1.5.1.41: riboflavin reductase [NAD(P)H]
This is an abbreviated version!
For detailed information about riboflavin reductase [NAD(P)H], go to the full flat file.
Word Map on EC 1.5.1.41
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1.5.1.41
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nadph:flavin
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nadph
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fad
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ribonucleotide
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iron
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hydroxyurea
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isoalloxazine
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reductases
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prosthetic
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beneckea
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tyrosyl
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harveyi
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eliasson
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fmnh2
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donor-acceptor
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reichard
- 1.5.1.41
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nadph:flavin
- nadph
- fad
-
ribonucleotide
- iron
- hydroxyurea
- isoalloxazine
-
reductases
-
prosthetic
-
beneckea
-
tyrosyl
- harveyi
-
eliasson
- fmnh2
-
donor-acceptor
-
reichard
Reaction
Synonyms
EC 1.5.1.29, EC 1.6.8.1, flavin reductase, flavin reductase HpaCSt, frd1, Frd181, fre, NAD(P)H-dependent H2O2-forming flavin reductase, NAD(P)H:flavin oxidoreductase
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Substrates Products
Substrates Products on EC 1.5.1.41 - riboflavin reductase [NAD(P)H]
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REACTION DIAGRAM
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interactions for flavin substrates are provided by a hydrophobic isoalloxazine binding site that also contains a serine and a threonine, which form hydrogen bonds to the isoalloxazine of bound riboflavin in a substrate complex
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additional information
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enzyme Fre uses the FMN MsrQ cofactor as a substrate to catalyze the electron transfer from cytosolic NADH to the heme. Formation of a specific complex between MsrQ and Fre could favor this unprecedented mechanism, which most likely involves transfer of the reduced FMN cofactor from the Fre active site to MsrQ. Fre forms a specific complex with wild-type MsrQ and the MsrQ H151A mutant. The H151A mutation has no significant quantitative effects on the MsrQ/Fre interaction. Since the MsrQ H151A mutation specifically induces the loss of the FMN cofactor, these data suggest that the flavin cofactor is not involved in the formation of the MsrQ/Fre complex
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