1.7.3.3: factor-independent urate hydroxylase
This is an abbreviated version!
For detailed information about factor-independent urate hydroxylase, go to the full flat file.
Word Map on EC 1.7.3.3
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1.7.3.3
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hyperuricemia
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peroxisomal
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xanthine
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allopurinol
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gout
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purine
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catalase
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allantoin
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biosensors
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electrode
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hematologic
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creatinine
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oxonic
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febuxostat
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allantoinase
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hyperkalemia
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hypoxanthine
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prophylaxis
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flavus
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hyperphosphatemia
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urate-lowering
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ureide
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methemoglobinemia
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pegylated
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amperometric
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uricosuric
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hypocalcemia
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tophi
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benzbromarone
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hominoid
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phosphotungstate
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microbodies
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hypouricemic
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probenecid
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utilis
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pimecrolimus
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pharmacology
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medicine
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analysis
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synthesis
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weight-based
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nodule-specific
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miocene
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drug development
- 1.7.3.3
- hyperuricemia
- peroxisomal
- xanthine
- allopurinol
- gout
- purine
- catalase
- allantoin
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biosensors
-
electrode
-
hematologic
- creatinine
-
oxonic
- febuxostat
- allantoinase
- hyperkalemia
- hypoxanthine
-
prophylaxis
- flavus
- hyperphosphatemia
-
urate-lowering
-
ureide
- methemoglobinemia
-
pegylated
-
amperometric
-
uricosuric
-
hypocalcemia
-
tophi
- benzbromarone
-
hominoid
-
phosphotungstate
- microbodies
-
hypouricemic
- probenecid
- utilis
- pimecrolimus
- pharmacology
- medicine
- analysis
- synthesis
-
weight-based
-
nodule-specific
-
miocene
- drug development
Reaction
Synonyms
AaUO, AgUOX, dHU-wPU, ELITEK, Fasturtec, MVSM, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Pucl, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme
ECTree
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Substrates Products
Substrates Products on EC 1.7.3.3 - factor-independent urate hydroxylase
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REACTION DIAGRAM
uric acid + O2 + H2O
5-hydroxyisourate + H2O2
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purine degradation
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urate + O2 + H2O
5-hydroxyisourate + H2O2
ureide pathway
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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enzyme production is induced by addition of uric acid to the culture medium
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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enzyme production is induced by addition of uric acid to the culture medium
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
first step in uric acid degradation
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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purine metabolism
a metastable intermediate, which is further degrades to allantoin
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
urate oxidase catalyzes the hydroxylation of uric acid into the metastable product 5-hydroxyisourate in the presence of molecular oxygen as part of the purine degradation pathway. 5-Hydroxyisourate decays slowly to allantoin, a process independent of oxygen and associated with the release of CO
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
dioxygen-binding site structure, overview
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urate + O2 + H2O
5-hydroxyisourate + H2O2
substrate binding involves residues Arg176 and Glu228, that hold the substrate, Phe159 closing one end of the cavity below, and the two residues Asn254 and Thr57, forming another tweezers above the mean plane of the ligand that construct a location where efficient electron transfer can take place at a low energy level via the catalytic triad Thr57, Lys10, and His256
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urate + O2 + H2O
5-hydroxyisourate + H2O2
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it is proposed that T69 and K9 form a catalytic diad in which K9 deprotonates T69 to allow it to abstract the proton from the N9 position of the substrate to generate the dianion
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
DQ887577
ureide pathway
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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detection of two discrete enzyme-bound intermediates by single-turnover stopped-flow techniques
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urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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conversion to allantoin
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
JX083378
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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anion-pi interactions are present in the active site of the enzyme and are energetically favorable
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additional information
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enzyme catalyzes the oxidation of uric acid to a more soluble and easily excreted compound, allantoin
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additional information
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purine degradation, urate oxidase catalyzes the oxidation of uric acid with poor solubility to produce 5-hydroxyisourate and allantoin
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additional information
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uricase can function as a voltage-sensitive channel that is highly selective to urate, relative to K+ and Cl-
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additional information
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rasburicase acts at the end of the purine catabolic pathway, and unlike allopurinol, it does not induce accumulation of xanthine or hypoxanthine
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additional information
?
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uricase can function as a voltage-sensitive channel that is highly selective to urate, relative to K+ and Cl-
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?