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1.7.1.14: nitric oxide reductase [NAD(P)+, nitrous oxide-forming]

This is an abbreviated version!
For detailed information about nitric oxide reductase [NAD(P)+, nitrous oxide-forming], go to the full flat file.

Word Map on EC 1.7.1.14

Reaction

N2O
+
NAD(P)+
+
H2O
= 2 NO +
NAD(P)H
+
H+

Synonyms

Anor, Cnor1, Cnor2, CYP55A1, CYP55A2, CYP55A3, CYP55A4, CYP55A5, CYP55B1, cytochrome P-450nor, cytochrome P450 55B1, cytochrome P450 NADH-NO reductase, cytochrome P450 nitric oxide reductase, cytochrome P450 NO reductase, cytochrome P450nor, Fnor, fungal nitric oxide reductase, NADPH-dependent cytochrome P450nor, NOR, Nor1, Nor1p, P450 nitric oxide reductase, P450nor, P450nor1, P450nor2, P450norA, P450norB, Tnor

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.14 nitric oxide reductase [NAD(P)+, nitrous oxide-forming]

Engineering

Engineering on EC 1.7.1.14 - nitric oxide reductase [NAD(P)+, nitrous oxide-forming]

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G76A
-
the mutation decreases the NADH-dependent activity to 40% of the wild type activity
K77A
-
the mutation decreases the NADH-dependent activity
Q78A
-
the mutation slightly improves the NADH-dependent activity
S73A
-
the mutation decreases the NADH-dependent activity
S73G/S75G
-
the double mutation significantly improves NADPH-dependent Nor activity without affecting, or even slightly increasing, the NADHd-ependent activity
S73G/S75GS75G
-
the mutant exhibits 79% activity of wild type with NADH
S75A
-
the mutation decreases the NADH-dependent activity
T243A
the mutant shows 3% of wild type NO reduction activity
T243N
the mutant shows 2% of wild type NO reduction activity
T243V
the mutant shows 0.01% of wild type NO reduction activity