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1.6.5.10: NADPH dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.10

Reaction

NADPH
+
H+
+
a quinone
=
NADP+
+
a quinol

Synonyms

AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.10 NADPH dehydrogenase (quinone)

Natural Substrates Products

Natural Substrates Products on EC 1.6.5.10 - NADPH dehydrogenase (quinone)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
NADPH + H+ + a quinone
NADP+ + a quinol
show the reaction diagram
-
the catalytic cycle of ArsH consists of the acceptance of two electrons from NADPH to reduce the flavin cofactor (reductive half-reaction) and the transfer of these electrons to an acceptor (oxidative half-reaction)
-
-
?
NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the enzyme plays an important role in managing oxidative stress and contributes to successful colonization of the host
-
-
?