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BRENDA support

1.6.3.5: renalase

This is an abbreviated version!
For detailed information about renalase, go to the full flat file.

Word Map on EC 1.6.3.5

Reaction

1,2-dihydro-beta-NAD(P)
+
H+
 +
O2
=
beta-NAD(P)+
 +
H2O2

Synonyms

alphaNAD(P)H oxidase/anomerase, REN, Ren-1, Ren-2, Ren1, renalase-1, renalase-2, RnlS

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.5 renalase

Source Tissue

Source Tissue on EC 1.6.3.5 - renalase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
substantial expression in granulosa
Manually annotated by BRENDA team
proximal renal tubular epithelial cell
Manually annotated by BRENDA team
substantial expression in oocytes
Manually annotated by BRENDA team
substantial expression in interstitial and luteal cells of ovary. Expression increases in testes and ovaries as mice develop and is further enhanced in the ovaries of pregnant mice
Manually annotated by BRENDA team
little to no renalase is detected by histochemistry in the normal pancreatic head in the absence of abdominal trauma. In chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples
Manually annotated by BRENDA team
besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine
Manually annotated by BRENDA team
substantial expression spermatogenic cells of testis. Expression increases in testes and ovaries as mice develop
Manually annotated by BRENDA team
additional information
renalase is predominantly expressed in reproductive/steroidogenic systems, with particularly substantial expression in oocytes, granulosa, interstitial and luteal cells of ovary, spermatogenic cells of testis, and cortex of adrenal gland
Manually annotated by BRENDA team