1.7.3.3: factor-independent urate hydroxylase
This is an abbreviated version!
For detailed information about factor-independent urate hydroxylase, go to the full flat file.
Word Map on EC 1.7.3.3
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1.7.3.3
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hyperuricemia
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peroxisomal
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xanthine
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allopurinol
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gout
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purine
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catalase
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allantoin
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biosensors
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electrode
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hematologic
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creatinine
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oxonic
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febuxostat
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allantoinase
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hyperkalemia
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hypoxanthine
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prophylaxis
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flavus
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hyperphosphatemia
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urate-lowering
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ureide
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methemoglobinemia
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pegylated
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amperometric
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uricosuric
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hypocalcemia
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tophi
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benzbromarone
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hominoid
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phosphotungstate
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microbodies
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hypouricemic
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probenecid
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utilis
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pimecrolimus
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pharmacology
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medicine
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analysis
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synthesis
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weight-based
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nodule-specific
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miocene
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drug development
- 1.7.3.3
- hyperuricemia
- peroxisomal
- xanthine
- allopurinol
- gout
- purine
- catalase
- allantoin
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biosensors
-
electrode
-
hematologic
- creatinine
-
oxonic
- febuxostat
- allantoinase
- hyperkalemia
- hypoxanthine
-
prophylaxis
- flavus
- hyperphosphatemia
-
urate-lowering
-
ureide
- methemoglobinemia
-
pegylated
-
amperometric
-
uricosuric
-
hypocalcemia
-
tophi
- benzbromarone
-
hominoid
-
phosphotungstate
- microbodies
-
hypouricemic
- probenecid
- utilis
- pimecrolimus
- pharmacology
- medicine
- analysis
- synthesis
-
weight-based
-
nodule-specific
-
miocene
- drug development
Reaction
Synonyms
AaUO, AgUOX, dHU-wPU, ELITEK, Fasturtec, MVSM, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Pucl, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.7.3.3 - factor-independent urate hydroxylase
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REACTION DIAGRAM
uric acid + O2 + H2O
5-hydroxyisourate + H2O2
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purine degradation
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urate + O2 + H2O
5-hydroxyisourate + H2O2
ureide pathway
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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enzyme production is induced by addition of uric acid to the culture medium
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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enzyme production is induced by addition of uric acid to the culture medium
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
first step in uric acid degradation
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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purine metabolism
a metastable intermediate, which is further degrades to allantoin
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
urate oxidase catalyzes the hydroxylation of uric acid into the metastable product 5-hydroxyisourate in the presence of molecular oxygen as part of the purine degradation pathway. 5-Hydroxyisourate decays slowly to allantoin, a process independent of oxygen and associated with the release of CO
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
DQ887577
ureide pathway
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-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
-
-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
-
-
?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
conversion to allantoin
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?
urate + O2 + H2O
5-hydroxyisourate + H2O2
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-
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?
?
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enzyme catalyzes the oxidation of uric acid to a more soluble and easily excreted compound, allantoin
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additional information
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purine degradation, urate oxidase catalyzes the oxidation of uric acid with poor solubility to produce 5-hydroxyisourate and allantoin
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additional information
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rasburicase acts at the end of the purine catabolic pathway, and unlike allopurinol, it does not induce accumulation of xanthine or hypoxanthine
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