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1.7.1.1: nitrate reductase (NADH)

This is an abbreviated version!
For detailed information about nitrate reductase (NADH), go to the full flat file.

Word Map on EC 1.7.1.1

Reaction

nitrite
+
NAD+
 +
H2O
=
nitrate
 +
NADH
 +
H+

Synonyms

assimilatory NADH:nitrate reductase, Assimilatory nitrate reductase, cytosolic NADH nitrate reductase, EC 1.6.6.1, EC 1.7.99.4, MSMEG_4206, MSMEI_4108, NADH-dependent nitrate reductase, NADH-Nar, NADH-nitrate reductase, NADH-NO3- reductase, NADH:nitrate oxidoreductase, NaR, NaR1, NasA, NasC, NIA1, Nia2, nitrate reductase, NR, NR1, NR2, Pden_4449, reductase, nitrate

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.1 nitrate reductase (NADH)

Activating Compound

Activating Compound on EC 1.7.1.1 - nitrate reductase (NADH)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethylamine
-
5 mM, 5.6fold stimulation
8-bromo-cyclic GMP
-
addition of 8Br-cGMP, an analogous compound of the secondary messenger cGMP and a secondary signal molecule itself, increases significantly nitrate reductase activity by 51% at 0.01 mM
Calmodulin
-
activates
EDTA
-
reduction of nitrate and menadione requires EDTA
GSH
-
5 mM, 3.8fold stimulation
HPO42-
-
activates
L-Cys
-
5 mM, 5.6fold stimulation
L-cysteic acid
-
5 mM, 2fold stimulation
L-cysteine methyl ester
-
5 mM, 5.6fold stimulation
light
-
enzyme is posttranslationally activated by light. Light also has a positive effect also on de novo synthesis of nitrate reductase. Daily variations in nitrate reductase activity are mainly caused by post-translational modifications. As for angiosperms, the post-translational light activation is inhibited by 3-(3,4-dichlorophenyl)-1,1-dimethylurea, an inhibitor of photosynthesis and stomata opening
-
methylene blue
-
a guanyl cyclase inhibitor, increases significantly the enzymatic activity by 141% at 0.05 mM
phosphate
additional information
-