1.6.1.2: NAD(P)+ transhydrogenase (Re/Si-specific)

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For detailed information about NAD(P)+ transhydrogenase (Re/Si-specific), go to the full flat file.

Word Map on EC 1.6.1.2

1.6.1.2

nadp+

rhodospirillum

rubrum

hydride

transhydrogenation

nadh-binding

submitochondrial

chromatophores

acetylpyridine

dihydronicotinamide

isobutanol

thio-nadp+

acpdad+

Reaction

Synonyms

dII, dIII, energy-linked transhydrogenase, energy-linked, mitochondrial transhydrogenase, H+-thase, mitochondrial transhydrogenase, NAD transhydrogenase, NAD(P) transhydrogenase, NADH transhydrogenase, NADH-NADP-transhydrogenase, NADPH transhydrogenase, NADPH-NAD oxidoreductase, NADPH-NAD transhydrogenase, NADPH:NAD+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, nicotinamide nucleotide transhydrogenase, NNT, PNT, PntAB, proton-translocating nicotinamide nucleotide transhydrogenase, proton-translocating transhydrogenase, pyridine nucleotide transferase, pyridine nucleotide transhydrogenase, reversible mitochondrial membrane-associated transhydrogenase, transhydrogenase, transhydrogenase, nicotinamide adenine dinucleotide (phosphate)

ECTree

1 Oxidoreductases

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific)

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Results	in table
21	Activating Compound
5014	AA Sequence
2	CAS Registry Number
19	Cloned(Commentary)
355	Cofactor
7	Crystallization (Commentary)
4	Disease/ Diagnostics
1	Expression
30	General Information
7	General Stability
123	Inhibitors
30	Ki Value [mM]
33	KM Value [mM]
90	Localization
3	Metals/Ions
28	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
373	Organism
5	Pathway
93	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
1	Posttranslational Modification
37	Protein Variants
28	Purification (Commentary)
15	Reaction
3	Reaction Type
137	Reference
11	Renatured (Commentary)
124	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
137	Substrates and Products (Substrate)
31	Subunits
74	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
9	Temperature Stability [°C]
2	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.6.1.2 - NAD(P)+ transhydrogenase (Re/Si-specific)

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0.044

Escherichia coli

activity in membranes of strain AB1450

392613

0.19

Bos taurus

reduction of acetylpyridine adenine dinucleotide by NADPH

392621

0.26

Klebsiella pneumoniae

activity in inside-out membrane vesicles at pH 7.4, presence of an uncoupler i.e. carbonylcyanide-m-chlorophylhydrazone results in 2fold stimulation

12 - 15

13.6

partially purified enzyme, assay in the presence of Escherichia coli phospholipids

14.2

16.2

2.6

partially purified enzyme

392616

24.6

Bos taurus

reduction of 3-acetylpyridine adenine dinucleotide

392597

35.6

Bos taurus

reduction of 3-acetylpyridine adenine dinucleotide

392611

4.4

Bos taurus

392629, 392637, 392642

50.8

Cereibacter sphaeroides

native enzyme with acetylpyridine-NAD+ a n NADPH as substrates, pH 7.0

62.3

additional information

Cereibacter sphaeroides

no activity detected with the insertion mutants

659015