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BRENDA support

1.6.3.5: renalase

This is an abbreviated version!
For detailed information about renalase, go to the full flat file.

Word Map on EC 1.6.3.5

Reaction

1,2-dihydro-beta-NAD(P)
+
H+
+
O2
=
beta-NAD(P)+
+
H2O2

Synonyms

alphaNAD(P)H oxidase/anomerase, REN, Ren-1, Ren-2, Ren1, renalase-1, renalase-2, RnlS

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.5 renalase

Systematic Name

Systematic Name on EC 1.6.3.5 - renalase

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SYSTEMATIC NAME
IUBMB Comments
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.