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1.6.5.10: NADPH dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.10

Reaction

NADPH
+
H+
+
a quinone
=
NADP+
+
a quinol

Synonyms

AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.10 NADPH dehydrogenase (quinone)

Reference

Reference on EC 1.6.5.10 - NADPH dehydrogenase (quinone)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jagendorf, A.T.
Chloroplast TPNH diaphorase
Methods Enzymol.
6
430-434
1963
Spinacia oleracea
-
Manually annotated by BRENDA team
Koli, A.K.; Yearby, C.; Scott, W.; Donaldson, K.O.
Purification and properties of three separate menadione reductases from hog liver
J. Biol. Chem.
244
621-629
1969
Sus scrofa
Manually annotated by BRENDA team
Pupillo, P.; de Luca, L.
Pyridine nucleotide-linked dehydrogenases (quinone dependent) in plasma membrane and endoplasmatic reticulum of plant cells
Dev. Plant Biol.
7
321-328
1982
Cucurbita pepo, Zea mays
-
Manually annotated by BRENDA team
Batot, G.; Martel, C.; Capdeville, N.; Wientjes, F.; Morel, F.
Characterization of neutrophil NADPH oxidase activity reconstituted in a cell-free assay using specific monoclonal antibodies raised against cytochrome b558
Eur. J. Biochem.
234
208-215
1995
Homo sapiens
Manually annotated by BRENDA team
Diatchuk, V.; Lotan, O.; Koshkin, V.; Wikstroem, P.; Pick, E.
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds
J. Biol. Chem.
272
13292-13301
1997
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Viljoen, C.C.; Cloete, F.; Scott, W.E.
Isolation and characterization of an NAD(P)H dehydrogenase from the cyanobacterium, Microcystis aeruginosa
Biochim. Biophys. Acta
827
247-259
1985
Microcystis aeruginosa
-
Manually annotated by BRENDA team
Kim, W.H.; Chung, J.H.; Back, J.H.; Choi, J.; Cha, J.H.; Koh, H.Y.; Han, Y.S.
Molecular cloning and characterization of an NADPH quinone oxidoreductase from Kluyveromyces marxianus
J. Biochem. Mol. Biol.
36
442-449
2003
Kluyveromyces marxianus (Q8NJJ9), Kluyveromyces marxianus
Manually annotated by BRENDA team
Wang, G.; Maier, R.J.
An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization
Infect. Immun.
72
1391-1396
2004
Helicobacter pylori
Manually annotated by BRENDA team
Kitzing, K.; Fitzpatrick, T.B.; Wilken, C.; Sawa, J.; Bourenkov, G.P.; Macheroux, P.; Clausen, T.
The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes
J. Biol. Chem.
280
27904-27913
2005
Bacillus subtilis
Manually annotated by BRENDA team
Gharavi, N.; El-Kadi, A.O.
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide
J. Pharm. Sci.
96
2795-2807
2007
Mus musculus
Manually annotated by BRENDA team
Hong, Y.; Wang, G.; Maier, R.J.
The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus
Microb. Pathog.
44
169-174
2008
Helicobacter hepaticus, Helicobacter hepaticus ATCC 51449
Manually annotated by BRENDA team
Huang, S.K.; Chiu, A.W.; Pu, Y.S.; Huang, Y.K.; Chung, C.J.; Tsai, H.J.; Yang, M.H.; Chen, C.J.; Hsueh, Y.M.
Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas
Urol. Int.
80
405-412
2008
Homo sapiens
Manually annotated by BRENDA team
Wagner, A.E.; Hug, H.; Goessl, R.; Riss, G.; Mussler, B.; Elste, V.; Rimbach, G.; Barella, L.
The natural compound ascorbigen modulates NADPH-quinone oxidoreductase (NQO1) mRNA and enzyme activity levels in cultured liver cells and in laboratory rats
Ann. Nutr. Metab.
53
122-128
2008
Rattus norvegicus
Manually annotated by BRENDA team
Endo, S.; Matsunaga, T.; Kitade, Y.; Ohno, S.; Tajima, K.; El-Kabbani, O.; Hara, A.
Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase
Biochem. Biophys. Res. Commun.
377
1326-1330
2008
Homo sapiens
Manually annotated by BRENDA team
Lambertucci, R.H.; Hirabara, S.M.; Silveira, L.d.o.s..R.; Levada-Pires, A.C.; Curi, R.; Pithon-Curi, T.C.
Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells
J. Cell. Physiol.
216
796-804
2008
Rattus norvegicus
Manually annotated by BRENDA team
Laurindo, F.R.; Fernandes, D.C.; Santos, C.X.
Assessment of superoxide production and NADPH oxidase activity by HPLC analysis of dihydroethidium oxidation products
Methods Enzymol.
441
237-260
2008
Homo sapiens
Manually annotated by BRENDA team
Zai, C.C.; Tiwari, A.K.; Basile, V.; de Luca, V.; Mueller, D.J.; Voineskos, A.N.; Remington, G.; Meltzer, H.Y.; Lieberman, J.A.; Potkin, S.G.; Kennedy, J.L.
Oxidative stress in tardive dyskinesia: Genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and superoxide dismutase 2 (SOD2, MnSOD) genes
Prog. Neuropsychopharmacol. Biol. Psychiatry
34
50-56
2009
Homo sapiens
Manually annotated by BRENDA team
Schlegel, B.P.; Ratnam, K.; Penning, T.M.
Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine
Biochemistry
37
11003-11011
1998
Rattus norvegicus (P23457)
Manually annotated by BRENDA team
Hayashi, M.; Ohzeki, H.; Shimada, H.; Unemoto, T.
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli
Biochim. Biophys. Acta
1273
165-170
1996
Escherichia coli
Manually annotated by BRENDA team
Crosas, E.; Porte, S.; Moeini, A.; Farres, J.; Biosca, J.A.; Pares, X.; Fernandez, M.R.
Novel alkenal/one reductase activity of yeast NADPH:quinone reductase Zta1p. Prospect of the functional role for the zeta-crystallin family
Chem. Biol. Interact.
191
32-37
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hervas, M.; Lopez-Maury, L.; Leon, P.; Sanchez-Riego, A.M.; Florencio, F.J.; Navarro, J.A.
ArsH from the cyanobacterium Synechocystis sp. PCC 6803 is an efficient NADPH-dependent quinone reductase
Biochemistry
51
1178-1187
2012
Synechocystis sp.
Manually annotated by BRENDA team
Brissos, V.; Goncalves, N.; Melo, E.; Martins, L.
Improving kinetic or thermodynamic stability of an azoreductase by directed evolution
PLoS ONE
9
e87209
2014
Pseudomonas putida, Pseudomonas putida MET94
Manually annotated by BRENDA team
Flores, E.; Gadda, G.
Kinetic characterization of PA1225 from Pseudomonas aeruginosa PAO1 reveals a new NADPH quinone reductase
Biochemistry
57
3050-3058
2018
Pseudomonas aeruginosa (Q9I4B3), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Barcarolo, M.; Garavaglia, B.; Gottig, N.; Ceccarelli, E.; Catalano-Dupuy, D.; Ottado, J.
A novel Xanthomonas citri subsp. citri NADPH quinone reductase involved in salt stress response and virulence
Biochim. Biophys. Acta
1864
129514
2020
Xanthomonas citri (Q8PKE6), Xanthomonas citri 306 (Q8PKE6)
Manually annotated by BRENDA team