1.6.2.4: NADPH-hemoprotein reductase

This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.

Reaction

Synonyms

107366505, aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, NCP1, neotetrazolin reductase, NPR, NP_000932, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.2 With a heme protein as acceptor

                1.6.2.4 NADPH-hemoprotein reductase

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Results	in table
28	Activating Compound
7952	AA Sequence
11	Application
1	CAS Registry Number
75	Cloned(Commentary)
457	Cofactor
11	Crystallization (Commentary)
1042	Disease/ Diagnostics
16	Expression
46	General Information
8	General Stability
21	IC50 Value
90	Inhibitors
61	kcat/KM [mM/s]
46	Ki Value [mM]
246	KM Value [mM]
234	Localization
11	Metals/Ions
76	Molecular Weight [Da]
152	Natural Substrates/ Products (Substrates)
2633	Organism
249	PDB ID
25	pH Optimum
3	pH Range
8	pI Value
1	Posttranslational Modification
138	Protein Variants
99	Purification (Commentary)
5	Reaction
3	Reaction Type
336	Reference
10	Renatured (Commentary)
337	Source Tissue
190	Specific Activity [micromol/min/mg]
22	Storage Stability
506	Substrates and Products (Substrate)
78	Subunits
412	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
125	Turnover Number [1/s]

KI Value

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KI Value on EC 1.6.2.4 - NADPH-hemoprotein reductase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00026 - 0.0054

2',5'-ADP

12 entries

0.0711 - 0.18

2'-AMP

3 entries

0.0016

Ag+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.0089

AlCl3

Chelon saliens

-

-

687480

0.0728 - 0.073

Cd2+

2 entries

0.0178 - 0.018

Cr3+

2 entries

0.27979

Cu2+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.000048 - 0.00136

Hg2+

3 entries

0.0269

NAD+

Artemisia annua

-

at pH 7.5 and 25°C

742485

0.0003 - 0.0459

NADP+

17 entries

0.329

Ni2+

2 entries

0.0056

TlCl3

Chelon saliens

-

-

687480

0.00026

2',5'-ADP

Artemisia annua

-

at pH 7.5 and 25°C

742485

0.00037

2',5'-ADP

Homo sapiens

P16435

mutant enzyme D634N, at pH 7.5 and 25°C

741783

0.00041

2',5'-ADP

Homo sapiens

P16435

mutant enzyme D634A, at pH 7.5 and 25°C

741783

0.00043

2',5'-ADP

Homo sapiens

P16435

mutant enzyme A635G, at pH 7.5 and 25°C

741783

0.00043

2',5'-ADP

Homo sapiens

P16435

mutant enzyme R636S, at pH 7.5 and 25°C

741783

0.00056

2',5'-ADP

Homo sapiens

-

at pH 7.5 and 25°C

741778

0.00056

2',5'-ADP

Arabidopsis thaliana

-

at pH 7.5 and 25°C

741778

0.0006

2',5'-ADP

Homo sapiens

P16435

wild type enzyme, at pH 7.5 and 25°C

741783

0.00091

2',5'-ADP

Artemisia annua

-

at pH 7.5 and 25°C

741778

0.00131

2',5'-ADP

Homo sapiens

P16435

mutant enzyme R636A, at pH 7.5 and 25°C

741783

0.0045

2',5'-ADP

Homo sapiens

P16435

mutant enzyme A635G/R636S, at pH 7.5 and 25°C

741783

0.0054

2',5'-ADP

Homo sapiens

-

pH 7.0, 25°C

658621

0.0711

2'-AMP

Anopheles minimus

-

pH 7.7, 25°C, NADPH-cytochrome c oxidoreductase lacking the first 55 amino acid residues (DELTA55AnCY)

684727

0.1319

2'-AMP

Anopheles minimus

-

pH 7.7, 25°C, triple mutant L86F/L219F/P456A of NADPH-cytochrome c oxidoreductase lacking the first 55 amino acid residues (DELTA55AnCY)

684727

0.18

2'-AMP

Homo sapiens

-

pH 7.0, 25°C

658621

0.0728

Cd2+

Chelon saliens

-

pH 7.7, 24°C

677198

0.073

Cd2+

Chelon saliens

-

-

677198

0.0178

Cr3+

Chelon saliens

-

pH 7.7, 24°C

677198

0.018

Cr3+

Chelon saliens

-

-

677198

0.000048

Hg2+

Chelon saliens

-

-

677198

0.000048

Hg2+

Chelon saliens

-

pH 7.7, 24°C

677198

0.00136

Hg2+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.0003

NADP+

Homo sapiens

-

mutant enzyme H322A, at pH 7.5 and 25°C

741764

0.00065

NADP+

Homo sapiens

-

mutant enzyme H322Q, at pH 7.5 and 25°C

741764

0.00066

NADP+

Homo sapiens

P16435

mutant enzyme D634N, at pH 7.5 and 25°C

741783

0.00071

NADP+

Homo sapiens

-

at pH 7.5 and 25°C

741778

0.00072

NADP+

Homo sapiens

P16435

mutant enzyme R636S, at pH 7.5 and 25°C

741783

0.00074

NADP+

Homo sapiens

P16435

mutant enzyme D634A, at pH 7.5 and 25°C

741783

0.00095

NADP+

Homo sapiens

-

wild type enzyme, at pH 7.5 and 25°C

741764

0.001

NADP+

Homo sapiens

P16435

wild type enzyme, at pH 7.5 and 25°C

741783

0.001

NADP+

Homo sapiens

P16435

mutant enzyme A635G, at pH 7.5 and 25°C

741783

0.00102

NADP+

Arabidopsis thaliana

-

at pH 7.5 and 25°C

741778

0.00159

NADP+

Artemisia annua

-

at pH 7.5 and 25°C

742485

0.00174

NADP+

Homo sapiens

P16435

mutant enzyme R636A, at pH 7.5 and 25°C

741783

0.0027

NADP+

Homo sapiens

P16435

mutant enzyme A635G/R636S, at pH 7.5 and 25°C

741783

0.0086

NADP+

Artemisia annua

-

at pH 7.5 and 25°C

741778

0.0115

NADP+

Anopheles minimus

-

wild type enzyme, pH not specified in the publication, at 25°C

711027

0.0322

NADP+

Anopheles minimus

-

pH 7.7, 25°C, NADPH-cytochrome c oxidoreductase lacking the first 55 amino acid residues (DELTA55AnCY)

684727

0.0459

NADP+

Anopheles minimus

-

pH 7.7, 25°C, triple mutant L86F/L219F/P456A of NADPH-cytochrome c oxidoreductase lacking the first 55 amino acid residues (DELTA55AnCY)

684727

0.329

Ni2+

Chelon saliens

-

-

677198

0.329

Ni2+

Chelon saliens

-

pH 7.7, 24°C

677198