1.6.5.10: NADPH dehydrogenase (quinone)

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For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.10

1.6.5.10

neutrophil

endothelial

p47phox

phagocyte

apocynin

dismutase

artery

gp91phox

cardiovascular

nicotinamide

hypertension

angiotensin

catalase

oxidases

cardiac

leukocyte

phorbol

monocyte

mapks

sod

aortic

granulomatous

diphenyleneiodonium

diphenylene

pma

iodonium

rac1

atherosclerosis

chemiluminescence

phagocytosis

xanthine

polymorphonuclear

myristate

microglial

myeloperoxidase

ii-induced

dihydroethidium

endothelium-dependent

flavocytochrome

zymosan

peroxynitrite

phagosomes

tempol

fmlp

ros-dependent

microbicidal

nadph-oxidase

nitrotyrosine

lucigenin

medicine

fmlp-induced

Reaction

Synonyms

AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p

ECTree

1 Oxidoreductases

1.6 Acting on NADH or NADPH

1.6.5 With a quinone or similar compound as acceptor

1.6.5.10 NADPH dehydrogenase (quinone)

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Results	in table
4	Activating Compound
139	AA Sequence
2	Application
1	CAS Registry Number
7	Cloned(Commentary)
27	Cofactor
3	Crystallization (Commentary)
6788	Disease/ Diagnostics
3	Expression
10	General Information
1	IC50 Value
32	Inhibitors
6	kcat/KM [mM/s]
3	Ki Value [mM]
39	KM Value [mM]
10	Localization
11	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
33	Organism
10	pH Optimum
33	Protein Variants
8	Purification (Commentary)
2	Reaction
3	Reaction Type
29	Reference
1	Renatured (Commentary)
15	Source Tissue
18	Specific Activity [micromol/min/mg]
104	Substrates and Products (Substrate)
10	Subunits
31	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
32	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.6.5.10 - NADPH dehydrogenase (quinone)

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NADPH:(quinone-acceptor) oxidoreductase

A flavoprotein [1, 2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].