1.5.8.2: trimethylamine dehydrogenase
This is an abbreviated version!
For detailed information about trimethylamine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.2
-
1.5.8.2
-
flavin
-
flavoproteins
-
fmn
-
iron-sulfur
-
semiquinone
-
mononucleotide
-
methylotrophus
-
methylophilus
-
dimethylamine
-
6-s-cysteinyl
-
isoalloxazine
-
ferricenium
-
flavocytochrome
-
nocardioides
-
flavinylation
-
fmn-binding
-
tetramethylammonium
-
deflavo
-
hyphomicrobium
-
analysis
-
nutrition
- 1.5.8.2
- flavin
- flavoproteins
- fmn
-
iron-sulfur
- semiquinone
- mononucleotide
- methylotrophus
- methylophilus
- dimethylamine
-
6-s-cysteinyl
- isoalloxazine
- ferricenium
-
flavocytochrome
-
nocardioides
-
flavinylation
-
fmn-binding
- tetramethylammonium
-
deflavo
- hyphomicrobium
- analysis
- nutrition
Reaction
Synonyms
EC 1.5.99.7, More, TMA dehydrogenase, TMADH, TMD, TMDH
ECTree
1.5.8.2 trimethylamine dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.5.8.2 - trimethylamine dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
2-chloroethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
40% of the activity compared to trimethylamine
-
?
2-hydroxyethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
70% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
FMN + O2 + H2O
6-hydroxy-FMN + H2O2
-
reaction mechanism, reoxidation of the cofactor, mutant C30A enzyme, low activity with wild-type enzyme and mutant W355L
the hydroxy group oxygen is derived from molecular oxygen not from water
-
r
triethylamine + H2O + phenazine methosulfate
diethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
3% of the activity compared to trimethylamine
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
trimethylamine + H2O + oxidized electron-transferring flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
r
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
trimethylamine + H2O + semiquinone electron-transferring flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
r
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
10% of the activity compared to trimethylamine
-
?
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
10% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
-
-
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
-
-
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
47% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
47% of the activity compared to trimethylamine
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
11% of the activity compared to trimethylamine
-
?
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
11% of the activity compared to trimethylamine
-
?
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
16% of the activity compared to trimethylamine
-
?
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
16% of the activity compared to trimethylamine
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
anaerobic growth conditions
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
anaerobic growth conditions
-
?
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
methylotrophic bacterium
-
electron acceptors: phenazine methosulfate, brilliant cresyl blue, methylene blue
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
reducing equivalents transferred to electron transferring flavoprotein through the 4Fe-4S-center of trimethylamine dehydrogenase, not rate limiting during steady-state turnover
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
a series of conformational changes occur during assembly of the enzyme-electron transferring flavoprotein complex and electron transfer
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
reducing equivalents transferred to electron transferring flavoprotein through the 4Fe-4S-center of trimethylamine dehydrogenase, not rate limiting during steady-state turnover
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
a series of conformational changes occur during assembly of the enzyme-electron transferring flavoprotein complex and electron transfer
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
-
-
-
?
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
-
-
-
?
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
-
-
-
?
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
-
-
-
r
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
reaction mechanism
-
-
r
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
requires the addition of 3 reducing equivalents per subunit for complete reduction
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
requires the addition of 3 reducing equivalents per subunit for complete reduction
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium C2A1
-
-
-
?
additional information
?
-
-
recycling of the prosthetic electron-transferring group FMN by ferricinium, ferrocenedicarboxylic acid, ferrocenemonocarboxylic acid, ferrocenedimathanol, (dimethylamino)methylene ferrocene, and with lower activity by ferricyanide, no electron-transfer activity with 2,6-dichlorophenolindophenol, and thionine
-
-
?
additional information
?
-
-
does not reduce the alphaR237C, alphaR237E, and alphaR237A mutant electron transferring flavoproteins
-
-
?
additional information
?
-
-
does not reduce the alphaR237C, alphaR237E, and alphaR237A mutant electron transferring flavoproteins
-
-
?
additional information
?
-
-
versatile metabolic pathways for the degradation of trimethylamine, phylogenetic analysis of the Paracoccus strains
-
-
?
