1.5.3.16: spermine oxidase

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For detailed information about spermine oxidase, go to the full flat file.

Reaction

Synonyms

AtPAO1, AtPAO4, AtPAO5, EC 1.5.3.11, Fms1 protein, GhPAO, hSMO, MmSMO, mSMO, mSMOalpha, mSMOmu, PAO, PAO1, PAO4, PAO5, PAO6, PAO7, PAOh1, PAOh1/SMO, SelPAO5, SMO, SMO(PAOh1), SMO/PAOh1, SMO5, SMOX, spermine oxidase, Spm oxidase, thermospermine oxidase

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.3 With oxygen as acceptor

                1.5.3.16 spermine oxidase

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Results	in table
2	Activating Compound
59	AA Sequence
9	Application
30	Cloned(Commentary)
21	Cofactor
1	Crystallization (Commentary)
189	Disease/ Diagnostics
14	Expression
37	General Information
66	Inhibitors
22	kcat/KM [mM/s]
29	Ki Value [mM]
70	KM Value [mM]
31	Localization
1	Metals/Ions
11	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
78	Organism
8	Pathway
2	PDB ID
23	pH Optimum
6	pH Range
1	pI Value
1	Posttranslational Modification
13	Protein Variants
17	Purification (Commentary)
1	Reaction
71	Reference
1	Renatured (Commentary)
72	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
149	Substrates and Products (Substrate)
14	Subunits
68	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]
44	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.5.3.16 - spermine oxidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

HIV-1 Tat

Homo sapiens

-

Tat-induced SMO activation, involving the polyamine-sensitive subtype of the NMDA receptor, the activation is completely prevented by the NMDAR antagonist MK-801. Mechanism, overview

725069

-

N1,N11-diethylnorspermine

Homo sapiens

-

polyamine analogue with clinical relevance as an experimental anticancer agent. Treatment of human C-28/I2 chondrocytes rapidly induces spermidine/spermine N1-acetyltransferase and spermine oxidase activities, and down-regulates ornithine decarboxylase. The treatment does not provoke cell death and caspase activation when given alone for 24 h, but causes a caspase-3 and -9 dependent apoptosis in chondrocytes further exposed to cycloheximide. The simultaneous addition of N1,N11-diethylnorspermine and cycloheximide rapidly increases caspase activity in C-28/I2 cells in the absence of spermidine/spermineN1-acetyltransferase and spermine oxidase induction or significant reduction of polyamine levels

712558