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1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.34

Reaction

a 5,6,7,8-tetrahydropteridine
+
NAD(P)+
=
a 6,7-dihydropteridine
 +
NAD(P)H
 +
H+

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.34 6,7-dihydropteridine reductase

KI Value

KI Value on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0019
(R)-2,10,11-trihydroxyapomorphine
0.0012 - 0.0022
(R)-apomorphine
0.0013 - 0.0022
(R)-N-n-propylaporphine
0.0028
1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
noncompetitive inhibition
0.023
2,4-diamino-7,8-dihydropteroylglutamic acid
-
-
0.0295
2,4-diaminopteroic acid
-
-
0.024
2,4-diaminopteroylglutamic acid
-
-
0.014 - 0.031
3',4'-deoxynorlaudanosoline-carboxylic acid
0.0037
3-(4-hydroxyphenyl)pyruvate
-
-
0.024
6-Hydroxydopamine
-
noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH
0.0049
Adrenochrome
-
-
0.01 - 0.21
aminopterin
0.006 - 0.014
dopamine
0.11 - 0.14
epinephrine
0.0015 - 0.0023
higenamine
0.0045
higenamine-1-carboxylic acid
-
vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine
0.26
L-Dopa
-
-
0.016
L-thyroxine
-
-
0.25
L-tyrosine
-
-
0.067
m-tyramine
-
-
0.025 - 0.26
methotrexate
0.0032
NADP+
0.49
noradrenaline
-
noncompetitive inhibition
0.016 - 0.19
norepinephrine
1
phenylalanine
-
mixed inhibition
1
Phenyllactate
-
mixed inhibition
0.05
phenylpyruvate
-
mixed inhibition
0.01
phenylpyruvic acid
-
uncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine
0.022
quinonoid 2,4-diamino-7,8-dihydropteroylglutamic acid
-
-
0.09
salsolinol
-
-
1.2
serotonin
-
competitive inhibition
0.2
tryptophan
-
mixed inhibition
0.024 - 0.05
tyramine
0.074
[4-hydroxyphenyl]acetic acid
-
-