1.7.3.3: factor-independent urate hydroxylase

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For detailed information about factor-independent urate hydroxylase, go to the full flat file.

Word Map on EC 1.7.3.3

1.7.3.3

hyperuricemia

peroxisomal

xanthine

allopurinol

gout

purine

catalase

allantoin

biosensors

electrode

hematologic

creatinine

oxonic

febuxostat

allantoinase

hyperkalemia

hypoxanthine

prophylaxis

flavus

hyperphosphatemia

urate-lowering

ureide

methemoglobinemia

pegylated

amperometric

uricosuric

hypocalcemia

tophi

benzbromarone

hominoid

phosphotungstate

microbodies

hypouricemic

probenecid

utilis

pimecrolimus

pharmacology

medicine

analysis

synthesis

weight-based

nodule-specific

miocene

drug development

Reaction

Synonyms

AaUO, AgUOX, dHU-wPU, ELITEK, Fasturtec, MVSM, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Pucl, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme

ECTree

1 Oxidoreductases

1.7 Acting on other nitrogenous compounds as donors

1.7.3 With oxygen as acceptor

1.7.3.3 factor-independent urate hydroxylase

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Results	in table
12	Activating Compound
6578	AA Sequence
36	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Cofactor
18	Crystallization (Commentary)
2480	Disease/ Diagnostics
12	Expression
1	General Information
34	General Stability
227	Inhibitors
16	kcat/KM [mM/s]
15	Ki Value [mM]
73	KM Value [mM]
39	Localization
41	Metals/Ions
72	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
185	Organism
1	Oxidation Stability
7	Pathway
218	PDB ID
45	pH Optimum
19	pH Range
19	pH Stability
8	pI Value
49	Protein Variants
55	Purification (Commentary)
3	Reaction
11	Reaction Type
182	Reference
74	Source Tissue
91	Specific Activity [micromol/min/mg]
18	Storage Stability
160	Substrates and Products (Substrate)
61	Subunits
117	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
11	Temperature Range [°C]
37	Temperature Stability [°C]
20	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.7.3.3 - factor-independent urate hydroxylase

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urate:oxygen oxidoreductase

This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).