1.6.5.10: NADPH dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.6.5.10
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1.6.5.10
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neutrophil
-
endothelial
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p47phox
-
phagocyte
-
apocynin
-
dismutase
-
artery
-
gp91phox
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cardiovascular
-
nicotinamide
-
hypertension
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angiotensin
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catalase
-
oxidases
-
cardiac
-
leukocyte
-
phorbol
-
monocyte
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mapks
-
sod
-
aortic
-
granulomatous
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diphenyleneiodonium
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diphenylene
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pma
-
iodonium
-
rac1
-
atherosclerosis
-
chemiluminescence
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phagocytosis
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xanthine
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polymorphonuclear
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myristate
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microglial
-
myeloperoxidase
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ii-induced
-
dihydroethidium
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endothelium-dependent
-
flavocytochrome
-
zymosan
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peroxynitrite
-
phagosomes
-
tempol
-
fmlp
-
ros-dependent
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microbicidal
-
nadph-oxidase
-
nitrotyrosine
-
lucigenin
-
medicine
-
fmlp-induced
- 1.6.5.10
- neutrophil
- endothelial
- p47phox
- phagocyte
- apocynin
- dismutase
- artery
- gp91phox
- cardiovascular
- nicotinamide
- hypertension
- angiotensin
- catalase
- oxidases
- cardiac
- leukocyte
-
phorbol
- monocyte
- mapks
- sod
- aortic
- granulomatous
- diphenyleneiodonium
-
diphenylene
- pma
- iodonium
- rac1
- atherosclerosis
-
chemiluminescence
-
phagocytosis
- xanthine
-
polymorphonuclear
- myristate
- microglial
- myeloperoxidase
-
ii-induced
- dihydroethidium
-
endothelium-dependent
-
flavocytochrome
- zymosan
- peroxynitrite
-
phagosomes
-
tempol
- fmlp
-
ros-dependent
-
microbicidal
- nadph-oxidase
-
nitrotyrosine
- lucigenin
- medicine
-
fmlp-induced
Reaction
Synonyms
AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p
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Reference
Reference on EC 1.6.5.10 - NADPH dehydrogenase (quinone)
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Jagendorf, A.T.
Chloroplast TPNH diaphorase
Methods Enzymol.
6
430-434
1963
Spinacia oleracea
-
Koli, A.K.; Yearby, C.; Scott, W.; Donaldson, K.O.
Purification and properties of three separate menadione reductases from hog liver
J. Biol. Chem.
244
621-629
1969
Sus scrofa
Pupillo, P.; de Luca, L.
Pyridine nucleotide-linked dehydrogenases (quinone dependent) in plasma membrane and endoplasmatic reticulum of plant cells
Dev. Plant Biol.
7
321-328
1982
Cucurbita pepo, Zea mays
-
Batot, G.; Martel, C.; Capdeville, N.; Wientjes, F.; Morel, F.
Characterization of neutrophil NADPH oxidase activity reconstituted in a cell-free assay using specific monoclonal antibodies raised against cytochrome b558
Eur. J. Biochem.
234
208-215
1995
Homo sapiens
Diatchuk, V.; Lotan, O.; Koshkin, V.; Wikstroem, P.; Pick, E.
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds
J. Biol. Chem.
272
13292-13301
1997
Cavia porcellus, Homo sapiens
Viljoen, C.C.; Cloete, F.; Scott, W.E.
Isolation and characterization of an NAD(P)H dehydrogenase from the cyanobacterium, Microcystis aeruginosa
Biochim. Biophys. Acta
827
247-259
1985
Microcystis aeruginosa
-
Kim, W.H.; Chung, J.H.; Back, J.H.; Choi, J.; Cha, J.H.; Koh, H.Y.; Han, Y.S.
Molecular cloning and characterization of an NADPH quinone oxidoreductase from Kluyveromyces marxianus
J. Biochem. Mol. Biol.
36
442-449
2003
Kluyveromyces marxianus (Q8NJJ9), Kluyveromyces marxianus
Wang, G.; Maier, R.J.
An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization
Infect. Immun.
72
1391-1396
2004
Helicobacter pylori
Kitzing, K.; Fitzpatrick, T.B.; Wilken, C.; Sawa, J.; Bourenkov, G.P.; Macheroux, P.; Clausen, T.
The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes
J. Biol. Chem.
280
27904-27913
2005
Bacillus subtilis
Gharavi, N.; El-Kadi, A.O.
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide
J. Pharm. Sci.
96
2795-2807
2007
Mus musculus
Hong, Y.; Wang, G.; Maier, R.J.
The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus
Microb. Pathog.
44
169-174
2008
Helicobacter hepaticus, Helicobacter hepaticus ATCC 51449
Huang, S.K.; Chiu, A.W.; Pu, Y.S.; Huang, Y.K.; Chung, C.J.; Tsai, H.J.; Yang, M.H.; Chen, C.J.; Hsueh, Y.M.
Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas
Urol. Int.
80
405-412
2008
Homo sapiens
Wagner, A.E.; Hug, H.; Goessl, R.; Riss, G.; Mussler, B.; Elste, V.; Rimbach, G.; Barella, L.
The natural compound ascorbigen modulates NADPH-quinone oxidoreductase (NQO1) mRNA and enzyme activity levels in cultured liver cells and in laboratory rats
Ann. Nutr. Metab.
53
122-128
2008
Rattus norvegicus
Endo, S.; Matsunaga, T.; Kitade, Y.; Ohno, S.; Tajima, K.; El-Kabbani, O.; Hara, A.
Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase
Biochem. Biophys. Res. Commun.
377
1326-1330
2008
Homo sapiens
Lambertucci, R.H.; Hirabara, S.M.; Silveira, L.d.o.s..R.; Levada-Pires, A.C.; Curi, R.; Pithon-Curi, T.C.
Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells
J. Cell. Physiol.
216
796-804
2008
Rattus norvegicus
Laurindo, F.R.; Fernandes, D.C.; Santos, C.X.
Assessment of superoxide production and NADPH oxidase activity by HPLC analysis of dihydroethidium oxidation products
Methods Enzymol.
441
237-260
2008
Homo sapiens
Zai, C.C.; Tiwari, A.K.; Basile, V.; de Luca, V.; Mueller, D.J.; Voineskos, A.N.; Remington, G.; Meltzer, H.Y.; Lieberman, J.A.; Potkin, S.G.; Kennedy, J.L.
Oxidative stress in tardive dyskinesia: Genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and superoxide dismutase 2 (SOD2, MnSOD) genes
Prog. Neuropsychopharmacol. Biol. Psychiatry
34
50-56
2009
Homo sapiens
Schlegel, B.P.; Ratnam, K.; Penning, T.M.
Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine
Biochemistry
37
11003-11011
1998
Rattus norvegicus (P23457)
Hayashi, M.; Ohzeki, H.; Shimada, H.; Unemoto, T.
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli
Biochim. Biophys. Acta
1273
165-170
1996
Escherichia coli
Crosas, E.; Porte, S.; Moeini, A.; Farres, J.; Biosca, J.A.; Pares, X.; Fernandez, M.R.
Novel alkenal/one reductase activity of yeast NADPH:quinone reductase Zta1p. Prospect of the functional role for the zeta-crystallin family
Chem. Biol. Interact.
191
32-37
2011
Saccharomyces cerevisiae
Hervas, M.; Lopez-Maury, L.; Leon, P.; Sanchez-Riego, A.M.; Florencio, F.J.; Navarro, J.A.
ArsH from the cyanobacterium Synechocystis sp. PCC 6803 is an efficient NADPH-dependent quinone reductase
Biochemistry
51
1178-1187
2012
Synechocystis sp.
Brissos, V.; Goncalves, N.; Melo, E.; Martins, L.
Improving kinetic or thermodynamic stability of an azoreductase by directed evolution
PLoS ONE
9
e87209
2014
Pseudomonas putida, Pseudomonas putida MET94
Flores, E.; Gadda, G.
Kinetic characterization of PA1225 from Pseudomonas aeruginosa PAO1 reveals a new NADPH quinone reductase
Biochemistry
57
3050-3058
2018
Pseudomonas aeruginosa (Q9I4B3), Pseudomonas aeruginosa
Barcarolo, M.; Garavaglia, B.; Gottig, N.; Ceccarelli, E.; Catalano-Dupuy, D.; Ottado, J.
A novel Xanthomonas citri subsp. citri NADPH quinone reductase involved in salt stress response and virulence
Biochim. Biophys. Acta
1864
129514
2020
Xanthomonas citri (Q8PKE6), Xanthomonas citri 306 (Q8PKE6)
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