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1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.34

Reaction

a 5,6,7,8-tetrahydropteridine
+
NAD(P)+
=
a 6,7-dihydropteridine
 +
NAD(P)H
 +
H+

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.34 6,7-dihydropteridine reductase

Substrates Products

Substrates Products on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(6R)-L-erythro-dihydrobiopterin + NADH + H+
?
show the reaction diagram
-
-
-
?
(6R)-tetrahydrobiopterin + NAD(P)+
?
show the reaction diagram
-
-
-
r
(6R,S)-6-hydroxy-methyltetrahydropterin + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
(6R,S)-6-methyl-tetrahydropterin + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
(6R,S)-tetrahydrodictyopterin + NAD(P)+
?
show the reaction diagram
-
-
-
r
(6R,S)-tetrahydrofolic acid + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
(6R,S)-tetrahydroneopterin + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
(6S)-tetrahydrobiopterin + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
show the reaction diagram
2-amino-4-hydroxy-6-methyl-5,6,7,8-tetrahydropteridine + NADH
?
show the reaction diagram
-
-
-
-
?
2-amino-4-hydroxy-6-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6-methyl-tetrahydropteridine + NAD(P)+
show the reaction diagram
-
-
-
?
2-amino-4-hydroxy-7-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-7-methyl-tetrahydropteridine + NAD(P)+
show the reaction diagram
-
-
-
?
5,6,7,8-tetrahydrobiopterin + NAD+
quinonoid dihydrobiopterin + NADH + H+
show the reaction diagram
-
-
-
-
r
5,6,7,8-tetrahydropteridine + NAD(P)+
6,7-dihydropteridine + NAD(P)H
show the reaction diagram
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase
-
-
r
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
show the reaction diagram
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
show the reaction diagram
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
6,7-dimethyl-7,8-dihydropterin + NADH + H+
show the reaction diagram
-
-
-
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
quinonoid 6,7-dimethyl dihydropteridine + NADH + H+
show the reaction diagram
-
-
-
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
show the reaction diagram
-
-
-
-
r
6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
-
NADH is preferred in vitro compared to NADPH
-
-
?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
show the reaction diagram
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
show the reaction diagram
6,7-dimethyl-tetrahydropterin + NAD(P)+
?
show the reaction diagram
low activity
-
-
r
6,7-dimethyldihydropterin + NADH + H+
6,7-dimethyltetrahydropterin + NAD+
show the reaction diagram
-
-
-
?
6-methyl-dihydropterin + NADH + H+
6-methyl-tetrahydropterin + NAD+
show the reaction diagram
-
-
-
-
r
6-methyldihydropterin + NADH + H+
quinoid 6,6-dimethyldihydropterin + NAD+
show the reaction diagram
-
-
-
-
r
a 6,7-dihydropteridine + NAD(P)H + H+
a 5,6,7,8-tetrahydropteridine + NAD(P)+
show the reaction diagram
-
-
-
-
?
a 6,7-dihydropteridine + NADPH + H+
a 5,6,7,8-tetrahydropteridine + NADP+
show the reaction diagram
-
-
-
-
?
dihydrobiopterin + NADH + H+
tetrahydrobiopterin + NAD+
show the reaction diagram
dihydrofolate + NADPH
tetrahydrofolate + NADP+
show the reaction diagram
dihydropteroic acid + NAD(P)H
tetrahydropteroate + NAD(P)+
show the reaction diagram
-
-
-
?
dihydropteroylglutamic acid + NAD(P)H
tetrahydropteroylglutamate + NAD(P)+
show the reaction diagram
-
-
-
?
K3Fe(CN)6 + NAD(P)H
K4Fe(CN)6 + NAD(P)+
show the reaction diagram
-
-
-
?
L-threo-neopterin + NAD+
?
show the reaction diagram
-
-
-
-
r
quinoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
-
-
-
-
r
quinoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin
-
-
?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
show the reaction diagram
quinonoid (6R)-D-threo-dihydrobiopterin + NADH + H+
?
show the reaction diagram
-
-
-
?
quinonoid 6,6-dimethyldihydropterin + NAD(P)H
6,6-dimethyltetrahydropterin + NAD(P)+
show the reaction diagram
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
show the reaction diagram
quinonoid 6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropteridine + NAD+
show the reaction diagram
-
-
-
-
r
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
show the reaction diagram
quinonoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
-
-
-
-
r
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
show the reaction diagram
quinonoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
-
-
-
-
r
quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
show the reaction diagram
quinonoid 7,8-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
show the reaction diagram
-
-
-
-
r
quinonoid 7,8-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
show the reaction diagram
quinonoid dihydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)H
tetrahydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)+
show the reaction diagram
-
approx. one-third of activity with 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropterid
-
?
quinonoid dihydro-L-threo-neopterin + NAD(P)H
tetrahydro-L-threo-neopterin + NAD(P)+
show the reaction diagram
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
5,6,7,8-tetrahydrobiopterin + NAD+
show the reaction diagram
-
-
-
-
r
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
show the reaction diagram
quinonoid dihydromonapterin + NAD(P)H
tetrahydromonapterin + NAD(P)+
show the reaction diagram
-
-
-
?
quinonoid dihydroneopterin + NAD(P)H
tetrahydroneopterin + NAD(P)+
show the reaction diagram
-
-
-
?
quinonoid-6-methyl-7,8-dihydrobiopterin + NADH + H+
6-methyl-7,8-dihydropterin + NAD+
show the reaction diagram
-
-
-
-
r
quinonoiddihydro-6-methylpterin + NADH + H+
?
show the reaction diagram
-
-
-
-
r
additional information
?
-