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1.6.3.1: NAD(P)H oxidase (H2O2-forming)

This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O2-forming), go to the full flat file.

Word Map on EC 1.6.3.1

Reaction

NAD(P)H
+
H+
 +
O2
=
NAD(P)+
 +
H2O2

Synonyms

100787949, 100812342, 100820185, Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, cytochrome b-245 heavy chain, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, Glyma.03G236300, Glyma.19G233900, Glyma.20G236200, GLYMA_10G152200, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NM_001184780, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, respiratory burst oxidase homologue, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.1 NAD(P)H oxidase (H2O2-forming)

IC50 Value

IC50 Value on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0049
(-)-epicatechin glucuronide
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.001
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00113
(3Z)-3-(3,4-dihydroxybenzylidene)-5-nitro-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00063
(3Z)-3-[4-hydroxy-3,5-di(propan-2-yl)benzylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00017
2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)phenanthridin-6(5H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00026
2,3,8,9-tetrahydroxy-5-(3-nitrobenzyl)phenanthridin-6(5H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00158
2,3,8,9-tetrahydroxy-5-(4-nitrobenzyl)phenanthridin-6(5H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00158
2,3,8,9-tetrahydroxy-5-[2-(phenylsulfonyl)benzyl]phenanthridin-6(5H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00074
2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-6-methoxy-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00085
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00102
2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00096
2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00059
2-[(2,3,8,9-tetrahydroxy-6-oxophenanthridin-5(6H)-yl)methyl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.00102
2-[(2E)-2-(3,4-dihydroxybenzylidene)hydrazinyl]-N-(3-nitrophenyl)-2-oxoacetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0061
3'-(or 4'-)methylluteolin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0079
3'-O-methyl epicatechin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.00068
3,5,7-trihydroxy-2-(4-hydroxy-3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00079
3-(3,4-dihydroxycyclohexa-2,4-dien-1-yl)-2,7-dihydroxy-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0207
4'-O-methyl epicatechin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.00113
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00134
5-[(2,5-dihydroxybenzyl)amino]-2-hydroxybenzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.03
CERLVRFWRSQQKVV
Homo sapiens
-
pH and temperature not specified in the publication
0.0045
COMT-methylated procyanidin B2
Homo sapiens
-
25°C, pH 7.4, cell lysate
-
0.002
CSTRVRRQLDRNLTFHK
Homo sapiens
-
pH and temperature not specified in the publication
0.0049
dihydrokaempferol
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0041
dihydrotamarixetin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0076
diosmetin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.015
epicatechin gallate
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.008
epigallocatechin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0035
epigallocatechin gallate
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.01
FAVHHDEEDVITG
Homo sapiens
-
pH and temperature not specified in the publication
0.0049
ferulic acid
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.001
FLRGSSACCSTRVRRQL
Homo sapiens
-
pH and temperature not specified in the publication
0.0074
hesperetin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.004
ISNSESGPRGVHFIFNKENF
Homo sapiens
-
pH and temperature not specified in the publication
0.0028
isorhamnetin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0049
isorhamnetin glucuronide
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.02
KTIELQMKKKGFKM
Homo sapiens
-
pH and temperature not specified in the publication
0.025
LKLKKIYFYWLCRDTHAF
Homo sapiens
-
pH and temperature not specified in the publication
0.01
LKSVWYKYCN
Homo sapiens
-
pH and temperature not specified in the publication
0.05
LKSVWYKYCNN
Homo sapiens
-
pH and temperature not specified in the publication
0.00127
methyl 2-hydroxy-5-[(2-hydroxybenzyl)amino]benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.00091
N'1,N'2-bis[(E)-(2,3-dihydroxyphenyl)methylidene]ethanedihydrazide
Homo sapiens
-
pH and temperature not specified in the publication
0.00116
N'1,N'2-bis[(E)-(3,4-dihydroxyphenyl)methylidene]ethanedihydrazide
Homo sapiens
-
pH and temperature not specified in the publication
0.0013
N-(3-aminophenyl)-N'-[1-(4-hydroxy-3-methoxyphenyl)ethyl]ethanediamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0014
N-[(3Z)-3-(4-hydroxy-3-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00164
N-[1-(3,4-dihydroxyphenyl)ethyl]-N'-(3-nitrophenyl)ethanediamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00024
N4-(3-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00107
N4-(4-aminophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0079
naringenin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.0038
procyanidin B2
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.00083
quercetin 3-O-alpha-D-glucopyranoside
Homo sapiens
-
pH and temperature not specified in the publication
0.0049
quercetin glucuronide
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.004
RGVHFIF
Homo sapiens
-
pH and temperature not specified in the publication
0.04
STRVRRQLDRNLTF
Homo sapiens
-
pH and temperature not specified in the publication
0.0074
tamarixetin
Homo sapiens
-
25°C, pH 7.4, cell lysate
0.034
VWYYRVYDIPPKFFYTRKLL
Homo sapiens
-
pH and temperature not specified in the publication