with NADPH
Fe-S center
the enzyme contains approximately four iron-sulfur centers, 11 iron and 6 acid-labile sulfide atoms per mol
both the alpha-subunit and the beta-subunit carry one putative nucleotide binding site for NADPH
NADPH
NADH was not utilized as an electron donor for polysulfide reduction