1.6.2.2: cytochrome-b5 reductase

This is an abbreviated version!
For detailed information about cytochrome-b5 reductase, go to the full flat file.

Reaction

Synonyms

b5 plus
b5R, b5/b5R, B5R, cb5r, CBR, CBR1, CBR1A, CBR1B, CyB5R, CYB5R2, CYB5R3, Cyb5R4, cyt b5r, cyt b5R protein, cytochrome b5 reductase, cytochrome b5 reductase 2, cytochrome b5 reductase 3, DIA1, diaphorase I, dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase, HPO-19, methemoglobin reductase, NADH cytochrome b5 oxidoreductase, NADH cytochrome B5 reductase, NADH-b5R, NADH-cytochrome b 5 reductase, NADH-cytochrome b5 reductase, NADH-cytochrome b5 reductase 3, NADH-cytochrome-b5 reductase, NADH-cytochrome-b5 reductase 3, NADH-dependent cytochrome b5 reductase, NADH-ferricyanide reductase, NADH-ferricytochrome b5 oxidoreductase, NADH-ferricytochrome reductase, NADH: ferricytochrome b5 oxidoreductase, NADH:cytochrome b5 reductase, NADH:ferricytochrome b5 oxidoreductase, Ncb5or, P34/P32, P35, reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase, reductase, cytochrome b5, T05H4.4

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.2 With a heme protein as acceptor

                1.6.2.2 cytochrome-b5 reductase

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Results	in table
4	Activating Compound
9501	AA Sequence
13	Application
1	CAS Registry Number
37	Cloned(Commentary)
143	Cofactor
13	Crystallization (Commentary)
772	Disease/ Diagnostics
3	Expression
36	General Information
13	General Stability
15	IC50 Value
118	Inhibitors
23	kcat/KM [mM/s]
5	Ki Value [mM]
302	KM Value [mM]
111	Localization
9	Metals/Ions
50	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
170	Organism
1	Oxidation Stability
1	Pathway
21	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
1	pI Value
5	Posttranslational Modification
117	Protein Variants
60	Purification (Commentary)
9	Reaction
3	Reaction Type
167	Reference
1	Renatured (Commentary)
126	Source Tissue
44	Specific Activity [micromol/min/mg]
13	Storage Stability
246	Substrates and Products (Substrate)
41	Subunits
129	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
7	Temperature Stability [°C]
224	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 1.6.2.2 - cytochrome-b5 reductase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

-12

Bos taurus

-

stable

394231

0 - 5

Bos taurus

-

several days

394231

21

Bos taurus

-

several h

394231

40

Physarum polycephalum

Q1HA49

30 min, less than 10% loss of activity

685672

50

Physarum polycephalum

Q1HA49

30 min, 30 min, about 80% loss of activity

685672

51

Physarum polycephalum

-

denaturation temperature. The difference in the hydrophobic interactions in the Physarum polycephalum and human cyt b5R proteins is the primary factor underlying the lower denaturation temperature of Physarum polycephalum cyt b5R

684209

55

Physarum polycephalum

Q1HA49

10 min, complete loss of activity

685672