1.5.1.34: 6,7-dihydropteridine reductase
This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.34
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1.5.1.34
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tetrahydrobiopterin
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hydroxylase
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bh4
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hyperphenylalaninemia
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neurotransmitter
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phenylketonuria
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biopterin
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pterins
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dopamine
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quinonoid
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sepiapterin
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1.6.99.7
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cyclohydrolase
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6-pyruvoyl-tetrahydropterin
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5-hydroxytryptophan
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tetrahydropterin
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dihydrobiopterin
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l-dopa
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ptp
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folinic
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nadh-specific
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homovanillic
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pterin-4a-carbinolamine
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guthrie
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6-pyruvoyl
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dihydropterins
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gtpch
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medicine
- 1.5.1.34
- tetrahydrobiopterin
- hydroxylase
- bh4
- hyperphenylalaninemia
-
neurotransmitter
- phenylketonuria
- biopterin
- pterins
- dopamine
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quinonoid
- sepiapterin
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1.6.99.7
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cyclohydrolase
- 6-pyruvoyl-tetrahydropterin
- 5-hydroxytryptophan
- tetrahydropterin
- dihydrobiopterin
- l-dopa
- ptp
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folinic
-
nadh-specific
-
homovanillic
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pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
- dihydropterins
- gtpch
- medicine
Reaction
Synonyms
7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)
ECTree
1.5.1.34 6,7-dihydropteridine reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.5.1.34 - 6,7-dihydropteridine reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,6,7,8-tetrahydropteridine + NAD(P)+
6,7-dihydropteridine + NAD(P)H
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase
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r
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo
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?
a 6,7-dihydropteridine + NAD(P)H + H+
a 5,6,7,8-tetrahydropteridine + NAD(P)+
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?
dihydrobiopterin + NADH + H+
tetrahydrobiopterin + NAD+
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pH 7.4, 37°C
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?
quinoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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?
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
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r
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
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r
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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may also have an important role in regulation of catecholamine synthesis
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential component of the hepatic phenylalanine hydroxylating system
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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no marked specificity for the pteridine cofactor that occurs naturally in this organism L-threo-neopterin
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential component of catecholamine biosynthetic metabolism
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?
additional information
?
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essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage
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?
additional information
?
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in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested
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?
