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1.5.99.12: cytokinin dehydrogenase

This is an abbreviated version!
For detailed information about cytokinin dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.12

Reaction

N6-dimethylallyladenine
+
acceptor
+
H2O
=
adenine
+
3-methylbut-2-enal
+
reduced acceptor

Synonyms

AtCKX2, AtCKX3, AtCKX6, AtCKX7, CKO, CKO1, CKX, CKX1, CKX10, CKX12, CKX2, CKX2-2, CKX3, CKX4, CKX4a, CKX5, CKX6, CKX7, CKX8, CKX9, cytokinin dehydrogenase, cytokinin dehydrogenase 1, cytokinin dehydrogenase CKX1, cytokinin dehydrogenase CKX10, cytokinin oxidase, cytokinin oxidase/dehydrogenase, DhCKX, HvCKX1, isopentenyladenosine oxidase, More, N6-(D2-isopentenyl)adenosine oxidase, N6-dimethylallyladenine dehydrogenase, N6-isopentenylaldenine oxidase, OsCKX2, PsCKX1, PsCKX2, VIT_00s0252g00040, VIT_00s2520g00010, VIT_04s0008g01880, VIT_07s0005g05960, VIT_07s0005g06010, VIT_11s0016g02110, VIT_13s0158g00320, VIT_18s0001g13200, zeatin oxidase, ZmCKO1, ZmCKX1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.12 cytokinin dehydrogenase

Inhibitors

Inhibitors on EC 1.5.99.12 - cytokinin dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2,6-dichloro-pyridin-4-yl)-carbamic acid benzyl ester
-
(2-chloro-pyridin-4-yl)-carbamic acid 4-chloro-phenyl ester
-
1-(2-chloro-1-oxidopyridin-4-yl)-3-phenylurea
-
1-imidazo[1,2-a]pyridin-7-yl-3-phenylurea
-
2,4-Dichlorophenoxyacetic acid
-
inhibits the enzyme by up to 31%
2-amino-6-(3-methoxyanilino)purine
-
-
2-chloro-6-(2-hydroxyanilino)purine
-
-
2-chloro-6-(2-methoxyanilino)purine
-
-
2-chloro-6-(3-chloroanilino)purine
-
-
2-chloro-6-(3-fluoroanilino)purine
-
-
2-chloro-6-(3-hydroxyanilino)purine
-
-
2-chloro-6-(3-methoxyanilino)-9-isopropylpurine
-
-
2-chloro-6-(3-methoxyanilino)-9-methylpurine
-
-
2-chloro-6-(3-methoxyanilino)purine
-
-
2-chloro-6-(4-chloroanilino)purine
-
-
2-chloro-6-(4-fluoroanilino)purine
-
-
2-chloro-6-(4-hydroxyanilino)purine
-
-
2-chloro-6-(4-methoxyanilino)purine
-
-
2-chloro-6-anilinopurine
-
-
2-fluoro-6-(3-methoxyanilino)purine
-
-
2-methylthio-6-(3-methoxyanilino)purine
-
-
2-nitro-6-(3-methoxyanilino)purine
-
-
24-epibrassinolide
-
inhibits both cytokinin oxidase activity and expression. Treatment with 0.4 mM 24-epibrassinolide leads to elevated cytokinin levels in roots and shoots, that are maintained only in the presence of 24-epibrassinolide, while the hormone removal leads to return of cytokinin concentration to the control level initially in the roots and then in the shoots
6-(3-methoxyanilino)purine
-
-
Acriflavine
-
-
adenine
-
slight product inhibition
alpha-naphthaleneacetic acid
-
inhibits the enzyme by up to 54%
cordycepin
-
-
diphenylene iodonium
-
-
diphenylurea
competitive
N-(1,2,3-thidiazol-5-yl)-N'-phenylurea
-
N-(2,6-dichloro-pyridin-4-yl)-N'-benzylurea
-
N-(2,6-dichloro-pyridin-4-yl)-N'-phenoxyurea
-
N-(2,6-dichloro-pyridin-4-yl)-N'-phenylurea
-
N-(2,6-dichloropyridin-4-yl)-N'-benzyl-N'-methylurea
-
N-(2-amino-6-chloro-pyridin-4-yl)-N'-benzylurea
-
N-(2-amino-6-chloro-pyridin-4-yl)-N'-phenylurea
one of the most potent inhibitors of CKO
N-(2-amino-pyridin-4-yl)-N'-phenylurea
one of the most potent inhibitors of CKO
N-(2-chloro-4-pyridyl)-N'-phenylurea
-
-
N-(2-chloro-4-pyridyl-N'-5-fluoro-phenylurea)
-
-
N-(2-chloro-6-methoxy-pyridin-4-yl)-N'-benzylurea
-
N-(2-chloro-pyridin-4-yl)-N'-benzylurea
-
N-(2-chloro-pyridin-4-yl)-N'-phenylurea
the compound binds in a planar conformation and competes for the same binding site with natural substrates
N6-(2-bromo-2-isopentenyl)adenine
weak inhibition
N6-(2-butynyl)adenine
irreversible inhibition
N6-(3-hydroxy-2-phenylethyl)-2-(3-hydroxypropylamino)-9-isopentenyladenine
-
-
N6-(4-hydroxy-2-butynyl)adenine
irreversible inhibition
N6-(buta-2,3-dienyl)adenine
strong irreversible mechanism based inhibition
N6-(penta-2,3-dienyl)adenine
strong irreversible mechanism based inhibition
N6-benzyl-2-(2-hydroxyethylamino)-9-mehtyladenine
-
-
N6-benzyl-2-amino-9-isoproyladenine
-
-
N6-benzyladenine
-
strongly stimulates enzyme activity by up to 180%
N6-but-2,3-dienyl-aminopurine
-
mechanism-based irreversible (suicide) inhibitor. IC50: 0.02 mM with N6-(2-isopentenyl)adenine as substrate, 0.0004 mM with N6-(2-isopentenyl)adenosine as substrate and less than 0.0001 mM with zeatin as substrate
N6-isopentenyl-N-methylaminopurine
structural analogue of isopentenyladenine
N6-pent-2,3-dienyl aminopurine
-
10%, 52%, and 86% inhibition at concentrations of 0.001 mM, 0.01 mM and 0.1 mM
phenylhydrazine
-
-
Quinacrine
-
-
rifampicin
-
-
thidiazuron
trans-zeatin
-
enhances enzyme activity by 35%
additional information
-