1.5.8.3: sarcosine dehydrogenase

This is an abbreviated version!
For detailed information about sarcosine dehydrogenase, go to the full flat file.

Reaction

Synonyms

EC 1.5.99.1, monomethylglycine dehydrogenase, sarcosine N-demethylase, sarcosine:(acceptor) oxidoreductase (demethylating), sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating), SARDH, SDH

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.8 With a flavin or flavoprotein as acceptor

                1.5.8.3 sarcosine dehydrogenase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
187	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
21	Cofactor
77	Disease/ Diagnostics
2	Expression
3	General Information
1	General Stability
11	Inhibitors
2	Ki Value [mM]
16	KM Value [mM]
14	Localization
4	Metals/Ions
10	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
31	Organism
7	Pathway
6	pH Optimum
2	pH Range
3	pH Stability
1	Protein Variants
6	Purification (Commentary)
1	Reaction
4	Reaction Type
31	Reference
31	Source Tissue
4	Specific Activity [micromol/min/mg]
5	Storage Stability
37	Substrates and Products (Substrate)
2	Subunits
11	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 1.5.8.3 - sarcosine dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Homo sapiens

-

reducing the expression of the enzyme promotes localization of TMEFF2 to the cytoskeleton and also results in increased cellular invasion in tumorigenesis

743719

metabolism

Homo sapiens

-

TMEFF2 interacts with SARDH and regulates the cellular levels of sarcosine. The tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine

725421

additional information

Homo sapiens

-

the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells

725421