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1.7.1.7: GMP reductase

This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.

Word Map on EC 1.7.1.7

Reaction

IMP
+
NH3
+
NADP+
=
GMP
+
NADPH
+
H+

Synonyms

EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.7 GMP reductase

Source Tissue

Source Tissue on EC 1.7.1.7 - GMP reductase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
strong expression
Manually annotated by BRENDA team
expressed at low levels
Manually annotated by BRENDA team
expressed at low levels
Manually annotated by BRENDA team
expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, is downregulated in invasive stages of human melanoma. From 9 arbitrarily chosen human metastatic melanoma cell lines, GMPR is expressed in only one cell line
Manually annotated by BRENDA team
peripheral
Manually annotated by BRENDA team
additional information
not expressed in testis, lung, liver or spleen
Manually annotated by BRENDA team