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1.5.3.6: (R)-6-hydroxynicotine oxidase

This is an abbreviated version!
For detailed information about (R)-6-hydroxynicotine oxidase, go to the full flat file.

Word Map on EC 1.5.3.6

Reaction

(R)-6-hydroxynicotine
+
H2O
+
O2
=
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one
+
H2O2

Synonyms

6-HDNO, 6-hydroxy-D-nicotine oxidase, D-6-hydroxynicotine oxidase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.6 (R)-6-hydroxynicotine oxidase

Turnover Number

Turnover Number on EC 1.5.3.6 - (R)-6-hydroxynicotine oxidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.5
(R)-4-(1-methylpyrrolidine-2-yl)phenol
Q8GAG1
mutant E352Q, pH 8, 25°C
-
0.85
(R)-6-chloronicotine
Q8GAG1
mutant E350A, pH 8, 25°C
-
0.63 - 77
(R)-6-hydroxynicotine
5.4 - 8.1
(R)-6-hydroxynornicotine
-
0.26
(R)-nicotine
Q8GAG1
mutant E350Q, pH 8, 25°C
19.8
6-hydroxy-D-nicotine
-
30°C pH 9.2