1.5.1.34: 6,7-dihydropteridine reductase

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For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Reaction

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.34 6,7-dihydropteridine reductase

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Results	in table
1596	AA Sequence
2	Application
2	CAS Registry Number
15	Cloned(Commentary)
89	Cofactor
7	Crystallization (Commentary)
719	Disease/ Diagnostics
1	Expression
12	General Information
5	General Stability
1	IC50 Value
161	Inhibitors
52	Ki Value [mM]
194	KM Value [mM]
4	Localization
48	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
29	PDB ID
13	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
30	Protein Variants
35	Purification (Commentary)
4	Reaction
3	Reaction Type
86	Reference
70	Source Tissue
40	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
29	Subunits
43	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
65	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

silky crystals in the presence or absence of NADH upon a slow increase of ammonium sulfate concentration up to 50-55% at pH 6.5

Bos taurus

-

484971

complexed with NAD+, hanging drop vapor diffusion method, using 17% (w/v) polyethylene glycol 3350 and 100 mM Bis-Tris at pH 6.5

Dictyostelium discoideum

Q86A17

725004

dicDHPR-NAD complex by incubation in 20 mM Tris-HCl, pH 8.0, hanging-drop vapor diffusion (4 microl drops), 18°C (291 K), screening solution (0.1 M bis-tris, pH 6.5, 17% PEG 3350), hexahistidine tag not removed, x-ray diffraction

Dictyostelium discoideum

-

695339

hanging drop vapour diffusion, polyethylene glycol 4500, various concentrations of Tris phosphate buffer, pH 7.8, 8% methanol and 1 mM beta-mercaptoethanol, 2.5 A resolution

Homo sapiens

-

485001

hanging drop vapour diffusion, 2 crystal forms depending on whether inorganic salts or alcohols are used as precipitating agents, crystals diffract to at least 2.3 A

Rattus norvegicus

-

484969

hanging drop vapour diffusion, polyethylene glycol 4500, Tris phosphate, pH 7.8, 10% methanol, 4°C, crystals of binary complexes with NADH of recombinant wild-type, W86I, Y146F, Y146H, Y146F/K150Q and A133S mutant enzymes, 2.1-2.3 A resolution

Rattus norvegicus

-

485005

selenomethionine-substitued enzyme in complex with inhibitor methotrexate or substrate dihydrofolate

Trypanosoma cruzi

-

675692