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1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.34

Reaction

a 5,6,7,8-tetrahydropteridine
+
NAD(P)+
=
a 6,7-dihydropteridine
 +
NAD(P)H
 +
H+

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.34 6,7-dihydropteridine reductase

KM Value

KM Value on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.036
2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydro-pteridine
-
37°C, pH 7.2
0.036
2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine
-
-
0.34
2-Amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine
-
-
0.0152
2-amino-4-hydroxy-6,7-dimethyldihydropteridine
-
cofactor NADH
0.017 - 0.16
5,6,7,8-tetrahydrobiopterin
0.0063 - 0.0152
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin
0.012 - 0.015
6,7-dimethyl-5,6,7,8-tetrahydropterin
0.821
6,7-dimethyl-7,8-dihydropteridine
-
pH 7.4, 22°C, recombinant enzyme
0.03
6,7-dimethyldihydropterin
-
-
0.035
6-Methyl-dihydropterin
-
-
0.366
6-methyl-quinonoid 7,8-(6H)-dihydropterin
-
-
0.0014 - 0.013
6-methyl-tetrahydropterin
0.03
6-methyldihydropterin
-
-
0.754
cis-6,7-dimethyl-quinonoid 7,8-(6H)-dihydropterin
-
-
0.004
dihydrobiopterin
1.45
L-threo-neopterin
-
-
0.00079 - 2.9
NADH
0.0014 - 0.77
NADPH
0.018
quinonoid 2-amino-4-hydroxy-6,7-dimethyl-7,8-dihydropteridine
-
recombinant enzyme
0.006 - 0.34
quinonoid 2-amino-4-hydroxy-6,7-dimethyldihydropteridine
0.4
Quinonoid 6,6-dimethyldihydropterin
0.008 - 0.46
quinonoid 6,7-dimethyl-7,8-dihydropteridine
-
0.0049 - 0.48
quinonoid 6-methyl-7,8-dihydropterin
0.0008 - 0.0063
quinonoid 7,8-(6H)-dihydrobiopterin
0.01 - 0.669
quinonoid 7,8-(6H)-dihydropterin
0.0014 - 0.013
quinonoid 7,8-dihydro-6-methylpterin
0.00015 - 0.0016
quinonoid 7,8-dihydrobiopterin
0.0009 - 0.144
quinonoid 7,8-dihydropterin
0.028
quinonoid dihydrobiobiopterin
-
K150E mutant enzyme
0.00032 - 1
quinonoid dihydrobiopterin
1.32
Quinonoid dihydromonapterin
-
-
1.05
Quinonoid dihydroneopterin
-
-
1.45
quinonoid L-threo-dihydroneopterin
-
-
0.525
quinonoid-6,7-dimethyl-7,8-dihydropterin
-
-
0.128
quinonoid-6-methyl-7,8-dihydrobiopterin
-
-
0.0009 - 0.252
quinonoid-7,8-dihydrobiopterin
0.0034
quinonoiddihydro-6-methylpterin
-
-
0.0009 - 0.017
tetrahydrobiopterin
additional information
additional information
-