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1.7.2.8: hydrazine dehydrogenase

This is an abbreviated version!
For detailed information about hydrazine dehydrogenase, go to the full flat file.

Word Map on EC 1.7.2.8

Reaction

hydrazine
+ 4 ferricytochrome c =
N2
+ 4 ferrocytochrome c

Synonyms

EC 1.7.99.8, HAO, HAOr-DH, HDH, hydrazine oxidoreductase, hydrazine-oxidizing enzyme, hydroxylamine oxidoreductase, hzoB

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.2 With a cytochrome as acceptor
                1.7.2.8 hydrazine dehydrogenase

Inhibitors

Inhibitors on EC 1.7.2.8 - hydrazine dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyanide
-
addition of 0.035 mM, 0.085 mM, or 0.35 mM cyanide results in 25%, 50%, and 95% inhibition, respectively
H2O2
-
0.0004 mM, 0.004 mM, and 0.04 mM results in a loss of activity of 30%, 75%, and 90%, respectively
hydrazine
-
competes strongly with hydroxylamine. Addition of 0.015 mM, 0.035 mM, and 0.35 mM results in 15%, 50%, and 85% inhibition, respectively
hydroxylamine
nitric oxide
-
strong competitive inhibitor
SDS
-
activity in the presence of 0.75%, 3%, and 8% SDS is reduced by 20%, 50%, and 95%, respectively
additional information
-
sodium azide, methanol, sodium nitrite, and the chelating agent EDTA do not inhibit enzyme activity
-