1.5.3.4: N6-methyl-lysine oxidase
This is an abbreviated version!
For detailed information about N6-methyl-lysine oxidase, go to the full flat file.
Reaction
Synonyms
epsilon-alkyl-L-lysine:oxygen oxidoreductase, epsilon-alkyllysinase, epsilon-N-methyllysine demethylase, More, N6-methyllysine oxidase, oxidase, N6-methyllysine
ECTree
1.5.3.4 N6-methyl-lysine oxidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.5.3.4 - N6-methyl-lysine oxidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-(methylamino)-2-oxohexanoic acid + H2O + O2
6-amino-2-oxohexanoic acid + formaldehyde + H2O2
epsilon-N-methyl groups in protein-bound methyllysine residues + O2 + H2O
demethylated lysine residues + formaldehyde + H2O2
N6-ethyl-L-lysine + H2O + O2
L-lysine + acetaldehyde + H2O2
-
about 50% of the activity with N6-methyl-L-lysine
-
-
?
N6-methyl-D-lysine + H2O + O2
D-lysine + formaldehyde + H2O2
-
11% of the activity with epsilon-N-methyl-L-lysine
-
-
?
N6-methyl-L-lysyl-histone + O2 + H2O
histone + formaldehyde + H2O2
-
-
-
-
?
6-(methylamino)-2-oxohexanoic acid + H2O + O2
6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
-
-
-
?
6-(methylamino)-2-oxohexanoic acid + H2O + O2
6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
15% of the activity with N6-methyl-L-lysine
-
-
?
6-(methylamino)-2-oxohexanoic acid + H2O + O2
6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
free alpha-amino group is not required for susceptibility
-
-
?
epsilon-N-methyl groups in protein-bound methyllysine residues + O2 + H2O
demethylated lysine residues + formaldehyde + H2O2
-
methylation of lysyl residues is catalyzed by S-adenosylmethionine:protein (lysine) N-methyltransferase
-
ir
epsilon-N-methyl groups in protein-bound methyllysine residues + O2 + H2O
demethylated lysine residues + formaldehyde + H2O2
-
protein: e.g. histones
-
ir
N6,N6-dimethyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
-
-
-
?
N6,N6-dimethyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
46% of the activity with N6-methyl-L-lysine, it may be oxidized by a different enzyme
-
-
?
N6,N6-dimethyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
enzyme consumes per molecule N6,N6-dimethyl-L-lysine one molecule of oxygen
-
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
-
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
-
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
-
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
-
-
ir
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
reaction in reverse direction, i.e. methylation of L-lysine, is probably catalyzed by protein methylase III
equimolar amounts of L-lysine and formaldehyde
ir
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
highest enzyme activity
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
enzyme consumes per mol N6-methyl-L-lysine half a mol of oxygen
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
-
enzyme consumes per mol N6-methyl-L-lysine half a mol of oxygen
equimolar amounts of L-lysine and formaldehyde
ir
additional information
?
-
-
demethylation involves an electron transport system: FAD is the physiological electron acceptor, phenazine methosulfate as artificial and more efficient electron acceptor than FAD, final electron acceptor is oxygen or 2,6-dichlorophenolindophenol
-
-
?
additional information
?
-
-
not: several acyl derivatives, alpha-N-methyl-L-lysine
-
-
?
additional information
?
-
-
activity restricted to epsilon-N-alkyllysine derivatives
-
-
?
