1.5.1.46: agroclavine dehydrogenase

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For detailed information about agroclavine dehydrogenase, go to the full flat file.

Reaction

Synonyms

agroclavine synthase, EasG

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.46 agroclavine dehydrogenase

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1	Activating Compound
4	AA Sequence
2	Cloned(Commentary)
5	Cofactor
5	Molecular Weight [Da]
4	Organism
3	Pathway
1	Purification (Commentary)
1	Reaction
3	Reference
8	Substrates and Products (Substrate)
5	Subunits
8	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.5.1.46 - agroclavine dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

agroclavine:NADP+ oxidoreductase

The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.