1.6.2.4: NADPH-hemoprotein reductase

This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.

Reaction

Synonyms

107366505, aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, NCP1, neotetrazolin reductase, NPR, NP_000932, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.2 With a heme protein as acceptor

                1.6.2.4 NADPH-hemoprotein reductase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
28	Activating Compound
7952	AA Sequence
11	Application
1	CAS Registry Number
75	Cloned(Commentary)
457	Cofactor
11	Crystallization (Commentary)
1042	Disease/ Diagnostics
16	Expression
46	General Information
8	General Stability
21	IC50 Value
90	Inhibitors
61	kcat/KM [mM/s]
46	Ki Value [mM]
246	KM Value [mM]
234	Localization
11	Metals/Ions
76	Molecular Weight [Da]
152	Natural Substrates/ Products (Substrates)
2633	Organism
249	PDB ID
25	pH Optimum
3	pH Range
8	pI Value
1	Posttranslational Modification
138	Protein Variants
99	Purification (Commentary)
5	Reaction
3	Reaction Type
336	Reference
10	Renatured (Commentary)
337	Source Tissue
190	Specific Activity [micromol/min/mg]
22	Storage Stability
506	Substrates and Products (Substrate)
78	Subunits
412	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
125	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 1.6.2.4 - NADPH-hemoprotein reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.38 - 8.6

2-chloroethyl ethyl sulfide

5 entries

0.0029877

Ag+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.034

AlCl3

Chelon saliens

-

-

687480

0.14

alpha-lipoic acid

Homo sapiens

-

-

697592

0.024 - 0.033

Cd2+

2 entries

0.024 - 0.033

Cr3+

2 entries

0.39766

Cu2+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.00007 - 0.0021936

Hg2+

3 entries

0.143

Ni2+

2 entries

0.0118 - 0.0174

Tannic acid

2 entries

0.003

TlCl3

Chelon saliens

-

-

687480

0.38

2-chloroethyl ethyl sulfide

Homo sapiens

-

using ferricytochrome c as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C

713542

1.9

2-chloroethyl ethyl sulfide

Mus musculus

-

using ferricytochrome c as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C

713542

2.9

2-chloroethyl ethyl sulfide

Rattus norvegicus

-

in 10 mM phosphate buffer (pH 7.4), at 37°C

713542

3.3

2-chloroethyl ethyl sulfide

Mus musculus

-

using oxidized 2,6-dichlorophenolindophenol as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C

713542

8.6

2-chloroethyl ethyl sulfide

Homo sapiens

-

using oxidized 2,6-dichlorophenolindophenol as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C

713542

0.024

Cd2+

Chelon saliens

-

0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition

677198

0.033

Cd2+

Chelon saliens

-

pH 7.7, 24°C

677198

0.024

Cr3+

Chelon saliens

-

pH 7.7, 24°C

677198

0.033

Cr3+

Chelon saliens

-

0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition

677198

0.00007

Hg2+

Chelon saliens

-

0.05 mM, complete inhibition. IC50: 0.00007 mM, noncompetitive inhibition

677198

0.00007

Hg2+

Chelon saliens

-

pH 7.7, 24°C

677198

0.0021936

Hg2+

Alburnus tarichi

-

at pH 8.0 and 50°C

743879

0.143

Ni2+

Chelon saliens

-

0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition

677198

0.143

Ni2+

Chelon saliens

-

pH 7.7, 24°C

677198

0.0118

Tannic acid

Rattus norvegicus

-

-

686851

0.0174

Tannic acid

Homo sapiens

-

-

686851