1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
This is an abbreviated version!
For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.
Word Map on EC 1.5.1.B5
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1.5.1.B5
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sulfatases
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mucopolysaccharidosis
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formylglycine-generating
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metachromatic
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sulfatase-modifying
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leukodystrophy
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ichthyosis
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formylglycine
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aav-mediated
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x-linked
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co-delivery
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intracerebral
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infantile
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autosomal-recessive
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ataxia
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mpsiiia
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adeno-associated
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posttranslationally
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sulfamidase
- 1.5.1.B5
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sulfatases
-
mucopolysaccharidosis
-
formylglycine-generating
-
metachromatic
-
sulfatase-modifying
-
leukodystrophy
-
ichthyosis
-
formylglycine
-
aav-mediated
-
x-linked
-
co-delivery
-
intracerebral
-
infantile
-
autosomal-recessive
-
ataxia
-
mpsiiia
-
adeno-associated
-
posttranslationally
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sulfamidase
Reaction
Synonyms
DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C
ECTree
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Substrates Products
Substrates Products on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
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REACTION DIAGRAM
trans-4-hydroxy-L-proline + NAD+
?
H3ZMH3; H3ZMH4
activity is 70% compared to the activity with L-proline
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?
trans-4-hydroxy-L-proline + NAD+
DELTA1-pyrroline-4R-hydroxy-2-carboxylate + NADPH + H+
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r
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
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highly preferred substrates, preference of the reaction equilibrium in the direction toward NADH-dependent reduction
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-
r
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
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-
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r
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
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highly preferred substrates, preference of the reaction equilibrium in the direction toward NADH-dependent reduction
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-
r
cis-4-hydroxy-L-proline + NAD+
?
H3ZMH3; H3ZMH4
activity is 85% compared to the activity with L-proline
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-
?
DELTA1-pyrroline-4S-hydroxy-2-carboxylate + NADPH + H+
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r
cis-4-hydroxy-L-proline + NAD+
DELTA1-pyrroline-4S-hydroxy-2-carboxylate + NADPH + H+
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r
L-proline + NAD+
H3ZMH3; H3ZMH4
the enzyme is involved in the trans-3-hydroxy-L-proline metabolism
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-
?
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
H3ZMH3; H3ZMH4
preference of the reaction equilibrium in the direction toward NADH-dependent reduction
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-
r
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
H3ZMH3; H3ZMH4
the enzyme is involved in the trans-3-hydroxy-L-proline metabolism
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-
?
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
H3ZMH3; H3ZMH4
preference of the reaction equilibrium in the direction toward NADH-dependent reduction
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-
r
L-pipecolate + NAD+
1-piperideine-2-carboxylate + NADH + H+
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r
DELTA1-piperideine-2-carboxylate + NADH + H+
H3ZMH3; H3ZMH4
activity is 49% compared to the activity with L-proline
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-
?
L-pipecolate + NAD+
DELTA1-piperideine-2-carboxylate + NADH + H+
H3ZMH3; H3ZMH4
activity is 49% compared to the activity with L-proline
-
-
?
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
H3ZMH3; H3ZMH4
preference of the reaction equilibrium in the direction toward NADH-dependent reduction
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-
r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
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-
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r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
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-
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r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
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-
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r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
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r
?
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H3ZMH3; H3ZMH4
the enzyme also shows alanine dehydrogenase activity (EC 1.4.1.1) and N-methyl-L-alanine dehydrogenase activity (EC 1.4.1.17)
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?
additional information
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the enzyme also shows alanine dehydrogenase activity (EC 1.4.1.1) and N-methyl-L-alanine dehydrogenase activity (EC 1.4.1.17)
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additional information
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trans-4-hydroxy-L-proline, L-2-aminovalerate, and N-methyl-L-alanine. TlLhpI shows NAD+-dependent oxidation of L-proline. The kcat/Km value in the presence of NADP+ is about 50fold lower than that in the presence of NAD+. In addition to L-proline, several L-proline analogues, including cis-4-hydroxy-L-proline (85%), trans-4-hydroxy-L-proline (70%), and L-pipecolate (49%), are active substrates (relative activity to L-proline in parentheses). The enzyme also shows low activity with pyruvate, oxaloacetate, 2-oxobutyrate, 2-oxovalerate, and 4-methyl-2-oxovalerate in the oxidation reaction direction, overview
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?
additional information
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trans-4-hydroxy-L-proline, L-2-aminovalerate, and N-methyl-L-alanine. TlLhpI shows NAD+-dependent oxidation of L-proline. The kcat/Km value in the presence of NADP+ is about 50fold lower than that in the presence of NAD+. In addition to L-proline, several L-proline analogues, including cis-4-hydroxy-L-proline (85%), trans-4-hydroxy-L-proline (70%), and L-pipecolate (49%), are active substrates (relative activity to L-proline in parentheses). The enzyme also shows low activity with pyruvate, oxaloacetate, 2-oxobutyrate, 2-oxovalerate, and 4-methyl-2-oxovalerate in the oxidation reaction direction, overview
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-
?
additional information
?
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H3ZMH3; H3ZMH4
the enzyme also shows alanine dehydrogenase activity (EC 1.4.1.1) and N-methyl-L-alanine dehydrogenase activity (EC 1.4.1.17)
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-
?
additional information
?
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the enzyme also shows alanine dehydrogenase activity (EC 1.4.1.1) and N-methyl-L-alanine dehydrogenase activity (EC 1.4.1.17)
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-
?